Evaluation of Timolol Maleate Combination Therapy in Chronic Open-Angle Glaucoma
In an eight-week study, timolol maleate ophthalmic solution 0.25% was administered twice daily with either pilocarpine 2% four times a day, epinephrine 2% twice a day, carbachol 1.5% four times a day, or 250 mg of acetazolamide twice a day to 44 patients with chronic open-angle glaucoma. Compared to...
Gespeichert in:
| Veröffentlicht in: | American journal of ophthalmology 1979-09, Vol.88 (3), p.565-571 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 571 |
|---|---|
| container_issue | 3 |
| container_start_page | 565 |
| container_title | American journal of ophthalmology |
| container_volume | 88 |
| creator | Keates, Edwin U. |
| description | In an eight-week study, timolol maleate ophthalmic solution 0.25% was administered twice daily with either pilocarpine 2% four times a day, epinephrine 2% twice a day, carbachol 1.5% four times a day, or 250 mg of acetazolamide twice a day to 44 patients with chronic open-angle glaucoma. Compared to baseline readings on standard therapy alone, mean intraocular pressure was significantly reduced after addition of timolol maleate to each of the regimens. Mean facility of outflow was unaffected. No clinically significant ocular irritation or changes in visual acuity, pupil size, or vital signs were observed in any patient. Timolol maleate appears to be effective and well tolerated when administered with other antiglaucoma medications in patients with open-angle glaucoma. |
| doi_str_mv | 10.1016/0002-9394(79)90516-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_74732709</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0002939479905166</els_id><sourcerecordid>74732709</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-21841e6584461fe5866851cdeec29f43907293e31fab8f52009edef0cea28ce33</originalsourceid><addsrcrecordid>eNp9kE1LwzAYx4P4NqffYIeeRA_VpE3T5CKMMqcwmYd5Dln61EXSZibtYN_ezg6Pnh4e_i_w_yE0IfiBYMIeMcZJLFJB73JxL3BGWMxO0IjwXMSEC3KKRn-WS3QVwlf_spzmF-iccsp4PkLvs52ynWqNayJXRStTO-ts9KYsqBaiwtVr0wzyagNebfeRaaJi411jdLTcQhNPm08L0dyqTrtaXaOzStkAN8c7Rh_Ps1XxEi-W89diuoh1mrE2TginBFjGKWWkgowzxjOiSwCdiIqmAueJSCEllVrzKkswFlBChTWohGtI0zG6HXq33n13EFpZm6DBWtWA64LsZ6ZJjkVvpINRexeCh0puvamV30uC5YGjPECSB0gyF_KXo2R9bHLs79Y1lH-hAVwvPw0y9Bt3BrwM2kCjoTQedCtLZ_7v_wGMfYEm</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>74732709</pqid></control><display><type>article</type><title>Evaluation of Timolol Maleate Combination Therapy in Chronic Open-Angle Glaucoma</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Keates, Edwin U.</creator><creatorcontrib>Keates, Edwin U.</creatorcontrib><description>In an eight-week study, timolol maleate ophthalmic solution 0.25% was administered twice daily with either pilocarpine 2% four times a day, epinephrine 2% twice a day, carbachol 1.5% four times a day, or 250 mg of acetazolamide twice a day to 44 patients with chronic open-angle glaucoma. Compared to baseline readings on standard therapy alone, mean intraocular pressure was significantly reduced after addition of timolol maleate to each of the regimens. Mean facility of outflow was unaffected. No clinically significant ocular irritation or changes in visual acuity, pupil size, or vital signs were observed in any patient. Timolol maleate appears to be effective and well tolerated when administered with other antiglaucoma medications in patients with open-angle glaucoma.</description><identifier>ISSN: 0002-9394</identifier><identifier>EISSN: 1879-1891</identifier><identifier>DOI: 10.1016/0002-9394(79)90516-6</identifier><identifier>PMID: 484687</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject><![CDATA[Acetazolamide - administration & dosage ; Adult ; Aged ; Carbachol - administration & dosage ; Drug Therapy, Combination ; Epinephrine - administration & dosage ; Female ; Glaucoma - drug therapy ; Glaucoma - physiopathology ; Humans ; Intraocular Pressure ; Male ; Middle Aged ; Pilocarpine - administration & dosage ; Propanolamines - administration & dosage ; Timolol - administration & dosage]]></subject><ispartof>American journal of ophthalmology, 1979-09, Vol.88 (3), p.565-571</ispartof><rights>1979 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-21841e6584461fe5866851cdeec29f43907293e31fab8f52009edef0cea28ce33</citedby><cites>FETCH-LOGICAL-c356t-21841e6584461fe5866851cdeec29f43907293e31fab8f52009edef0cea28ce33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0002939479905166$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/484687$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Keates, Edwin U.</creatorcontrib><title>Evaluation of Timolol Maleate Combination Therapy in Chronic Open-Angle Glaucoma</title><title>American journal of ophthalmology</title><addtitle>Am J Ophthalmol</addtitle><description>In an eight-week study, timolol maleate ophthalmic solution 0.25% was administered twice daily with either pilocarpine 2% four times a day, epinephrine 2% twice a day, carbachol 1.5% four times a day, or 250 mg of acetazolamide twice a day to 44 patients with chronic open-angle glaucoma. Compared to baseline readings on standard therapy alone, mean intraocular pressure was significantly reduced after addition of timolol maleate to each of the regimens. Mean facility of outflow was unaffected. No clinically significant ocular irritation or changes in visual acuity, pupil size, or vital signs were observed in any patient. Timolol maleate appears to be effective and well tolerated when administered with other antiglaucoma medications in patients with open-angle glaucoma.