On the morphological evaluation of the neurovirulence safety of attenuated mumps virus strains in monkeys
In tests with intracerebral inoculation of Macacus rhesus, the neurovirulent properties of two variants of attenuated mumps virus, obtained at different passage levels (19th and 22nd) in the primary cultures of guinea-pig kidney and Japanese quail embryo fibroblast cells, were studied. Neither varia...
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| Veröffentlicht in: | Journal of biological standardization 1979, Vol.7 (1), p.9,IN1,12-11,IN5,19 |
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| creator | Levenbuk, I.S. Nikolayeva, M.A. Chigirinsky, A.E. Ralf, N.M. Kozlov, V.G. Vardanyan, N.V. Sliopushkina, V.G. Kolomiets, O.L. Rukhamina, M.L. Grigoryeva, L.V. |
| description | In tests with intracerebral inoculation of
Macacus rhesus, the neurovirulent properties of two variants of attenuated mumps virus, obtained at different passage levels (19th and 22nd) in the primary cultures of guinea-pig kidney and Japanese quail embryo fibroblast cells, were studied. Neither variants damaged the neurons, but caused ventriculitis phenomena, often most pronounced in the posterior portions of central parts of lateral ventricles, i.e. far from the site of virus inoculation. By the immunofluorescent method the specificity of the pathological process was confirmed: the antigen mostly detected in the ependyma, the subependymal zone, in the cells of inflammatory infiltrates located in this zone and in the stroma of choroid plexus, as well as in a number of neurons in the insular cortex area.
Tests revealed that the neurovirulent properties are enhanced in the higher passage level variant, after the inoculation in which some monkeys developed a picture of adhesive ventriculitis, sometimes up to an almost complete obliteration of the ventricle lumen.
Attention is drawn to the necessity of investigating the brain ventricular system when attenuated strains—candidates for live mumps vaccines—are studied in the neurovirulence safety test in monkeys. |
| doi_str_mv | 10.1016/S0092-1157(79)80033-5 |
| format | Article |
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Macacus rhesus, the neurovirulent properties of two variants of attenuated mumps virus, obtained at different passage levels (19th and 22nd) in the primary cultures of guinea-pig kidney and Japanese quail embryo fibroblast cells, were studied. Neither variants damaged the neurons, but caused ventriculitis phenomena, often most pronounced in the posterior portions of central parts of lateral ventricles, i.e. far from the site of virus inoculation. By the immunofluorescent method the specificity of the pathological process was confirmed: the antigen mostly detected in the ependyma, the subependymal zone, in the cells of inflammatory infiltrates located in this zone and in the stroma of choroid plexus, as well as in a number of neurons in the insular cortex area.
Tests revealed that the neurovirulent properties are enhanced in the higher passage level variant, after the inoculation in which some monkeys developed a picture of adhesive ventriculitis, sometimes up to an almost complete obliteration of the ventricle lumen.
Attention is drawn to the necessity of investigating the brain ventricular system when attenuated strains—candidates for live mumps vaccines—are studied in the neurovirulence safety test in monkeys.</description><identifier>ISSN: 0092-1157</identifier><identifier>DOI: 10.1016/S0092-1157(79)80033-5</identifier><identifier>PMID: 114528</identifier><language>eng</language><publisher>England: Elsevier Science (USA)</publisher><subject>Animals ; Antigens, Viral - analysis ; Central Nervous System - immunology ; Central Nervous System - microbiology ; Evaluation Studies as Topic ; Haplorhini ; Histological Techniques ; Immunologic Techniques ; Injections, Intraventricular ; Macaca ; Mumps Vaccine - administration & dosage ; Mumps Vaccine - standards ; Mumps virus - pathogenicity ; Virus Cultivation - methods</subject><ispartof>Journal of biological standardization, 1979, Vol.7 (1), p.9,IN1,12-11,IN5,19</ispartof><rights>1979 The International Association of Biological Standardization</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-11194398721b8ac40e6b9f0935cbdffeff2dd97bdc7b9b0165285433b08a13f23</citedby><cites>FETCH-LOGICAL-c359t-11194398721b8ac40e6b9f0935cbdffeff2dd97bdc7b9b0165285433b08a13f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/114528$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Levenbuk, I.S.