Tumor uptake of radiolabeled pyrimidine bases and pyrimidine nucleosides in animal models —II. 6-[3H]-5-fluoro-2′-deoxyuridine
The short-term differential distribution of 6-[ 3H]-5-fluoro-2′-deoxyuridine (6-[ 3H]-5-FUdR) has been studied in vivo in the Ehrlich Ascites carcinoma (EACa) and Lewis Lung carcinoma (LLCa) tumor models in mice. Significant uptake of the nucleoside by the spleen, bone marrow, gastrointestinal tract...
Gespeichert in:
| Veröffentlicht in: | International journal of nuclear medicine & biology 1979, Vol.6 (2), p.103-107 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 107 |
|---|---|
| container_issue | 2 |
| container_start_page | 103 |
| container_title | International journal of nuclear medicine & biology |
| container_volume | 6 |
| creator | Abrams, D.N. Knaus, E.E. Lentle, B.C. Wiebe, L.I. |
| description | The short-term differential distribution of 6-[
3H]-5-fluoro-2′-deoxyuridine (6-[
3H]-5-FUdR) has been studied
in vivo in the Ehrlich Ascites carcinoma (EACa) and Lewis Lung carcinoma (LLCa) tumor models in mice. Significant uptake of the nucleoside by the spleen, bone marrow, gastrointestinal tract and liver were observed, along with tumor:blood ratios of radioactivity in the region of 50:1. The maximum uptake of 6-[
3H]-5-FUdR by the EACa and LLCa tumors represented 4.3% and 5.3% of the dose respectively. Approximately 60% of the administered dose was excreted in the urine within 6 h, and 80% of the dose was present in 72 h urine. Analysis of excretion data indicated that the fast elimination component half-times were 3.8 h (EACa) and 1.1 h (LLCa). Respective slow component half-times were 49 and 80 h. |
| doi_str_mv | 10.1016/0047-0740(79)90004-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_74729015</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0047074079900044</els_id><sourcerecordid>74729015</sourcerecordid><originalsourceid>FETCH-LOGICAL-c271t-af6cac90817188051c36ab8c80e0cfbd985ce4a689fa68a437db6c584ad1c153</originalsourceid><addsrcrecordid>eNp9kDtOAzEQhl3wftyAwhWCwmAn3rXdIKGIRyQkmnQIWV57VjJ418HOItIhzsBJOBInYZMgEA3NjOb_Z35pPoQOGD1hlJWnlHJBqOD0SKhjRfuR8DW0_SNvoZ2cHygdSF6Um2iDFUIpuY3eJl0TE-6mM_MIONY4GedjMBUEcHg6T77xzreAK5MhY9P-EdvOBojZu97ybe_6xgTcRAch48_X9_H4BJfkbnh9TwpShy6mSAafrx_EQXyZd2mZsofWaxMy7H_3XTS5vJiMrsnN7dV4dH5D7ECwGTF1aY1VVDLBpKQFs8PSVNJKCtTWlVOysMBNKVXdF8OHwlWlLSQ3jllWDHfR4Sp2muJTB3mmG58thGBaiF3WgouBostFvlq0KeacoNbT_mGT5ppRvYCtF1T1gqoWSi9ha96fHXznd1UD7vdoSbq3z1Z2jwaePSSdrYfWgvMJ7Ey76P_P_wKQKpNn</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>74729015</pqid></control><display><type>article</type><title>Tumor uptake of radiolabeled pyrimidine bases and pyrimidine nucleosides in animal models —II. 6-[3H]-5-fluoro-2′-deoxyuridine</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Abrams, D.N. ; Knaus, E.E. ; Lentle, B.C. ; Wiebe, L.I.</creator><creatorcontrib>Abrams, D.N. ; Knaus, E.E. ; Lentle, B.C. ; Wiebe, L.I.</creatorcontrib><description>The short-term differential distribution of 6-[
3H]-5-fluoro-2′-deoxyuridine (6-[
3H]-5-FUdR) has been studied
in vivo in the Ehrlich Ascites carcinoma (EACa) and Lewis Lung carcinoma (LLCa) tumor models in mice. Significant uptake of the nucleoside by the spleen, bone marrow, gastrointestinal tract and liver were observed, along with tumor:blood ratios of radioactivity in the region of 50:1. The maximum uptake of 6-[
