Formation of adducts of parthenin and related sesquiterpene lactones with cysteine and glutathione
Parthenin, the major sesquiterpene lactone of Parthenium hysterophorus, a weed responsible for dermatitis in man is primarily restricted to leaf and stem trichomes. Parthenin forms a monoadduct with L-cysteine through the α-methylene group of the γ-lactone and a biadduct with the endocyclic double b...
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| Veröffentlicht in: | Chemico-biological interactions 1979-01, Vol.28 (1), p.83-89 |
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| container_title | Chemico-biological interactions |
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| creator | Picman, Anna K. Rodriguez, Eloy Towers, G.H.N. |
| description | Parthenin, the major sesquiterpene lactone of
Parthenium hysterophorus, a weed responsible for dermatitis in man is primarily restricted to leaf and stem trichomes. Parthenin forms a monoadduct with L-cysteine through the α-methylene group of the γ-lactone and a biadduct with the endocyclic double bond on the cyclopentenone ring. Studies with other sesquiterpene lactones support the view that the types of adducts formed are correlated with the biological activity of the sesquiterpene lactones. |
| doi_str_mv | 10.1016/0009-2797(79)90116-9 |
| format | Article |
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Parthenium hysterophorus, a weed responsible for dermatitis in man is primarily restricted to leaf and stem trichomes. Parthenin forms a monoadduct with L-cysteine through the α-methylene group of the γ-lactone and a biadduct with the endocyclic double bond on the cyclopentenone ring. Studies with other sesquiterpene lactones support the view that the types of adducts formed are correlated with the biological activity of the sesquiterpene lactones.</description><identifier>ISSN: 0009-2797</identifier><identifier>EISSN: 1872-7786</identifier><identifier>DOI: 10.1016/0009-2797(79)90116-9</identifier><identifier>PMID: 498366</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Allergens ; Chemical Phenomena ; Chemistry ; Cysteine ; Glutathione ; Lactones ; Parthenium hysterophorus ; Sesquiterpenes ; weeds</subject><ispartof>Chemico-biological interactions, 1979-01, Vol.28 (1), p.83-89</ispartof><rights>1979</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c380t-e879ce7e565b7a45a5d05a1601dedb8868ab64a81b093ab2050c7c162a00c0583</citedby><cites>FETCH-LOGICAL-c380t-e879ce7e565b7a45a5d05a1601dedb8868ab64a81b093ab2050c7c162a00c0583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0009279779901169$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/498366$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Picman, Anna K.</creatorcontrib><creatorcontrib>Rodriguez, Eloy</creatorcontrib><creatorcontrib>Towers, G.H.N.</creatorcontrib><title>Formation of adducts of parthenin and related sesquiterpene lactones with cysteine and glutathione</title><title>Chemico-biological interactions</title><addtitle>Chem Biol Interact</addtitle><description>Parthenin, the major sesquiterpene lactone of
Parthenium hysterophorus, a weed responsible for dermatitis in man is primarily restricted to leaf and stem trichomes. Parthenin forms a monoadduct with L-cysteine through the α-methylene group of the γ-lactone and a biadduct with the endocyclic double bond on the cyclopentenone ring. Studies with other sesquiterpene lactones support the view that the types of adducts formed are correlated with the biological activity of the sesquiterpene lactones.</description><subject>Allergens</subject><subject>Chemical Phenomena</subject><subject>Chemistry</subject><subject>Cysteine</subject><subject>Glutathione</subject><subject>Lactones</subject><subject>Parthenium hysterophorus</subject><subject>Sesquiterpenes</subject><subject>weeds</subject><issn>0009-2797</issn><issn>1872-7786</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1LHTEQhkOp1aPtPxDcK6kXWyf7kY-bQpHaCoIX1eswm8zxRPZsjknWcv69u13xsjCQmcz7vgwPY6ccvnHg4hIAdFlJLb9KfaGBc1HqD2zFlaxKKZX4yFbvkiN2nNLTNELVwCH71GhVC7Fi3XWIW8w-DEVYF-jcaHOa2x3GvKHBDwUOrojUYyZXJErPo88UdzRQ0aPNYaBU_PV5U9h9yuSn79nw2I8Z82bKpc_sYI19oi9v7wl7uP55f_W7vL37dXP147a0tYJckpLakqRWtJ3EpsXWQYtcAHfkOqWEwk40qHgHusaughastFxUCGChVfUJO19ydzE8j5Sy2fpkqe9xoDAmIxsphG7rSdgsQhtDSpHWZhf9FuPecDAzWTNjMzM2I7X5R9boyXb6lj92W3LvpgXltD5b1msMBh-jT-bhTwW8nqpWSs8Hfl8UNFF48RRNsp4GS85Hstm44P9_wSsPjZJL</recordid><startdate>19790101</startdate><enddate>19790101</enddate><creator>Picman, Anna K.</creator><creator>Rodriguez, Eloy</creator><creator>Towers, G.H.N.</creator><general>Elsevier Ireland Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19790101</creationdate><title>Formation of adducts of parthenin and related sesquiterpene lactones with cysteine and glutathione</title><author>Picman, Anna K. ; Rodriguez, Eloy ; Towers, G.H.N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-e879ce7e565b7a45a5d05a1601dedb8868ab64a81b093ab2050c7c162a00c0583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Allergens</topic><topic>Chemical Phenomena</topic><topic>Chemistry</topic><topic>Cysteine</topic><topic>Glutathione</topic><topic>Lactones</topic><topic>Parthenium hysterophorus</topic><topic>Sesquiterpenes</topic><topic>weeds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Picman, Anna K.</creatorcontrib><creatorcontrib>Rodriguez, Eloy</creatorcontrib><creatorcontrib>Towers, G.H.N.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chemico-biological interactions</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Picman, Anna K.</au><au>Rodriguez, Eloy</au><au>Towers, G.H.N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Formation of adducts of parthenin and related sesquiterpene lactones with cysteine and glutathione</atitle><jtitle>Chemico-biological interactions</jtitle><addtitle>Chem Biol Interact</addtitle><date>1979-01-01</date><risdate>1979</risdate><volume>28</volume><issue>1</issue><spage>83</spage><epage>89</epage><pages>83-89</pages><issn>0009-2797</issn><eissn>1872-7786</eissn><abstract>Parthenin, the major sesquiterpene lactone of
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| issn | 0009-2797 1872-7786 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Allergens Chemical Phenomena Chemistry Cysteine Glutathione Lactones Parthenium hysterophorus Sesquiterpenes weeds |
| title | Formation of adducts of parthenin and related sesquiterpene lactones with cysteine and glutathione |
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