Myocardial lesions produced by digitalis in the presence of hyperthyroidism; an experimental study

Calculated therapeutic doses of digitalis and its derivatives did not produce demonstrable microscopic changes in the myocardium of experimental animals. Toxic doses of digitalis (twice a therapeutic dose) induced myocardial lesions in animals. In those animals with experimentally induced mild to mo...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 1950-03, Vol.1 (3), p.394-403
Hauptverfasser:	DEARING, W H, BARNES, A R, ESSEX, H E
Format:	Artikel
Sprache:	eng
Schlagworte:	Digitalis Digitalis Glycosides Health Services Heart Hyperthyroidism Old Medline Thyroid Gland
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description	Calculated therapeutic doses of digitalis and its derivatives did not produce demonstrable microscopic changes in the myocardium of experimental animals. Toxic doses of digitalis (twice a therapeutic dose) induced myocardial lesions in animals. In those animals with experimentally induced mild to moderate hyperthyroidism, calculated therapeutic doses of digitalis did produce myocardial lesions. Toxic doses of digitalis administered to animals with mild to moderate hyperthyroidism caused extensive degenerative changes in the myocardium or promptly killed the animals without associated microscopic lesions.
doi_str_mv	10.1161/01.CIR.1.3.394
format	Article
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Toxic doses of digitalis (twice a therapeutic dose) induced myocardial lesions in animals. In those animals with experimentally induced mild to moderate hyperthyroidism, calculated therapeutic doses of digitalis did produce myocardial lesions. Toxic doses of digitalis administered to animals with mild to moderate hyperthyroidism caused extensive degenerative changes in the myocardium or promptly killed the animals without associated microscopic lesions.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/01.CIR.1.3.394</identifier><identifier>PMID: 15405707</identifier><language>eng</language><publisher>United States</publisher><subject>Digitalis ; Digitalis Glycosides ; Health Services ; Heart ; Hyperthyroidism ; Old Medline ; Thyroid Gland</subject><ispartof>Circulation (New York, N.Y.), 1950-03, Vol.1 (3), p.394-403</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c302t-839c60b28d840b6c3cfb2c837747ee990ebdc79c9bfb1df03ddfde886e30175a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15405707$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DEARING, W H</creatorcontrib><creatorcontrib>BARNES, A R</creatorcontrib><creatorcontrib>ESSEX, H E</creatorcontrib><title>Myocardial lesions produced by digitalis in the presence of hyperthyroidism; an experimental study</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>Calculated therapeutic doses of digitalis and its derivatives did not produce demonstrable microscopic changes in the myocardium of experimental animals. Toxic doses of digitalis (twice a therapeutic dose) induced myocardial lesions in animals. In those animals with experimentally induced mild to moderate hyperthyroidism, calculated therapeutic doses of digitalis did produce myocardial lesions. Toxic doses of digitalis administered to animals with mild to moderate hyperthyroidism caused extensive degenerative changes in the myocardium or promptly killed the animals without associated microscopic lesions.</description><subject>Digitalis</subject><subject>Digitalis Glycosides</subject><subject>Health Services</subject><subject>Heart</subject><subject>Hyperthyroidism</subject><subject>Old Medline</subject><subject>Thyroid Gland</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1950</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1LxDAQxYMouq5ePUpO3lonTds0eJLFj4UVQfQc8jF1I_1Ymxbsf29kFzwNM_Pe4_Ej5IpByljJboGlq_VbylKecpkfkQUrsjzJCy6PyQIAZCJ4lp2R8xC-4lpyUZySM1bkUAgQC2Je5t7qwXnd0AaD77tAd0PvJouOmpk6_-lH3fhAfUfHLcYnBuws0r6m23mHw7idh947H9o7qjuKP_HmW-yii4ZxcvMFOal1E_DyMJfk4_HhffWcbF6f1qv7TWI5ZGNScWlLMFnlqhxMabmtTWYrLkQuEKUENM4KaaWpDXM1cOdqh1VVIgcmCs2X5GafG_t_TxhG1fpgsWl0h_0UVMwRILM8CtO90A59CAPWahcb62FWDNQfVQVMRaqKKa4i1Wi4PiRPpkX3Lz9g5L_CAXUP</recordid><startdate>195003</startdate><enddate>195003</enddate><creator>DEARING, W H</creator><creator>BARNES, A R</creator><creator>ESSEX, H E</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>195003</creationdate><title>Myocardial lesions produced by digitalis in the presence of hyperthyroidism; an experimental study</title><author>DEARING, W H ; BARNES, A R ; ESSEX, H E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c302t-839c60b28d840b6c3cfb2c837747ee990ebdc79c9bfb1df03ddfde886e30175a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1950</creationdate><topic>Digitalis</topic><topic>Digitalis Glycosides</topic><topic>Health Services</topic><topic>Heart</topic><topic>Hyperthyroidism</topic><topic>Old Medline</topic><topic>Thyroid Gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DEARING, W H</creatorcontrib><creatorcontrib>BARNES, A R</creatorcontrib><creatorcontrib>ESSEX, H E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DEARING, W H</au><au>BARNES, A R</au><au>ESSEX, H E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Myocardial lesions produced by digitalis in the presence of hyperthyroidism; an experimental study</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>1950-03</date><risdate>1950</risdate><volume>1</volume><issue>3</issue><spage>394</spage><epage>403</epage><pages>394-403</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><abstract>Calculated therapeutic doses of digitalis and its derivatives did not produce demonstrable microscopic changes in the myocardium of experimental animals. Toxic doses of digitalis (twice a therapeutic dose) induced myocardial lesions in animals. In those animals with experimentally induced mild to moderate hyperthyroidism, calculated therapeutic doses of digitalis did produce myocardial lesions. Toxic doses of digitalis administered to animals with mild to moderate hyperthyroidism caused extensive degenerative changes in the myocardium or promptly killed the animals without associated microscopic lesions.</abstract><cop>United States</cop><pmid>15405707</pmid><doi>10.1161/01.CIR.1.3.394</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record>
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source	MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete
subjects	Digitalis Digitalis Glycosides Health Services Heart Hyperthyroidism Old Medline Thyroid Gland
title	Myocardial lesions produced by digitalis in the presence of hyperthyroidism; an experimental study
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