Prognostic significance of the histological features of malignant melanoma
A review of 694 patients with localized cutaneous malignant melanoma (clinical stage I) revealed that three histological features of the primary lesion had no effect of their own on survival rate but derived their prognostic significance only because of their close correlation with tumour thickness....
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| Veröffentlicht in: | Histopathology 1979-09, Vol.3 (5), p.385-393 |
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| container_title | Histopathology |
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| creator | MCGOVERN, V. J. SHAW, H. M. MILTON, G. W. FARAGO, G. A. |
| description | A review of 694 patients with localized cutaneous malignant melanoma (clinical stage I) revealed that three histological features of the primary lesion had no effect of their own on survival rate but derived their prognostic significance only because of their close correlation with tumour thickness. Primary lesions of superficial spreading histogenetic type, or of low mitotic activity or showing evidence of partial regression appeared to have a more favourable prognosis than lesions of nodular histogenetic type or of high mitotic activity or showing no regression. However, the former three histological features were predominant in thin lesions which had a better prognosis than thicker lesions. It was concluded that these features exerted only an indirect effect upon survival, tumour thickness being the most important prognostic determinant. |
| doi_str_mv | 10.1111/j.1365-2559.1979.tb03020.x |
| format | Article |
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It was concluded that these features exerted only an indirect effect upon survival, tumour thickness being the most important prognostic determinant.</description><identifier>ISSN: 0309-0167</identifier><identifier>EISSN: 1365-2559</identifier><identifier>DOI: 10.1111/j.1365-2559.1979.tb03020.x</identifier><identifier>PMID: 488922</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Humans ; malignant melanoma ; Melanoma - diagnosis ; Melanoma - pathology ; mitotic activity ; Neoplasm Staging ; nodular melanoma ; Prognosis ; regression ; superficial spreading melanoma ; tumour thickness</subject><ispartof>Histopathology, 1979-09, Vol.3 (5), p.385-393</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4725-9677a510c37a55bc23369fd78225c6e7d02a75c9fdb54f386472e9a26a427e713</citedby><cites>FETCH-LOGICAL-c4725-9677a510c37a55bc23369fd78225c6e7d02a75c9fdb54f386472e9a26a427e713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2559.1979.tb03020.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2559.1979.tb03020.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/488922$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MCGOVERN, V. 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However, the former three histological features were predominant in thin lesions which had a better prognosis than thicker lesions. It was concluded that these features exerted only an indirect effect upon survival, tumour thickness being the most important prognostic determinant.</description><subject>Humans</subject><subject>malignant melanoma</subject><subject>Melanoma - diagnosis</subject><subject>Melanoma - pathology</subject><subject>mitotic activity</subject><subject>Neoplasm Staging</subject><subject>nodular melanoma</subject><subject>Prognosis</subject><subject>regression</subject><subject>superficial spreading melanoma</subject><subject>tumour thickness</subject><issn>0309-0167</issn><issn>1365-2559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkMlOwzAQhi3EVgpvwCHiwC3BS2zHHJCggi6qChIgjpbrOm1KEpc4Ee3b4yhV7_gy0vzLWB8ANwhGyL-7dYQIoyGmVERIcBHVc0gghtH2CPQO0jHo-a0IIWL8HFw4t4YQcYLxGTiNk0Rg3AOTt8ouS-vqTAcuW5ZZmmlVahPYNKhXJlhlrra5XfptHqRG1U1lXCsWKvd2VdZBYXJV2kJdgpNU5c5c7WcffL48fwxG4fR1OB48TkMdc0xDwThXFEFN_KBzjQlhIl3wBGOqmeELiBWn2q_mNE5JwnzKCIWZijE3HJE-uO16N5X9aYyrZZE5bXL_C2MbJ3nM44Tx2BvvO6OurHOVSeWmygpV7SSCsuUo17KFJVtYsuUo9xzl1oev91eaeWEWh2gHzssPnfyb5Wb3j2I5Gr-ThPqCsCvwgM32UKCqb8k44VR-zYbyacYmYhQPJSV_bSqRiQ</recordid><startdate>197909</startdate><enddate>197909</enddate><creator>MCGOVERN, V. J.</creator><creator>SHAW, H. M.</creator><creator>MILTON, G. W.</creator><creator>FARAGO, G. A.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197909</creationdate><title>Prognostic significance of the histological features of malignant melanoma</title><author>MCGOVERN, V. J. ; SHAW, H. M. ; MILTON, G. W. ; FARAGO, G. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4725-9677a510c37a55bc23369fd78225c6e7d02a75c9fdb54f386472e9a26a427e713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Humans</topic><topic>malignant melanoma</topic><topic>Melanoma - diagnosis</topic><topic>Melanoma - pathology</topic><topic>mitotic activity</topic><topic>Neoplasm Staging</topic><topic>nodular melanoma</topic><topic>Prognosis</topic><topic>regression</topic><topic>superficial spreading melanoma</topic><topic>tumour thickness</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MCGOVERN, V. J.</creatorcontrib><creatorcontrib>SHAW, H. M.</creatorcontrib><creatorcontrib>MILTON, G. W.</creatorcontrib><creatorcontrib>FARAGO, G. 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A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic significance of the histological features of malignant melanoma</atitle><jtitle>Histopathology</jtitle><addtitle>Histopathology</addtitle><date>1979-09</date><risdate>1979</risdate><volume>3</volume><issue>5</issue><spage>385</spage><epage>393</epage><pages>385-393</pages><issn>0309-0167</issn><eissn>1365-2559</eissn><abstract>A review of 694 patients with localized cutaneous malignant melanoma (clinical stage I) revealed that three histological features of the primary lesion had no effect of their own on survival rate but derived their prognostic significance only because of their close correlation with tumour thickness. Primary lesions of superficial spreading histogenetic type, or of low mitotic activity or showing evidence of partial regression appeared to have a more favourable prognosis than lesions of nodular histogenetic type or of high mitotic activity or showing no regression. However, the former three histological features were predominant in thin lesions which had a better prognosis than thicker lesions. It was concluded that these features exerted only an indirect effect upon survival, tumour thickness being the most important prognostic determinant.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>488922</pmid><doi>10.1111/j.1365-2559.1979.tb03020.x</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0309-0167 |
| ispartof | Histopathology, 1979-09, Vol.3 (5), p.385-393 |
| issn | 0309-0167 1365-2559 |
| language | eng |
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| source | MEDLINE; Wiley Journals |
| subjects | Humans malignant melanoma Melanoma - diagnosis Melanoma - pathology mitotic activity Neoplasm Staging nodular melanoma Prognosis regression superficial spreading melanoma tumour thickness |
| title | Prognostic significance of the histological features of malignant melanoma |
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