Naloxone-induced contracture of ileum from stressed guinea pigs
The in vitro preparation of guinea-pig ileum taken from animals which had been stressed by swimming for 5 min in water at 20°C responded by a dose-dependent contracture to the narcotic antagonist naloxone. This response was antagonised by atropine (8 × 10 −8 g/ml). Ileum preparations from non-stress...
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| Veröffentlicht in: | European journal of pharmacology 1979-08, Vol.57 (2), p.259-261 |
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| container_title | European journal of pharmacology |
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| creator | J. Bodycote, Ian Chesher, Gregory B. |
| description | The in vitro preparation of guinea-pig ileum taken from animals which had been stressed by swimming for 5 min in water at 20°C responded by a dose-dependent contracture to the narcotic antagonist naloxone. This response was antagonised by atropine (8 × 10
−8 g/ml). Ileum preparations from non-stressed guinea pigs did not respond to naloxone in concentrations up to 1 × 10
−5 g/ml. The possibility that this response is a consequence of the stress-induced release of endogenous opiate peptides is discussed. |
| doi_str_mv | 10.1016/0014-2999(79)90375-3 |
| format | Article |
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−8 g/ml). Ileum preparations from non-stressed guinea pigs did not respond to naloxone in concentrations up to 1 × 10
−5 g/ml. The possibility that this response is a consequence of the stress-induced release of endogenous opiate peptides is discussed.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/0014-2999(79)90375-3</identifier><identifier>PMID: 573693</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Acetylcholine - metabolism ; Animals ; Atropine - pharmacology ; Guinea Pigs ; Guinea-pig ileum ; Histamine - pharmacology ; Humans ; In Vitro Techniques ; Muscle Contraction - drug effects ; Muscle, Smooth - drug effects ; Naloxone ; Naloxone - pharmacology ; Stress ; Stress, Psychological - physiopathology ; Swimming ; β-Endorphin</subject><ispartof>European journal of pharmacology, 1979-08, Vol.57 (2), p.259-261</ispartof><rights>1979</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-8d0c243ccef42bc3593a3c651c1bf30c073abad73664f03bf9a4039239d4ee4e3</citedby><cites>FETCH-LOGICAL-c356t-8d0c243ccef42bc3593a3c651c1bf30c073abad73664f03bf9a4039239d4ee4e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0014-2999(79)90375-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/573693$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>J. Bodycote, Ian</creatorcontrib><creatorcontrib>Chesher, Gregory B.</creatorcontrib><title>Naloxone-induced contracture of ileum from stressed guinea pigs</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>The in vitro preparation of guinea-pig ileum taken from animals which had been stressed by swimming for 5 min in water at 20°C responded by a dose-dependent contracture to the narcotic antagonist naloxone. This response was antagonised by atropine (8 × 10
−8 g/ml). Ileum preparations from non-stressed guinea pigs did not respond to naloxone in concentrations up to 1 × 10
−5 g/ml. The possibility that this response is a consequence of the stress-induced release of endogenous opiate peptides is discussed.</description><subject>Acetylcholine - metabolism</subject><subject>Animals</subject><subject>Atropine - pharmacology</subject><subject>Guinea Pigs</subject><subject>Guinea-pig ileum</subject><subject>Histamine - pharmacology</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscle, Smooth - drug effects</subject><subject>Naloxone</subject><subject>Naloxone - pharmacology</subject><subject>Stress</subject><subject>Stress, Psychological - physiopathology</subject><subject>Swimming</subject><subject>β-Endorphin</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kDtPwzAQxy3EqxS-QYdMCIaAnXPiegGhipdUwQKz5TjnyiiJi50g-PakpOrIdNL9H7r7ETJj9IpRVlxTyniaSSkvhLyUFESewh6ZsLmQKRUs2yeTneWYnMT4QSnNZZYfkcNcQCFhQm5fdO2_fYupa6veYJUY33ZBm64PmHibuBr7JrHBN0nsAsY4WFa9a1Ena7eKp-TA6jri2XZOyfvD_dviKV2-Pj4v7papgbzo0nlFTcbBGLQ8K4edBA2myJlhpQVqqABd6mo4quCWQmml5hRkBrLiiBxhSs7H3nXwnz3GTjUuGqxr3aLvoxJcAJe8GIx8NJrgYwxo1Tq4RocfxajaYFMbJmrDRAmp_rApGGKzbX9fNljtQiOnQb4ZZRx-_HIYVDQO24GXC2g6VXn3f_8vQXZ8PQ</recordid><startdate>19790801</startdate><enddate>19790801</enddate><creator>J. Bodycote, Ian</creator><creator>Chesher, Gregory B.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19790801</creationdate><title>Naloxone-induced contracture of ileum from stressed guinea pigs</title><author>J. Bodycote, Ian ; Chesher, Gregory B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-8d0c243ccef42bc3593a3c651c1bf30c073abad73664f03bf9a4039239d4ee4e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Acetylcholine - metabolism</topic><topic>Animals</topic><topic>Atropine - pharmacology</topic><topic>Guinea Pigs</topic><topic>Guinea-pig ileum</topic><topic>Histamine - pharmacology</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Muscle Contraction - drug effects</topic><topic>Muscle, Smooth - drug effects</topic><topic>Naloxone</topic><topic>Naloxone - pharmacology</topic><topic>Stress</topic><topic>Stress, Psychological - physiopathology</topic><topic>Swimming</topic><topic>β-Endorphin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>J. Bodycote, Ian</creatorcontrib><creatorcontrib>Chesher, Gregory B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>J. Bodycote, Ian</au><au>Chesher, Gregory B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Naloxone-induced contracture of ileum from stressed guinea pigs</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1979-08-01</date><risdate>1979</risdate><volume>57</volume><issue>2</issue><spage>259</spage><epage>261</epage><pages>259-261</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><abstract>The in vitro preparation of guinea-pig ileum taken from animals which had been stressed by swimming for 5 min in water at 20°C responded by a dose-dependent contracture to the narcotic antagonist naloxone. This response was antagonised by atropine (8 × 10
−8 g/ml). Ileum preparations from non-stressed guinea pigs did not respond to naloxone in concentrations up to 1 × 10
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| fulltext | fulltext |
| identifier | ISSN: 0014-2999 |
| ispartof | European journal of pharmacology, 1979-08, Vol.57 (2), p.259-261 |
| issn | 0014-2999 1879-0712 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acetylcholine - metabolism Animals Atropine - pharmacology Guinea Pigs Guinea-pig ileum Histamine - pharmacology Humans In Vitro Techniques Muscle Contraction - drug effects Muscle, Smooth - drug effects Naloxone Naloxone - pharmacology Stress Stress, Psychological - physiopathology Swimming β-Endorphin |
| title | Naloxone-induced contracture of ileum from stressed guinea pigs |
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