</creatorcontrib><creatorcontrib>Nikolayeva, M.A.</creatorcontrib><creatorcontrib>Chigirinsky, A.E.</creatorcontrib><creatorcontrib>Ralf, N.M.</creatorcontrib><creatorcontrib>Kozlov, V.G.</creatorcontrib><creatorcontrib>Vardanyan, N.V.</creatorcontrib><creatorcontrib>Sliopushkina, V.G.</creatorcontrib><creatorcontrib>Kolomiets, O.L.</creatorcontrib><creatorcontrib>Rukhamina, M.L.</creatorcontrib><creatorcontrib>Grigoryeva, L.V.</creatorcontrib><title>On the morphological evaluation of the neurovirulence safety of attenuated mumps virus strains in monkeys</title><title>Journal of biological standardization</title><addtitle>J Biol Stand</addtitle><description>In tests with intracerebral inoculation of
Macacus rhesus, the neurovirulent properties of two variants of attenuated mumps virus, obtained at different passage levels (19th and 22nd) in the primary cultures of guinea-pig kidney and Japanese quail embryo fibroblast cells, were studied. Neither variants damaged the neurons, but caused ventriculitis phenomena, often most pronounced in the posterior portions of central parts of lateral ventricles, i.e. far from the site of virus inoculation. By the immunofluorescent method the specificity of the pathological process was confirmed: the antigen mostly detected in the ependyma, the subependymal zone, in the cells of inflammatory infiltrates located in this zone and in the stroma of choroid plexus, as well as in a number of neurons in the insular cortex area.
Tests revealed that the neurovirulent properties are enhanced in the higher passage level variant, after the inoculation in which some monkeys developed a picture of adhesive ventriculitis, sometimes up to an almost complete obliteration of the ventricle lumen.
Attention is drawn to the necessity of investigating the brain ventricular system when attenuated strains—candidates for live mumps vaccines—are studied in the neurovirulence safety test in monkeys.</description><subject>Animals</subject><subject>Antigens, Viral - analysis</subject><subject>Central Nervous System - immunology</subject><subject>Central Nervous System - microbiology</subject><subject>Evaluation Studies as Topic</subject><subject>Haplorhini</subject><subject>Histological Techniques</subject><subject>Immunologic Techniques</subject><subject>Injections, Intraventricular</subject><subject>Macaca</subject><subject>Mumps Vaccine - administration & dosage</subject><subject>Mumps Vaccine - standards</subject><subject>Mumps virus - pathogenicity</subject><subject>Virus Cultivation - methods</subject><issn>0092-1157</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkElPwzAQhX1gK8s_AMknBIeCHcdNfEKoYpMq9QCcLccZU0NiF9up1H9P0lZw5DTSvDfL-xC6oOSGEjq5fSVEZGNKeXFViOuSEMbGfA-NfttH6DjGT0KyMuflITqgNOdZOUJ27nBaAG59WC584z-sVg2GlWo6lax32JuN7qALfmVD14DTgKMykNaDqFIC13uhxm3XLiMeTBHHFJR1EVvXr3ZfsI6naN-oJsLZrp6g98eHt-nzeDZ_epnez8aacZH6Z6nImSiLjFal0jmBSSUMEYzrqjYGjMnqWhRVrYtKVH32PgbPGatIqSgzGTtBl9u9y-C_O4hJtjZqaBrlwHdRFnmRZ0zw3si3Rh18jAGMXAbbqrCWlMiBqtxQlQM-WQi5oSqHufPdga5qof6b2iDt5butDH3IlYUgo7YDtNoG0EnW3v5z4Ad9yYss</recordid><startdate>1979</startdate><enddate>1979</enddate><creator>Levenbuk, I.S.</creator><creator>Nikolayeva, M.A.</creator><creator>Chigirinsky, A.E.</creator><creator>Ralf, N.M.</creator><creator>Kozlov, V.G.</creator><creator>Vardanyan, N.V.</creator><creator>Sliopushkina, V.G.</creator><creator>Kolomiets, O.L.</creator><creator>Rukhamina, M.L.</creator><creator>Grigoryeva, L.V.