Inhibition by angiotensin II of some vasopressin effects on renal function in sheep
The effects of intravenous infusions of arginine vasopressin (AVP) alone and with angiotensin II (AII) on renal function were studied in conscious Merino ewes. AVP at 11.5 pmol.min-1 caused an increase in water and electrolyte output which was associated with a rise in glomerular filtration rate (GF...
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| Veröffentlicht in: | Quarterly Journal of Experimental Physiology and Cognate Medical Sciences 1979-07, Vol.64 (3), p.161-168 |
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| container_title | Quarterly Journal of Experimental Physiology and Cognate Medical Sciences |
| container_volume | 64 |
| creator | Yesberg, N.E Henderson, M Budtz-Olsen, O.E |
| description | The effects of intravenous infusions of arginine vasopressin (AVP) alone and with angiotensin II (AII) on renal function were studied in conscious Merino ewes. AVP at 11.5 pmol.min-1 caused an increase in water and electrolyte output which was associated with a rise in glomerular filtration rate (GFR), solute clearance, solute-free water reabsorption and tubular sodium reabsorption. Addition of AII of 100 ng.min-1 generally reversed all of these effects. The filtration fraction, which rose during AVP infusion, increased further when AII was added due to a greater fall in renal plasma flow than in GFR. The diuretic and electrolyte-excreting effects of infused AVP appeared to be brought about by an increase in GFR. It is suggested that this inappropriate effect of AVP, which is secreted in response to water deprivation, could be countered by the simultaneous production of AII. |
| doi_str_mv | 10.1113/expphysiol.1979.sp002469 |
| format | Article |
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AVP at 11.5 pmol.min-1 caused an increase in water and electrolyte output which was associated with a rise in glomerular filtration rate (GFR), solute clearance, solute-free water reabsorption and tubular sodium reabsorption. Addition of AII of 100 ng.min-1 generally reversed all of these effects. The filtration fraction, which rose during AVP infusion, increased further when AII was added due to a greater fall in renal plasma flow than in GFR. The diuretic and electrolyte-excreting effects of infused AVP appeared to be brought about by an increase in GFR. 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AVP at 11.5 pmol.min-1 caused an increase in water and electrolyte output which was associated with a rise in glomerular filtration rate (GFR), solute clearance, solute-free water reabsorption and tubular sodium reabsorption. Addition of AII of 100 ng.min-1 generally reversed all of these effects. The filtration fraction, which rose during AVP infusion, increased further when AII was added due to a greater fall in renal plasma flow than in GFR. The diuretic and electrolyte-excreting effects of infused AVP appeared to be brought about by an increase in GFR. 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| identifier | ISSN: 0033-5541 |
| ispartof | Quarterly Journal of Experimental Physiology and Cognate Medical Sciences, 1979-07, Vol.64 (3), p.161-168 |
| issn | 0033-5541 1469-445X |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Angiotensin II - pharmacology animal science Animals Body Water - physiology Dose-Response Relationship, Drug Drug Therapy, Combination Female Glomerular Filtration Rate Kidney - blood supply Kidney - physiology livestock Regional Blood Flow - drug effects Sheep - physiology Sodium - physiology Vasopressins - antagonists & inhibitors zoology |
| title | Inhibition by angiotensin II of some vasopressin effects on renal function in sheep |
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