Prolonged paradoxical effect of aspirin on platelet behaviour and bleeding time in man
A single high dose of aspirin(3.9 g orally) was administered to subjects and the time course of the effects on bleeding time, platelet aggregation and platelet production of thromboxane A 2 was followed over a period of one week. Two hours after treatment the bleeding time remained unchanged althoug...
Gespeichert in:
| Veröffentlicht in: | Thrombosis research 1979, Vol.16 (1), p.69-79 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 79 |
|---|---|
| container_issue | 1 |
| container_start_page | 69 |
| container_title | Thrombosis research |
| container_volume | 16 |
| creator | Amezcua, J.L. O'Grady, J. Salmon, J.A. Moncada, S. |
| description | A single high dose of aspirin(3.9 g orally) was administered to subjects and the time course of the effects on bleeding time, platelet aggregation and platelet production of thromboxane A
2 was followed over a period of one week. Two hours after treatment the bleeding time remained unchanged although marked inhibition of the platelet functions and thromboxane A
2 release were detected. Twenty-four and 72 hours after aspirin the bleeding time was substantially increased, returning to normal levels 1 week after treatment. This suggests that shortly after aspirin treatment the production of prostacyclin and thromboxane A2 were blocked. As the recovery of the endothelial cyclo-oxygenase proceeded faster than that of the platelet enzyme the balance prostacyclin/thromboxane A
2 was changed in favour of prostacyclin 24 and 72 h after the treatment, thus explaining the increased bleeding time and its slow recovery over one week. |
| doi_str_mv | 10.1016/0049-3848(79)90270-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_74800034</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0049384879902706</els_id><sourcerecordid>74800034</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-5211b9e98f4a62320d1e2dab50d7716d3b574208111c1c98db0d26e0abf3ff293</originalsourceid><addsrcrecordid>eNp9kMFO3DAURS1EC9MpfzALrxBdpDw7ThxvKlUjCpVGaheUreXYz4NREqd2BrV_T4YZsWT1FvfcK71DyIrBVwasvgYQqigb0VxJ9UUBl1DUJ2TBGqkKLiQ_JYs35Jx8yvkJgEmmqjPysYJKcLUgD79T7OKwRUdHk4yL_4I1HUXv0U40emryGFIYaBzo2JkJO5xoi4_mOcRdomZwtO0QXRi2dAo90hntzfCZfPCmy3hxvEvy58fN_fqu2Py6_bn-vilsWdVTUXHGWoWq8cLUvOTgGHJn2gqclKx2ZVtJwaFhjFlmVeNacLxGMK0vveeqXJLLw-6Y4t8d5kn3IVvsOjNg3GUtRQMApZhBcQBtijkn9HpMoTfpv2ag9zb1XpXeq9JS6Vebup5rq-P-ru3RvZUO-ub42yHG-cfngElnG3Cws480-9Muhvf3XwDAz4On</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>74800034</pqid></control><display><type>article</type><title>Prolonged paradoxical effect of aspirin on platelet behaviour and bleeding time in man</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Amezcua, J.L. ; O'Grady, J. ; Salmon, J.A. ; Moncada, S.</creator><creatorcontrib>Amezcua, J.L. ; O'Grady, J. ; Salmon, J.A. ; Moncada, S.</creatorcontrib><description>A single high dose of aspirin(3.9 g orally) was administered to subjects and the time course of the effects on bleeding time, platelet aggregation and platelet production of thromboxane A
2 was followed over a period of one week. Two hours after treatment the bleeding time remained unchanged although marked inhibition of the platelet functions and thromboxane A
2 release were detected. Twenty-four and 72 hours after aspirin the bleeding time was substantially increased, returning to normal levels 1 week after treatment. This suggests that shortly after aspirin treatment the production of prostacyclin and thromboxane A2 were blocked. As the recovery of the endothelial cyclo-oxygenase proceeded faster than that of the platelet enzyme the balance prostacyclin/thromboxane A
