Impaired acid neutralization in the duodenum in pancreatic insufficiency
The influence of severe exocrine pancreatic disease on the acid-neutralizing capacity of the duodenum was studied in five patients with pancreatic insufficiency (PI) and six control subjects using duodenal perfusion-marker technique. Hydrochloric acid (0.1 N containing 1% PEG) was infused at constan...
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| Veröffentlicht in: | Digestive diseases and sciences 1979-10, Vol.24 (10), p.775-780 |
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| creator | Dutta, S K Russell, R M Iber, F L |
| description | The influence of severe exocrine pancreatic disease on the acid-neutralizing capacity of the duodenum was studied in five patients with pancreatic insufficiency (PI) and six control subjects using duodenal perfusion-marker technique. Hydrochloric acid (0.1 N containing 1% PEG) was infused at constant rates (1.2, 4.5 and 7.0 ml/min) into the duodenum just distal to the duodenal bulb. Samples were aspirated from the tip of the duodenal perfusion tube located at the ligament of Treitz. All samples were analyzed for volume, pH, titrable acidity, PEG and [14C]PEG (gastric marker) determination. Patients with PI demonstrated significantly diminished ability to neutralize various acid loads as compared to controls who virtually completely neutralized acid loads in the range of maximal gastric acid secretion. Exogenous secretin did not significantly improve percent acid neutralized in PI. These data clearly indicate that patients with PI have significantly impaired ability to neutralize even small loads of acid in the duodenum. |
| doi_str_mv | 10.1007/BF01317211 |
| format | Article |
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Hydrochloric acid (0.1 N containing 1% PEG) was infused at constant rates (1.2, 4.5 and 7.0 ml/min) into the duodenum just distal to the duodenal bulb. Samples were aspirated from the tip of the duodenal perfusion tube located at the ligament of Treitz. All samples were analyzed for volume, pH, titrable acidity, PEG and [14C]PEG (gastric marker) determination. Patients with PI demonstrated significantly diminished ability to neutralize various acid loads as compared to controls who virtually completely neutralized acid loads in the range of maximal gastric acid secretion. Exogenous secretin did not significantly improve percent acid neutralized in PI. These data clearly indicate that patients with PI have significantly impaired ability to neutralize even small loads of acid in the duodenum.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/BF01317211</identifier><identifier>PMID: 39715</identifier><language>eng</language><publisher>United States</publisher><subject>Bicarbonates - metabolism ; Bicarbonates - pharmacology ; Chronic Disease ; Duodenum - metabolism ; Folic Acid - metabolism ; Gastric Juice - metabolism ; Humans ; Hydrochloric Acid - metabolism ; Hydrogen-Ion Concentration ; Male ; Middle Aged ; Pancreatitis - metabolism ; Polyethylene Glycols - analysis ; Polyethylene Glycols - pharmacology ; Secretory Rate - drug effects</subject><ispartof>Digestive diseases and sciences, 1979-10, Vol.24 (10), p.775-780</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c280t-cd6aa8a9c982588824da908a9906f28237c7037dd9c11d376d2375c91e108bf53</citedby><cites>FETCH-LOGICAL-c280t-cd6aa8a9c982588824da908a9906f28237c7037dd9c11d376d2375c91e108bf53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39715$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dutta, S K</creatorcontrib><creatorcontrib>Russell, R M</creatorcontrib><creatorcontrib>Iber, F L</creatorcontrib><title>Impaired acid neutralization in the duodenum in pancreatic insufficiency</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><description>The influence of severe exocrine pancreatic disease on the acid-neutralizing capacity of the duodenum was studied in five patients with pancreatic insufficiency (PI) and six control subjects using duodenal perfusion-marker technique. Hydrochloric acid (0.1 N containing 1% PEG) was infused at constant rates (1.2, 4.5 and 7.0 ml/min) into the duodenum just distal to the duodenal bulb. Samples were aspirated from the tip of the duodenal perfusion tube located at the ligament of Treitz. All samples were analyzed for volume, pH, titrable acidity, PEG and [14C]PEG (gastric marker) determination. Patients with PI demonstrated significantly diminished ability to neutralize various acid loads as compared to controls who virtually completely neutralized acid loads in the range of maximal gastric acid secretion. Exogenous secretin did not significantly improve percent acid neutralized in PI. These data clearly indicate that patients with PI have significantly impaired ability to neutralize even small loads of acid in the duodenum.