3H]-5-FUdR by the EACa and LLCa tumors represented 4.3% and 5.3% of the dose respectively. Approximately 60% of the administered dose was excreted in the urine within 6 h, and 80% of the dose was present in 72 h urine. Analysis of excretion data indicated that the fast elimination component half-times were 3.8 h (EACa) and 1.1 h (LLCa). Respective slow component half-times were 49 and 80 h.</description><identifier>ISSN: 0047-0740</identifier><identifier>DOI: 10.1016/0047-0740(79)90004-4</identifier><identifier>PMID: 157998</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Carcinoma, Ehrlich Tumor - metabolism ; Carcinoma, Ehrlich Tumor - urine ; Floxuridine - metabolism ; Floxuridine - urine ; Half-Life ; Lung Neoplasms - metabolism ; Lung Neoplasms - urine ; Male ; Mice ; Neoplasm Transplantation ; Neoplasms, Experimental - metabolism ; Neoplasms, Experimental - urine ; Pyrimidine Nucleosides - metabolism ; Pyrimidine Nucleosides - urine ; Time Factors ; Tritium</subject><ispartof>International journal of nuclear medicine & biology, 1979, Vol.6 (2), p.103-107</ispartof><rights>1979</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c271t-af6cac90817188051c36ab8c80e0cfbd985ce4a689fa68a437db6c584ad1c153</citedby><cites>FETCH-LOGICAL-c271t-af6cac90817188051c36ab8c80e0cfbd985ce4a689fa68a437db6c584ad1c153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/157998$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abrams, D.N.</creatorcontrib><creatorcontrib>Knaus, E.E.</creatorcontrib><creatorcontrib>Lentle, B.C.</creatorcontrib><creatorcontrib>Wiebe, L.I.</creatorcontrib><title>Tumor uptake of radiolabeled pyrimidine bases and pyrimidine nucleosides in animal models —II. 6-[3H]-5-fluoro-2′-deoxyuridine</title><title>International journal of nuclear medicine & biology</title><addtitle>Int J Nucl Med Biol</addtitle><description>The short-term differential distribution of 6-[
3H]-5-fluoro-2′-deoxyuridine (6-[
3H]-5-FUdR) has been studied
in vivo in the Ehrlich Ascites carcinoma (EACa) and Lewis Lung carcinoma (LLCa) tumor models in mice. Significant uptake of the nucleoside by the spleen, bone marrow, gastrointestinal tract and liver were observed, along with tumor:blood ratios of radioactivity in the region of 50:1. The maximum uptake of 6-[
3H]-5-FUdR by the EACa and LLCa tumors represented 4.3% and 5.3% of the dose respectively. Approximately 60% of the administered dose was excreted in the urine within 6 h, and 80% of the dose was present in 72 h urine. Analysis of excretion data indicated that the fast elimination component half-times were 3.8 h (EACa) and 1.1 h (LLCa). Respective slow component half-times were 49 and 80 h.</description><subject>Animals</subject><subject>Carcinoma, Ehrlich Tumor - metabolism</subject><subject>Carcinoma, Ehrlich Tumor - urine</subject><subject>Floxuridine - metabolism</subject><subject>Floxuridine - urine</subject><subject>Half-Life</subject><subject>Lung Neoplasms - metabolism</subject><subject>Lung Neoplasms - urine</subject><subject>Male</subject><subject>Mice</subject><subject>Neoplasm Transplantation</subject><subject>Neoplasms, Experimental - metabolism</subject><subject>Neoplasms, Experimental - urine</subject><subject>Pyrimidine Nucleosides - metabolism</subject><subject>Pyrimidine Nucleosides - urine</subject><subject>Time Factors</subject><subject>Tritium</subject><issn>0047-0740</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kDtOAzEQhl3wftyAwhWCwmAn3rXdIKGIRyQkmnQIWV57VjJ418HOItIhzsBJOBInYZMgEA3NjOb_Z35pPoQOGD1hlJWnlHJBqOD0SKhjRfuR8DW0_SNvoZ2cHygdSF6Um2iDFUIpuY3eJl0TE-6mM_MIONY4GedjMBUEcHg6T77xzreAK5MhY9P-EdvOBojZu97ybe_6xgTcRAch48_X9_H4BJfkbnh9TwpShy6mSAafrx_EQXyZd2mZsofWaxMy7H_3XTS5vJiMrsnN7dV4dH5D7ECwGTF1aY1VVDLBpKQFs8PSVNJKCtTWlVOysMBNKVXdF8OHwlWlLSQ3jllWDHfR4Sp2muJTB3mmG58thGBaiF3WgouBostFvlq0KeacoNbT_mGT5ppRvYCtF1T1gqoWSi9ha96fHXznd1UD7vdoSbq3z1Z2jwaePSSdrYfWgvMJ7Ey76P_P_wKQKpNn</recordid><startdate>1979</startdate><enddate>1979</enddate><creator>Abrams, D.N.</creator><creator>Knaus, E.E.</creator><creator>Lentle, B.C.</creator><creator>Wiebe, L.I.