Inhibition of dog renin activity by pepstatin A
The inhibitory effect of pepstatin A, an isovaleryl pentapeptide isolated from streptmyces, was studied. Pepstatin A inhibited the action of dog renin on homologus substrate. The Ki value was 7.7 X 10(-7) M and the mode of the inhibition was non-competitive. Pestatin A suppressed angiotensin I gener...
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| Veröffentlicht in: | Japanese circulation journal 1979-01, Vol.43 (9), p.818-823 |
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| container_end_page | 823 |
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| container_issue | 9 |
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| container_title | Japanese circulation journal |
| container_volume | 43 |
| creator | Miyazaki, M Komori, T Okunishi, H Toda, N |
| description | The inhibitory effect of pepstatin A, an isovaleryl pentapeptide isolated from streptmyces, was studied. Pepstatin A inhibited the action of dog renin on homologus substrate. The Ki value was 7.7 X 10(-7) M and the mode of the inhibition was non-competitive. Pestatin A suppressed angiotensin I generation in dog plasma. Dose-dependent hypotensive effect of pepstatin A was observed in rats with sustained increase in blood pressure during continuous infusion of dog renin. It is concluded that pepstatin A inhibits the dog renin activity in vitro and in vivo. |
| doi_str_mv | 10.1253/jcj.43.818 |
| format | Article |
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Pepstatin A inhibited the action of dog renin on homologus substrate. The Ki value was 7.7 X 10(-7) M and the mode of the inhibition was non-competitive. Pestatin A suppressed angiotensin I generation in dog plasma. Dose-dependent hypotensive effect of pepstatin A was observed in rats with sustained increase in blood pressure during continuous infusion of dog renin. It is concluded that pepstatin A inhibits the dog renin activity in vitro and in vivo.</description><identifier>ISSN: 0047-1828</identifier><identifier>EISSN: 1347-4839</identifier><identifier>DOI: 10.1253/jcj.43.818</identifier><identifier>PMID: 501901</identifier><language>eng</language><publisher>Japan</publisher><subject>Angiotensin I - biosynthesis ; Animals ; Blood Pressure - drug effects ; Dogs ; Dose-Response Relationship, Drug ; Oligopeptides - pharmacology ; Pepstatins - pharmacology ; Rats ; Renin - antagonists & inhibitors ; Renin - blood</subject><ispartof>Japanese circulation journal, 1979-01, Vol.43 (9), p.818-823</ispartof><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/501901$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miyazaki, M</creatorcontrib><creatorcontrib>Komori, T</creatorcontrib><creatorcontrib>Okunishi, H</creatorcontrib><creatorcontrib>Toda, N</creatorcontrib><title>Inhibition of dog renin activity by pepstatin A</title><title>Japanese circulation journal</title><addtitle>Jpn Circ J</addtitle><description>The inhibitory effect of pepstatin A, an isovaleryl pentapeptide isolated from streptmyces, was studied. Pepstatin A inhibited the action of dog renin on homologus substrate. The Ki value was 7.7 X 10(-7) M and the mode of the inhibition was non-competitive. Pestatin A suppressed angiotensin I generation in dog plasma. Dose-dependent hypotensive effect of pepstatin A was observed in rats with sustained increase in blood pressure during continuous infusion of dog renin. It is concluded that pepstatin A inhibits the dog renin activity in vitro and in vivo.</description><subject>Angiotensin I - biosynthesis</subject><subject>Animals</subject><subject>Blood Pressure - drug effects</subject><subject>Dogs</subject><subject>Dose-Response Relationship, Drug</subject><subject>Oligopeptides - pharmacology</subject><subject>Pepstatins - pharmacology</subject><subject>Rats</subject><subject>Renin - antagonists & inhibitors</subject><subject>Renin - blood</subject><issn>0047-1828</issn><issn>1347-4839</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kDtvwyAURlHVl5t26dzBU4dKTsBAgDGK-ogUqUs7I8DQYvlVgyvl34fKUaf70NF3dQ8A9wguUUnxqjb1kuAlR_wMZAgTVhCOxTnIIEw94iW_Bjch1BCWjFB6BS4pRAKiDKx23bfXPvq-y3uXV_1XPtrOd7ky0f_6eMj1IR_sEKKKabu5BRdONcHeneoCfL48f2zfiv3762672RcGCxELVTmERLplLaNCrAVxzOg0lVoT7hBljBqlIDFViTlXFcGu4lBguDYaO4YX4HHOHcb-Z7IhytYHY5tGdbafgmSE0fQMTODTDJqxD2G0Tg6jb9V4kAjKPzkyyZEEyyQnwQ-n1Em3tvpHZxv4CDVxXmU</recordid><startdate>19790101</startdate><enddate>19790101</enddate><creator>Miyazaki, M</creator><creator>Komori, T</creator><creator>Okunishi, H</creator><creator>Toda, N</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19790101</creationdate><title>Inhibition of dog renin activity by pepstatin A</title><author>Miyazaki, M ; Komori, T ; Okunishi, H ; Toda, N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-adf119745ee7599694f7cb5ee2bb48f15775caa04cd2388ad43fd809306cb3f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Angiotensin I - biosynthesis</topic><topic>Animals</topic><topic>Blood Pressure - drug effects</topic><topic>Dogs</topic><topic>Dose-Response Relationship, Drug</topic><topic>Oligopeptides - pharmacology</topic><topic>Pepstatins - pharmacology</topic><topic>Rats</topic><topic>Renin - antagonists & inhibitors</topic><topic>Renin - blood</topic><toplevel>online_resources</toplevel><creatorcontrib>Miyazaki, M</creatorcontrib><creatorcontrib>Komori, T</creatorcontrib><creatorcontrib>Okunishi, H</creatorcontrib><creatorcontrib>Toda, N</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese circulation journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miyazaki, M</au><au>Komori, T</au><au>Okunishi, H</au><au>Toda, N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of dog renin activity by pepstatin A</atitle><jtitle>Japanese circulation journal</jtitle><addtitle>Jpn Circ J</addtitle><date>1979-01-01</date><risdate>1979</risdate><volume>43</volume><issue>9</issue><spage>818</spage><epage>823</epage><pages>818-823</pages><issn>0047-1828</issn><eissn>1347-4839</eissn><abstract>The inhibitory effect of pepstatin A, an isovaleryl pentapeptide isolated from streptmyces, was studied. 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| fulltext | fulltext |
| identifier | ISSN: 0047-1828 |
| ispartof | Japanese circulation journal, 1979-01, Vol.43 (9), p.818-823 |
| issn | 0047-1828 1347-4839 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74750270 |
| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | Angiotensin I - biosynthesis Animals Blood Pressure - drug effects Dogs Dose-Response Relationship, Drug Oligopeptides - pharmacology Pepstatins - pharmacology Rats Renin - antagonists & inhibitors Renin - blood |
| title | Inhibition of dog renin activity by pepstatin A |
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