</creator><general>Elsevier Science (USA)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1979</creationdate><title>On the morphological evaluation of the neurovirulence safety of attenuated mumps virus strains in monkeys</title><author>Levenbuk, I.S. ; Nikolayeva, M.A. ; Chigirinsky, A.E. ; Ralf, N.M. ; Kozlov, V.G. ; Vardanyan, N.V. ; Sliopushkina, V.G. ; Kolomiets, O.L. ; Rukhamina, M.L. ; Grigoryeva, L.V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-11194398721b8ac40e6b9f0935cbdffeff2dd97bdc7b9b0165285433b08a13f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Animals</topic><topic>Antigens, Viral - analysis</topic><topic>Central Nervous System - immunology</topic><topic>Central Nervous System - microbiology</topic><topic>Evaluation Studies as Topic</topic><topic>Haplorhini</topic><topic>Histological Techniques</topic><topic>Immunologic Techniques</topic><topic>Injections, Intraventricular</topic><topic>Macaca</topic><topic>Mumps Vaccine - administration & dosage</topic><topic>Mumps Vaccine - standards</topic><topic>Mumps virus - pathogenicity</topic><topic>Virus Cultivation - methods</topic><toplevel>online_resources</toplevel><creatorcontrib>Levenbuk, I.S.</creatorcontrib><creatorcontrib>Nikolayeva, M.A.</creatorcontrib><creatorcontrib>Chigirinsky, A.E.</creatorcontrib><creatorcontrib>Ralf, N.M.</creatorcontrib><creatorcontrib>Kozlov, V.G.</creatorcontrib><creatorcontrib>Vardanyan, N.V.</creatorcontrib><creatorcontrib>Sliopushkina, V.G.</creatorcontrib><creatorcontrib>Kolomiets, O.L.</creatorcontrib><creatorcontrib>Rukhamina, M.L.</creatorcontrib><creatorcontrib>Grigoryeva, L.V.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biological standardization</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Levenbuk, I.S.</au><au>Nikolayeva, M.A.</au><au>Chigirinsky, A.E.</au><au>Ralf, N.M.</au><au>Kozlov, V.G.</au><au>Vardanyan, N.V.</au><au>Sliopushkina, V.G.</au><au>Kolomiets, O.L.</au><au>Rukhamina, M.L.</au><au>Grigoryeva, L.V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>On the morphological evaluation of the neurovirulence safety of attenuated mumps virus strains in monkeys</atitle><jtitle>Journal of biological standardization</jtitle><addtitle>J Biol Stand</addtitle><date>1979</date><risdate>1979</risdate><volume>7</volume><issue>1</issue><spage>9,IN1,12</spage><epage>11,IN5,19</epage><pages>9,IN1,12-11,IN5,19</pages><issn>0092-1157</issn><abstract>In tests with intracerebral inoculation of
Macacus rhesus, the neurovirulent properties of two variants of attenuated mumps virus, obtained at different passage levels (19th and 22nd) in the primary cultures of guinea-pig kidney and Japanese quail embryo fibroblast cells, were studied. Neither variants damaged the neurons, but caused ventriculitis phenomena, often most pronounced in the posterior portions of central parts of lateral ventricles, i.e. far from the site of virus inoculation. By the immunofluorescent method the specificity of the pathological process was confirmed: the antigen mostly detected in the ependyma, the subependymal zone, in the cells of inflammatory infiltrates located in this zone and in the stroma of choroid plexus, as well as in a number of neurons in the insular cortex area.
Tests revealed that the neurovirulent properties are enhanced in the higher passage level variant, after the inoculation in which some monkeys developed a picture of adhesive ventriculitis, sometimes up to an almost complete obliteration of the ventricle lumen.
Attention is drawn to the necessity of investigating the brain ventricular system when attenuated strains—candidates for live mumps vaccines—are studied in the neurovirulence safety test in monkeys.</abstract><cop>England</cop><pub>Elsevier Science (USA)</pub><pmid>114528</pmid><doi>10.1016/S0092-1157(79)80033-5</doi><tpages>11</tpages></addata></record> |
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| subjects | Animals Antigens, Viral - analysis Central Nervous System - immunology Central Nervous System - microbiology Evaluation Studies as Topic Haplorhini Histological Techniques Immunologic Techniques Injections, Intraventricular Macaca Mumps Vaccine - administration & dosage Mumps Vaccine - standards Mumps virus - pathogenicity Virus Cultivation - methods |
| title | On the morphological evaluation of the neurovirulence safety of attenuated mumps virus strains in monkeys |
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