2 was changed in favour of prostacyclin 24 and 72 h after the treatment, thus explaining the increased bleeding time and its slow recovery over one week.</description><identifier>ISSN: 0049-3848</identifier><identifier>EISSN: 1879-2472</identifier><identifier>DOI: 10.1016/0049-3848(79)90270-6</identifier><identifier>PMID: 505429</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Adult ; Aspirin - pharmacology ; Bleeding Time ; Blood Platelets - drug effects ; Collagen - pharmacology ; Dose-Response Relationship, Drug ; Female ; Humans ; Male ; Partial Thromboplastin Time ; Platelet Aggregation - drug effects ; Salicylates - blood ; Thromboxane A2 - biosynthesis ; Time Factors</subject><ispartof>Thrombosis research, 1979, Vol.16 (1), p.69-79</ispartof><rights>1979</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-5211b9e98f4a62320d1e2dab50d7716d3b574208111c1c98db0d26e0abf3ff293</citedby><cites>FETCH-LOGICAL-c356t-5211b9e98f4a62320d1e2dab50d7716d3b574208111c1c98db0d26e0abf3ff293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0049-3848(79)90270-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,4012,27906,27907,27908,45978</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/505429$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Amezcua, J.L.</creatorcontrib><creatorcontrib>O'Grady, J.</creatorcontrib><creatorcontrib>Salmon, J.A.</creatorcontrib><creatorcontrib>Moncada, S.</creatorcontrib><title>Prolonged paradoxical effect of aspirin on platelet behaviour and bleeding time in man</title><title>Thrombosis research</title><addtitle>Thromb Res</addtitle><description>A single high dose of aspirin(3.9 g orally) was administered to subjects and the time course of the effects on bleeding time, platelet aggregation and platelet production of thromboxane A
2 was followed over a period of one week. Two hours after treatment the bleeding time remained unchanged although marked inhibition of the platelet functions and thromboxane A
2 release were detected. Twenty-four and 72 hours after aspirin the bleeding time was substantially increased, returning to normal levels 1 week after treatment. This suggests that shortly after aspirin treatment the production of prostacyclin and thromboxane A2 were blocked. As the recovery of the endothelial cyclo-oxygenase proceeded faster than that of the platelet enzyme the balance prostacyclin/thromboxane A
2 was changed in favour of prostacyclin 24 and 72 h after the treatment, thus explaining the increased bleeding time and its slow recovery over one week.</description><subject>Adult</subject><subject>Aspirin - pharmacology</subject><subject>Bleeding Time</subject><subject>Blood Platelets - drug effects</subject><subject>Collagen - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Partial Thromboplastin Time</subject><subject>Platelet Aggregation - drug effects</subject><subject>Salicylates - blood</subject><subject>Thromboxane A2 - biosynthesis</subject><subject>Time Factors</subject><issn>0049-3848</issn><issn>1879-2472</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFO3DAURS1EC9MpfzALrxBdpDw7ThxvKlUjCpVGaheUreXYz4NREqd2BrV_T4YZsWT1FvfcK71DyIrBVwasvgYQqigb0VxJ9UUBl1DUJ2TBGqkKLiQ_JYs35Jx8yvkJgEmmqjPysYJKcLUgD79T7OKwRUdHk4yL_4I1HUXv0U40emryGFIYaBzo2JkJO5xoi4_mOcRdomZwtO0QXRi2dAo90hntzfCZfPCmy3hxvEvy58fN_fqu2Py6_bn-vilsWdVTUXHGWoWq8cLUvOTgGHJn2gqclKx2ZVtJwaFhjFlmVeNacLxGMK0vveeqXJLLw-6Y4t8d5kn3IVvsOjNg3GUtRQMApZhBcQBtijkn9HpMoTfpv2ag9zb1XpXeq9JS6Vebup5rq-P-ru3RvZUO-ub42yHG-cfngElnG3Cws480-9Muhvf3XwDAz4On</recordid><startdate>1979</startdate><enddate>1979</enddate><creator>Amezcua, J.L.</creator><creator>O'Grady, J.</creator><creator>Salmon, J.A.</creator><creator>Moncada, S.