Use of combined plasmapheresis and immunosuppression in the treatment of Goodpasture's syndrome
Five consecutive patients with well-documented Goodpasture's syndrome were treated with plasmapheresis and immunosuppression. In all patients, the antiglomerular basement-membrane antibody titers decreased with treatment. In three patients, hemoptysis responded promptly to plasmapheresis. Two p...
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| Veröffentlicht in: | Mayo Clinic proceedings 1979-11, Vol.54 (11), p.714-720 |
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| container_title | Mayo Clinic proceedings |
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| creator | Erickson, S B Kurtz, S B Donadio, Jr, J V Holley, K E Wilson, C B Pineda, A A |
| description | Five consecutive patients with well-documented Goodpasture's syndrome were treated with plasmapheresis and immunosuppression. In all patients, the antiglomerular basement-membrane antibody titers decreased with treatment. In three patients, hemoptysis responded promptly to plasmapheresis. Two patients presenting with severe renal failure required chronic dialysis, and three patients who had serum creatinine levels less than 2.1 mg/dl before treatment improved or had stabilization of their renal function. We confirm that the use of plasmapheresis and immunosuppression is a promising method of treatment in some patients with Goodpasture's syndrome. |
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In all patients, the antiglomerular basement-membrane antibody titers decreased with treatment. In three patients, hemoptysis responded promptly to plasmapheresis. Two patients presenting with severe renal failure required chronic dialysis, and three patients who had serum creatinine levels less than 2.1 mg/dl before treatment improved or had stabilization of their renal function. We confirm that the use of plasmapheresis and immunosuppression is a promising method of treatment in some patients with Goodpasture's syndrome.</description><identifier>ISSN: 0025-6196</identifier><identifier>PMID: 491763</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; Anti-Glomerular Basement Membrane Disease - immunology ; Anti-Glomerular Basement Membrane Disease - therapy ; Female ; Glomerulonephritis - therapy ; Hemoptysis - etiology ; Hemoptysis - therapy ; Hemorrhage - therapy ; Humans ; Immunosuppression ; Lung Diseases - therapy ; Male ; Middle Aged ; Plasmapheresis</subject><ispartof>Mayo Clinic proceedings, 1979-11, Vol.54 (11), p.714-720</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/491763$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Erickson, S B</creatorcontrib><creatorcontrib>Kurtz, S B</creatorcontrib><creatorcontrib>Donadio, Jr, J V</creatorcontrib><creatorcontrib>Holley, K E</creatorcontrib><creatorcontrib>Wilson, C B</creatorcontrib><creatorcontrib>Pineda, A A</creatorcontrib><title>Use of combined plasmapheresis and immunosuppression in the treatment of Goodpasture's syndrome</title><title>Mayo Clinic proceedings</title><addtitle>Mayo Clin Proc</addtitle><description>Five consecutive patients with well-documented Goodpasture's syndrome were treated with plasmapheresis and immunosuppression. In all patients, the antiglomerular basement-membrane antibody titers decreased with treatment. In three patients, hemoptysis responded promptly to plasmapheresis. Two patients presenting with severe renal failure required chronic dialysis, and three patients who had serum creatinine levels less than 2.1 mg/dl before treatment improved or had stabilization of their renal function. We confirm that the use of plasmapheresis and immunosuppression is a promising method of treatment in some patients with Goodpasture's syndrome.