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1979</creationdate><title>Tumor uptake of radiolabeled pyrimidine bases and pyrimidine nucleosides in animal models —II. 6-[3H]-5-fluoro-2′-deoxyuridine</title><author>Abrams, D.N. ; Knaus, E.E. ; Lentle, B.C. ; Wiebe, L.I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c271t-af6cac90817188051c36ab8c80e0cfbd985ce4a689fa68a437db6c584ad1c153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Animals</topic><topic>Carcinoma, Ehrlich Tumor - metabolism</topic><topic>Carcinoma, Ehrlich Tumor - urine</topic><topic>Floxuridine - metabolism</topic><topic>Floxuridine - urine</topic><topic>Half-Life</topic><topic>Lung Neoplasms - metabolism</topic><topic>Lung Neoplasms - urine</topic><topic>Male</topic><topic>Mice</topic><topic>Neoplasm Transplantation</topic><topic>Neoplasms, Experimental - metabolism</topic><topic>Neoplasms, Experimental - urine</topic><topic>Pyrimidine Nucleosides - metabolism</topic><topic>Pyrimidine Nucleosides - urine</topic><topic>Time Factors</topic><topic>Tritium</topic><toplevel>online_resources</toplevel><creatorcontrib>Abrams, D.N.</creatorcontrib><creatorcontrib>Knaus, E.E.</creatorcontrib><creatorcontrib>Lentle, B.C.</creatorcontrib><creatorcontrib>Wiebe, L.I.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of nuclear medicine & biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abrams, D.N.</au><au>Knaus, E.E.</au><au>Lentle, B.C.</au><au>Wiebe, L.I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tumor uptake of radiolabeled pyrimidine bases and pyrimidine nucleosides in animal models —II. 6-[3H]-5-fluoro-2′-deoxyuridine</atitle><jtitle>International journal of nuclear medicine & biology</jtitle><addtitle>Int J Nucl Med Biol</addtitle><date>1979</date><risdate>1979</risdate><volume>6</volume><issue>2</issue><spage>103</spage><epage>107</epage><pages>103-107</pages><issn>0047-0740</issn><abstract>The short-term differential distribution of 6-[
3H]-5-fluoro-2′-deoxyuridine (6-[
3H]-5-FUdR) has been studied
in vivo in the Ehrlich Ascites carcinoma (EACa) and Lewis Lung carcinoma (LLCa) tumor models in mice. Significant uptake of the nucleoside by the spleen, bone marrow, gastrointestinal tract and liver were observed, along with tumor:blood ratios of radioactivity in the region of 50:1. The maximum uptake of 6-[
3H]-5-FUdR by the EACa and LLCa tumors represented 4.3% and 5.3% of the dose respectively. Approximately 60% of the administered dose was excreted in the urine within 6 h, and 80% of the dose was present in 72 h urine. Analysis of excretion data indicated that the fast elimination component half-times were 3.8 h (EACa) and 1.1 h (LLCa). Respective slow component half-times were 49 and 80 h.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>157998</pmid><doi>10.1016/0047-0740(79)90004-4</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0047-0740 |
| ispartof | International journal of nuclear medicine & biology, 1979, Vol.6 (2), p.103-107 |
| issn | 0047-0740 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74729015 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Carcinoma, Ehrlich Tumor - metabolism Carcinoma, Ehrlich Tumor - urine Floxuridine - metabolism Floxuridine - urine Half-Life Lung Neoplasms - metabolism Lung Neoplasms - urine Male Mice Neoplasm Transplantation Neoplasms, Experimental - metabolism Neoplasms, Experimental - urine Pyrimidine Nucleosides - metabolism Pyrimidine Nucleosides - urine Time Factors Tritium |
| title | Tumor uptake of radiolabeled pyrimidine bases and pyrimidine nucleosides in animal models —II. 6-[3H]-5-fluoro-2′-deoxyuridine |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T13%3A15%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Tumor%20uptake%20of%20radiolabeled%20pyrimidine%20bases%20and%20pyrimidine%20nucleosides%20in%20animal%20models%20%E2%80%94II.%206-%5B3H%5D-5-fluoro-2%E2%80%B2-deoxyuridine&rft.jtitle=International%20journal%20of%20nuclear%20medicine%20&%20biology&rft.au=Abrams,%20D.N.&rft.date=1979&rft.volume=6&rft.issue=2&rft.spage=103&rft.epage=107&rft.pages=103-107&rft.issn=0047-0740&rft_id=info:doi/10.1016/0047-0740(79)90004-4&rft_dat=%3Cproquest_cross%3E74729015%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=74729015&rft_id=info:pmid/157998&rft_els_id=0047074079900044&rfr_iscdi=true |