Defective N-oxidation of sparteine in man: a new pharmacogenetic defect

Sparteine, an antiarrhythmic and oxytocic drug, is metabolised by N1-oxidation. The sparteine-N1-oxide rearranges with loss of water to 2- and 5-dehydrosparteine. 18 (i.e., 5%) out of 360 subjects were unable to metabolise the drug. These persons, who were designated as nonmetabolisers, excreted alm...

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Veröffentlicht in:	European journal of clinical pharmacology 1979-01, Vol.16 (3), p.183-187
Hauptverfasser:	Eichelbaum, M, Spannbrucker, N, Steincke, B, Dengler, H J
Format:	Artikel
Sprache:	eng
Schlagworte:	Family Female Humans Male Molecular Biology Oxidation-Reduction Phenotype Sparteine - metabolism Sparteine - urine
Online-Zugang:	Volltext
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