Structural Characteristics for Inhibition of [3H] Norepinephrine Uptake into Rat Brain Synaptic Vesicles by Beta-Carboline, Indolealkylamine, Phenethylamine and n-Alkylamine Derivatives

The abilities of four different classes of monoamines to inhibit uptake of [ 3 H]norepinephrine into rat brain synaptic vesicles were evaluated. Compounds from all four produced competitive inhibition with the following general order of potency: Î²-carbolines> indolealkylamines> phenalkylamine...

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Veröffentlicht in:	Molecular pharmacology 1979-05, Vol.15 (3), p.607-619
Hauptverfasser:	Slotkin, T A, Salvaggio, M, Seidler, F J, Whitmore, W L
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines - pharmacology Animals Brain - drug effects Brain - metabolism Carbolines - pharmacology In Vitro Techniques Indoles - pharmacology Kinetics Male Norepinephrine - metabolism Phenethylamines - pharmacology Rats Stereoisomerism Structure-Activity Relationship Synaptic Vesicles - drug effects Synaptic Vesicles - metabolism
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