</description><subject>Bicarbonates - metabolism</subject><subject>Bicarbonates - pharmacology</subject><subject>Chronic Disease</subject><subject>Duodenum - metabolism</subject><subject>Folic Acid - metabolism</subject><subject>Gastric Juice - metabolism</subject><subject>Humans</subject><subject>Hydrochloric Acid - metabolism</subject><subject>Hydrogen-Ion Concentration</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pancreatitis - metabolism</subject><subject>Polyethylene Glycols - analysis</subject><subject>Polyethylene Glycols - pharmacology</subject><subject>Secretory Rate - drug effects</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkL1PwzAQxS1EBaWwsLJkYkAK3NlNbI9QUVqpEgvMkWs7wihf2PFQ_npcWsH07t799KR7hFwj3CMAf3haAjLkFPGETLHgLKdFKU7JFLBMM2J5Ti5C-AQAybE8IxOWtJiS1bodlPPWZEo7k3U2jl417luNru8y12Xjh81M7I3tYrvfB9Vpb9NZpy3Eunba2U7vLsmkVk2wV0edkffl89tilW9eX9aLx02uqYAx16ZUSiippaCFEILOjZKQDAllTQVlXHNg3BipEQ3jpUlWoSVaBLGtCzYjt4fcwfdf0Yaxal3QtmlUZ_sYKj7nwNPvCbw7gNr3IXhbV4N3rfK7CqHal1b9l5bgm2Nq3LbW_KG_LbEfYMBl3Q</recordid><startdate>197910</startdate><enddate>197910</enddate><creator>Dutta, S K</creator><creator>Russell, R M</creator><creator>Iber, F L</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197910</creationdate><title>Impaired acid neutralization in the duodenum in pancreatic insufficiency</title><author>Dutta, S K ; Russell, R M ; Iber, F L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c280t-cd6aa8a9c982588824da908a9906f28237c7037dd9c11d376d2375c91e108bf53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Bicarbonates - metabolism</topic><topic>Bicarbonates - pharmacology</topic><topic>Chronic Disease</topic><topic>Duodenum - metabolism</topic><topic>Folic Acid - metabolism</topic><topic>Gastric Juice - metabolism</topic><topic>Humans</topic><topic>Hydrochloric Acid - metabolism</topic><topic>Hydrogen-Ion Concentration</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pancreatitis - metabolism</topic><topic>Polyethylene Glycols - analysis</topic><topic>Polyethylene Glycols - pharmacology</topic><topic>Secretory Rate - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dutta, S K</creatorcontrib><creatorcontrib>Russell, R M</creatorcontrib><creatorcontrib>Iber, F L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dutta, S K</au><au>Russell, R M</au><au>Iber, F L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impaired acid neutralization in the duodenum in pancreatic insufficiency</atitle><jtitle>Digestive diseases and sciences</jtitle><addtitle>Dig Dis Sci</addtitle><date>1979-10</date><risdate>1979</risdate><volume>24</volume><issue>10</issue><spage>775</spage><epage>780</epage><pages>775-780</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><abstract>The influence of severe exocrine pancreatic disease on the acid-neutralizing capacity of the duodenum was studied in five patients with pancreatic insufficiency (PI) and six control subjects using duodenal perfusion-marker technique. Hydrochloric acid (0.1 N containing 1% PEG) was infused at constant rates (1.2, 4.5 and 7.0 ml/min) into the duodenum just distal to the duodenal bulb. Samples were aspirated from the tip of the duodenal perfusion tube located at the ligament of Treitz. All samples were analyzed for volume, pH, titrable acidity, PEG and [14C]PEG (gastric marker) determination. Patients with PI demonstrated significantly diminished ability to neutralize various acid loads as compared to controls who virtually completely neutralized acid loads in the range of maximal gastric acid secretion. Exogenous secretin did not significantly improve percent acid neutralized in PI. These data clearly indicate that patients with PI have significantly impaired ability to neutralize even small loads of acid in the duodenum.</abstract><cop>United States</cop><pmid>39715</pmid><doi>10.1007/BF01317211</doi><tpages>6</tpages></addata></record> |
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| ispartof | Digestive diseases and sciences, 1979-10, Vol.24 (10), p.775-780 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Bicarbonates - metabolism Bicarbonates - pharmacology Chronic Disease Duodenum - metabolism Folic Acid - metabolism Gastric Juice - metabolism Humans Hydrochloric Acid - metabolism Hydrogen-Ion Concentration Male Middle Aged Pancreatitis - metabolism Polyethylene Glycols - analysis Polyethylene Glycols - pharmacology Secretory Rate - drug effects |
| title | Impaired acid neutralization in the duodenum in pancreatic insufficiency |
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