</description><subject>Adult</subject><subject>Anti-Glomerular Basement Membrane Disease - immunology</subject><subject>Anti-Glomerular Basement Membrane Disease - therapy</subject><subject>Female</subject><subject>Glomerulonephritis - therapy</subject><subject>Hemoptysis - etiology</subject><subject>Hemoptysis - therapy</subject><subject>Hemorrhage - therapy</subject><subject>Humans</subject><subject>Immunosuppression</subject><subject>Lung Diseases - therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Plasmapheresis</subject><issn>0025-6196</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotkDtPwzAURjPwKoV_wOAJpkiO40c8ogoKUiUWOkdOfKMaxQ98naH_nqJ2-qSjozN8V9WKUiZq2Wh5V90j_lBKldb8trrhulGyXVX9HoHEiYzRDy6AJWk26E06QAZ0SEywxHm_hIhLSieGLgbiAikHICWDKR5C-S9sY7TJYFkyvCDBY7A5enioriczIzxedl3t39--Nx_17mv7uXnd1YlRUepBUAqSGyYGazoOSktDGVVciqbrmgmUlEM3GRhFq1SjqJYUGNWguR1a0bbr6vncTTn-LoCl9w5HmGcTIC7YK66ElIydxKeLuAwebJ-y8yYf-_Mh7R9S0lxg</recordid><startdate>197911</startdate><enddate>197911</enddate><creator>Erickson, S B</creator><creator>Kurtz, S B</creator><creator>Donadio, Jr, J V</creator><creator>Holley, K E</creator><creator>Wilson, C B</creator><creator>Pineda, A A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>197911</creationdate><title>Use of combined plasmapheresis and immunosuppression in the treatment of Goodpasture's syndrome</title><author>Erickson, S B ; Kurtz, S B ; Donadio, Jr, J V ; Holley, K E ; Wilson, C B ; Pineda, A A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p205t-b500e64a25bda84e796a02074651881fe766b8faec5377170960e209e94db3533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Adult</topic><topic>Anti-Glomerular Basement Membrane Disease - immunology</topic><topic>Anti-Glomerular Basement Membrane Disease - therapy</topic><topic>Female</topic><topic>Glomerulonephritis - therapy</topic><topic>Hemoptysis - etiology</topic><topic>Hemoptysis - therapy</topic><topic>Hemorrhage - therapy</topic><topic>Humans</topic><topic>Immunosuppression</topic><topic>Lung Diseases - therapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Plasmapheresis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Erickson, S B</creatorcontrib><creatorcontrib>Kurtz, S B</creatorcontrib><creatorcontrib>Donadio, Jr, J V</creatorcontrib><creatorcontrib>Holley, K E</creatorcontrib><creatorcontrib>Wilson, C B</creatorcontrib><creatorcontrib>Pineda, A A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Mayo Clinic proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Erickson, S B</au><au>Kurtz, S B</au><au>Donadio, Jr, J V</au><au>Holley, K E</au><au>Wilson, C B</au><au>Pineda, A A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of combined plasmapheresis and immunosuppression in the treatment of Goodpasture's syndrome</atitle><jtitle>Mayo Clinic proceedings</jtitle><addtitle>Mayo Clin Proc</addtitle><date>1979-11</date><risdate>1979</risdate><volume>54</volume><issue>11</issue><spage>714</spage><epage>720</epage><pages>714-720</pages><issn>0025-6196</issn><abstract>Five consecutive patients with well-documented Goodpasture's syndrome were treated with plasmapheresis and immunosuppression. In all patients, the antiglomerular basement-membrane antibody titers decreased with treatment. In three patients, hemoptysis responded promptly to plasmapheresis. Two patients presenting with severe renal failure required chronic dialysis, and three patients who had serum creatinine levels less than 2.1 mg/dl before treatment improved or had stabilization of their renal function. We confirm that the use of plasmapheresis and immunosuppression is a promising method of treatment in some patients with Goodpasture's syndrome.</abstract><cop>England</cop><pmid>491763</pmid><tpages>7</tpages></addata></record> |
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| ispartof | Mayo Clinic proceedings, 1979-11, Vol.54 (11), p.714-720 |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Anti-Glomerular Basement Membrane Disease - immunology Anti-Glomerular Basement Membrane Disease - therapy Female Glomerulonephritis - therapy Hemoptysis - etiology Hemoptysis - therapy Hemorrhage - therapy Humans Immunosuppression Lung Diseases - therapy Male Middle Aged Plasmapheresis |
| title | Use of combined plasmapheresis and immunosuppression in the treatment of Goodpasture's syndrome |
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