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1979</creationdate><title>Prolonged paradoxical effect of aspirin on platelet behaviour and bleeding time in man</title><author>Amezcua, J.L. ; O'Grady, J. ; Salmon, J.A. ; Moncada, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-5211b9e98f4a62320d1e2dab50d7716d3b574208111c1c98db0d26e0abf3ff293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Adult</topic><topic>Aspirin - pharmacology</topic><topic>Bleeding Time</topic><topic>Blood Platelets - drug effects</topic><topic>Collagen - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Partial Thromboplastin Time</topic><topic>Platelet Aggregation - drug effects</topic><topic>Salicylates - blood</topic><topic>Thromboxane A2 - biosynthesis</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amezcua, J.L.</creatorcontrib><creatorcontrib>O'Grady, J.</creatorcontrib><creatorcontrib>Salmon, J.A.</creatorcontrib><creatorcontrib>Moncada, S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Thrombosis research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amezcua, J.L.</au><au>O'Grady, J.</au><au>Salmon, J.A.</au><au>Moncada, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prolonged paradoxical effect of aspirin on platelet behaviour and bleeding time in man</atitle><jtitle>Thrombosis research</jtitle><addtitle>Thromb Res</addtitle><date>1979</date><risdate>1979</risdate><volume>16</volume><issue>1</issue><spage>69</spage><epage>79</epage><pages>69-79</pages><issn>0049-3848</issn><eissn>1879-2472</eissn><abstract>A single high dose of aspirin(3.9 g orally) was administered to subjects and the time course of the effects on bleeding time, platelet aggregation and platelet production of thromboxane A
2 was followed over a period of one week. Two hours after treatment the bleeding time remained unchanged although marked inhibition of the platelet functions and thromboxane A
2 release were detected. Twenty-four and 72 hours after aspirin the bleeding time was substantially increased, returning to normal levels 1 week after treatment. This suggests that shortly after aspirin treatment the production of prostacyclin and thromboxane A2 were blocked. As the recovery of the endothelial cyclo-oxygenase proceeded faster than that of the platelet enzyme the balance prostacyclin/thromboxane A
2 was changed in favour of prostacyclin 24 and 72 h after the treatment, thus explaining the increased bleeding time and its slow recovery over one week.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>505429</pmid><doi>10.1016/0049-3848(79)90270-6</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0049-3848 |
| ispartof | Thrombosis research, 1979, Vol.16 (1), p.69-79 |
| issn | 0049-3848 1879-2472 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74800034 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Aspirin - pharmacology Bleeding Time Blood Platelets - drug effects Collagen - pharmacology Dose-Response Relationship, Drug Female Humans Male Partial Thromboplastin Time Platelet Aggregation - drug effects Salicylates - blood Thromboxane A2 - biosynthesis Time Factors |
| title | Prolonged paradoxical effect of aspirin on platelet behaviour and bleeding time in man |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T19%3A44%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prolonged%20paradoxical%20effect%20of%20aspirin%20on%20platelet%20behaviour%20and%20bleeding%20time%20in%20man&rft.jtitle=Thrombosis%20research&rft.au=Amezcua,%20J.L.&rft.date=1979&rft.volume=16&rft.issue=1&rft.spage=69&rft.epage=79&rft.pages=69-79&rft.issn=0049-3848&rft.eissn=1879-2472&rft_id=info:doi/10.1016/0049-3848(79)90270-6&rft_dat=%3Cproquest_cross%3E74800034%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=74800034&rft_id=info:pmid/505429&rft_els_id=0049384879902706&rfr_iscdi=true |