Pharmacokinetics of cefaclor in patients with stable renal impairment, and patients undergoing haemodialysis
The pharmacokinetics of cefaclor, a new orally absorbable cephalosporin antibiotic, were studied in five patients with mild to moderate renal impairment and in six patients with severe renal insufficiency undergoing chronic haemodialysis. Peak serum levels of cefaclor in both groups were comparable...
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| Veröffentlicht in: | Journal of antimicrobial chemotherapy 1979-07, Vol.5 (4), p.465-470 |
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| container_end_page | 470 |
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| container_issue | 4 |
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| container_title | Journal of antimicrobial chemotherapy |
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| creator | Gartenberg, Gary Meyers, Burt R. Hirschman, Shalom Z. Srulevitch, Elina |
| description | The pharmacokinetics of cefaclor, a new orally absorbable cephalosporin antibiotic, were studied in five patients with mild to moderate renal impairment and in six patients with severe renal insufficiency undergoing chronic haemodialysis. Peak serum levels of cefaclor in both groups were comparable to those reported in patients with normal renal function. In patients with mild to moderate renal dysfunction, the serum half life (T½) ranged from 1.41 to 2.68 h. During haemodialysis the T½ was 1.99 to 2.14 h. Haemodialysis was effective in clearing cefaclor with clearances of 13.5 to 54.2 ml/min. Urine concentrations of cefaclor in patients with mild to moderate renal impairment were high enough to inhibit most common urinary pathogens. |
| doi_str_mv | 10.1093/jac/5.4.465 |
| format | Article |
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Peak serum levels of cefaclor in both groups were comparable to those reported in patients with normal renal function. In patients with mild to moderate renal dysfunction, the serum half life (T½) ranged from 1.41 to 2.68 h. During haemodialysis the T½ was 1.99 to 2.14 h. Haemodialysis was effective in clearing cefaclor with clearances of 13.5 to 54.2 ml/min. 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Peak serum levels of cefaclor in both groups were comparable to those reported in patients with normal renal function. In patients with mild to moderate renal dysfunction, the serum half life (T½) ranged from 1.41 to 2.68 h. During haemodialysis the T½ was 1.99 to 2.14 h. Haemodialysis was effective in clearing cefaclor with clearances of 13.5 to 54.2 ml/min. Urine concentrations of cefaclor in patients with mild to moderate renal impairment were high enough to inhibit most common urinary pathogens.</description><subject>Adult</subject><subject>Aged</subject><subject>Cefaclor - blood</subject><subject>Cefaclor - metabolism</subject><subject>Cefaclor - urine</subject><subject>Cephalexin - analogs & derivatives</subject><subject>Female</subject><subject>Humans</subject><subject>Kidney Diseases - metabolism</subject><subject>Kidney Diseases - therapy</subject><subject>Kidney Failure, Chronic - metabolism</subject><subject>Kinetics</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Renal Dialysis</subject><subject>Time Factors</subject><issn>0305-7453</issn><issn>1460-2091</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtPGzEURi0ElPBYse3Cq27aCfb4MTPLCrVNRSQiVCTExrpjXydO5hHsiSj_voOC0tVdnKNPuoeQa86mnFXiZg32Rk3lVGp1RCZcapblrOLHZMIEU1khlTgj5ymtGWNa6fITOZVlJSs5Ic1iBbEF229Ch0OwifaeWvRgmz7S0NEtDAG7IdHXMKxoGqBukEbsoKGh3UKI7Ui_Uejcf3XXOYzLPnRLugJsexegeUshXZITD03Cq497QR5__vhzO8vm979-336fZzYXesi09IhgoXI1eGBlOT6pvFOV4xKlyOvSecFKXUngecHzHLzjrqwdgq8dCHFBvux3t7F_2WEaTBuSxaaBDvtdMoUstMzVu_h1L9rYpxTRm20MLcQ3w5l5T2vGtEYZaca0o_35Y3ZXt-gO7r7liLM9DmnAvwcKcWN0IQplZk_PZqbu8mrxsDBz8Q896ocd</recordid><startdate>197907</startdate><enddate>197907</enddate><creator>Gartenberg, Gary</creator><creator>Meyers, Burt R.</creator><creator>Hirschman, Shalom Z.</creator><creator>Srulevitch, Elina</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197907</creationdate><title>Pharmacokinetics of cefaclor in patients with stable renal impairment, and patients undergoing haemodialysis</title><author>Gartenberg, Gary ; Meyers, Burt R. ; Hirschman, Shalom Z. ; Srulevitch, Elina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c236t-64feeaca9dbafa0881095fd59d14e432b8df308694a127122afd1d8bdeafbda33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Cefaclor - blood</topic><topic>Cefaclor - metabolism</topic><topic>Cefaclor - urine</topic><topic>Cephalexin - analogs & derivatives</topic><topic>Female</topic><topic>Humans</topic><topic>Kidney Diseases - metabolism</topic><topic>Kidney Diseases - therapy</topic><topic>Kidney Failure, Chronic - metabolism</topic><topic>Kinetics</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Renal Dialysis</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gartenberg, Gary</creatorcontrib><creatorcontrib>Meyers, Burt R.</creatorcontrib><creatorcontrib>Hirschman, Shalom Z.</creatorcontrib><creatorcontrib>Srulevitch, Elina</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antimicrobial chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gartenberg, Gary</au><au>Meyers, Burt R.</au><au>Hirschman, Shalom Z.</au><au>Srulevitch, Elina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmacokinetics of cefaclor in patients with stable renal impairment, and patients undergoing haemodialysis</atitle><jtitle>Journal of antimicrobial chemotherapy</jtitle><addtitle>J Antimicrob Chemother</addtitle><date>1979-07</date><risdate>1979</risdate><volume>5</volume><issue>4</issue><spage>465</spage><epage>470</epage><pages>465-470</pages><issn>0305-7453</issn><eissn>1460-2091</eissn><abstract>The pharmacokinetics of cefaclor, a new orally absorbable cephalosporin antibiotic, were studied in five patients with mild to moderate renal impairment and in six patients with severe renal insufficiency undergoing chronic haemodialysis. 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| fulltext | fulltext |
| identifier | ISSN: 0305-7453 |
| ispartof | Journal of antimicrobial chemotherapy, 1979-07, Vol.5 (4), p.465-470 |
| issn | 0305-7453 1460-2091 |
| language | eng |
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| source | Oxford University Press Journals Digital Archive legacy; MEDLINE |
| subjects | Adult Aged Cefaclor - blood Cefaclor - metabolism Cefaclor - urine Cephalexin - analogs & derivatives Female Humans Kidney Diseases - metabolism Kidney Diseases - therapy Kidney Failure, Chronic - metabolism Kinetics Male Middle Aged Renal Dialysis Time Factors |
| title | Pharmacokinetics of cefaclor in patients with stable renal impairment, and patients undergoing haemodialysis |
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