</description><subject>Acetazolamide - administration & dosage</subject><subject>Adult</subject><subject>Aged</subject><subject>Carbachol - administration & dosage</subject><subject>Drug Therapy, Combination</subject><subject>Epinephrine - administration & dosage</subject><subject>Female</subject><subject>Glaucoma - drug therapy</subject><subject>Glaucoma - physiopathology</subject><subject>Humans</subject><subject>Intraocular Pressure</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pilocarpine - administration & dosage</subject><subject>Propanolamines - administration & dosage</subject><subject>Timolol - administration & dosage</subject><issn>0002-9394</issn><issn>1879-1891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LwzAYx4P4NqffYIeeRA_VpE3T5CKMMqcwmYd5Dln61EXSZibtYN_ezg6Pnh4e_i_w_yE0IfiBYMIeMcZJLFJB73JxL3BGWMxO0IjwXMSEC3KKRn-WS3QVwlf_spzmF-iccsp4PkLvs52ynWqNayJXRStTO-ts9KYsqBaiwtVr0wzyagNebfeRaaJi411jdLTcQhNPm08L0dyqTrtaXaOzStkAN8c7Rh_Ps1XxEi-W89diuoh1mrE2TginBFjGKWWkgowzxjOiSwCdiIqmAueJSCEllVrzKkswFlBChTWohGtI0zG6HXq33n13EFpZm6DBWtWA64LsZ6ZJjkVvpINRexeCh0puvamV30uC5YGjPECSB0gyF_KXo2R9bHLs79Y1lH-hAVwvPw0y9Bt3BrwM2kCjoTQedCtLZ_7v_wGMfYEm</recordid><startdate>197909</startdate><enddate>197909</enddate><creator>Keates, Edwin U.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197909</creationdate><title>Evaluation of Timolol Maleate Combination Therapy in Chronic Open-Angle Glaucoma</title><author>Keates, Edwin U.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-21841e6584461fe5866851cdeec29f43907293e31fab8f52009edef0cea28ce33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Acetazolamide - administration & dosage</topic><topic>Adult</topic><topic>Aged</topic><topic>Carbachol - administration & dosage</topic><topic>Drug Therapy, Combination</topic><topic>Epinephrine - administration & dosage</topic><topic>Female</topic><topic>Glaucoma - drug therapy</topic><topic>Glaucoma - physiopathology</topic><topic>Humans</topic><topic>Intraocular Pressure</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pilocarpine - administration & dosage</topic><topic>Propanolamines - administration & dosage</topic><topic>Timolol - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Keates, Edwin U.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Keates, Edwin U.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of Timolol Maleate Combination Therapy in Chronic Open-Angle Glaucoma</atitle><jtitle>American journal of ophthalmology</jtitle><addtitle>Am J Ophthalmol</addtitle><date>1979-09</date><risdate>1979</risdate><volume>88</volume><issue>3</issue><spage>565</spage><epage>571</epage><pages>565-571</pages><issn>0002-9394</issn><eissn>1879-1891</eissn><abstract>In an eight-week study, timolol maleate ophthalmic solution 0.25% was administered twice daily with either pilocarpine 2% four times a day, epinephrine 2% twice a day, carbachol 1.5% four times a day, or 250 mg of acetazolamide twice a day to 44 patients with chronic open-angle glaucoma. Compared to baseline readings on standard therapy alone, mean intraocular pressure was significantly reduced after addition of timolol maleate to each of the regimens. Mean facility of outflow was unaffected. No clinically significant ocular irritation or changes in visual acuity, pupil size, or vital signs were observed in any patient. Timolol maleate appears to be effective and well tolerated when administered with other antiglaucoma medications in patients with open-angle glaucoma.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>484687</pmid><doi>10.1016/0002-9394(79)90516-6</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9394 |
| ispartof | American journal of ophthalmology, 1979-09, Vol.88 (3), p.565-571 |
| issn | 0002-9394 1879-1891 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74732709 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acetazolamide - administration & dosage Adult Aged Carbachol - administration & dosage Drug Therapy, Combination Epinephrine - administration & dosage Female Glaucoma - drug therapy Glaucoma - physiopathology Humans Intraocular Pressure Male Middle Aged Pilocarpine - administration & dosage Propanolamines - administration & dosage Timolol - administration & dosage |
| title | Evaluation of Timolol Maleate Combination Therapy in Chronic Open-Angle Glaucoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T22%3A05%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evaluation%20of%20Timolol%20Maleate%20Combination%20Therapy%20in%20Chronic%20Open-Angle%20Glaucoma&rft.jtitle=American%20journal%20of%20ophthalmology&rft.au=Keates,%20Edwin%20U.&rft.date=1979-09&rft.volume=88&rft.issue=3&rft.spage=565&rft.epage=571&rft.pages=565-571&rft.issn=0002-9394&rft.eissn=1879-1891&rft_id=info:doi/10.1016/0002-9394(79)90516-6&rft_dat=%3Cproquest_cross%3E74732709%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=74732709&rft_id=info:pmid/484687&rft_els_id=0002939479905166&rfr_iscdi=true |