Lymphocyte subpopulations in minimal change nephrotic syndrome
Minimal change nephrotic syndrome (MCNS) was characterized by a relative lymphocytopenia, a normal T-cell count, and a discordance between B cells enumerated by the presence of surface immunoglobulins (Bsig) and by C3B receptors (Beac). By either technique of B-cell count, the total number of T and...
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| Veröffentlicht in: | Clinical immunology and immunopathology 1979-09, Vol.14 (1), p.130-136 |
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| container_title | Clinical immunology and immunopathology |
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| creator | Kerpen, Howard O. Bhat, J.Ganesh Kantor, Robert Gauthier, Bernard Rai, Kanti R. Schacht, Robert G. Baldwin, David S. |
| description | Minimal change nephrotic syndrome (MCNS) was characterized by a relative lymphocytopenia, a normal T-cell count, and a discordance between B cells enumerated by the presence of surface immunoglobulins (Bsig) and by C3B receptors (Beac). By either technique of B-cell count, the total number of T and B lymphocytes in MCNS exceeded that of controls, suggesting the presence of “double-marked” cells or decreased null cell population. This alteration in surface receptor characteristics of lymphocytes which was observed both in relapse and in remission, documents an abnormality, in MCNS, possibly of cell-mediated immunity, which may be relevant to its pathogenesis. |
| doi_str_mv | 10.1016/0090-1229(79)90133-8 |
| format | Article |
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By either technique of B-cell count, the total number of T and B lymphocytes in MCNS exceeded that of controls, suggesting the presence of “double-marked” cells or decreased null cell population. This alteration in surface receptor characteristics of lymphocytes which was observed both in relapse and in remission, documents an abnormality, in MCNS, possibly of cell-mediated immunity, which may be relevant to its pathogenesis.</description><identifier>ISSN: 0090-1229</identifier><identifier>EISSN: 1090-2341</identifier><identifier>DOI: 10.1016/0090-1229(79)90133-8</identifier><identifier>PMID: 314370</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; B-Lymphocytes ; Child ; Child, Preschool ; Complement C3 ; Female ; Humans ; Leukocyte Count ; Lymphocytes - classification ; Male ; Nephrotic Syndrome - etiology ; Nephrotic Syndrome - immunology ; Receptors, Complement ; Rosette Formation ; T-Lymphocytes</subject><ispartof>Clinical immunology and immunopathology, 1979-09, Vol.14 (1), p.130-136</ispartof><rights>1979</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c271t-46e8216da5734ece874e18750864c10be238672eb398979beb91b14dd0174eea3</citedby><cites>FETCH-LOGICAL-c271t-46e8216da5734ece874e18750864c10be238672eb398979beb91b14dd0174eea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/314370$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kerpen, Howard O.</creatorcontrib><creatorcontrib>Bhat, J.Ganesh</creatorcontrib><creatorcontrib>Kantor, Robert</creatorcontrib><creatorcontrib>Gauthier, Bernard</creatorcontrib><creatorcontrib>Rai, Kanti R.</creatorcontrib><creatorcontrib>Schacht, Robert G.</creatorcontrib><creatorcontrib>Baldwin, David S.</creatorcontrib><title>Lymphocyte subpopulations in minimal change nephrotic syndrome</title><title>Clinical immunology and immunopathology</title><addtitle>Clin Immunol Immunopathol</addtitle><description>Minimal change nephrotic syndrome (MCNS) was characterized by a relative lymphocytopenia, a normal T-cell count, and a discordance between B cells enumerated by the presence of surface immunoglobulins (Bsig) and by C3B receptors (Beac). By either technique of B-cell count, the total number of T and B lymphocytes in MCNS exceeded that of controls, suggesting the presence of “double-marked” cells or decreased null cell population. This alteration in surface receptor characteristics of lymphocytes which was observed both in relapse and in remission, documents an abnormality, in MCNS, possibly of cell-mediated immunity, which may be relevant to its pathogenesis.</description><subject>Adolescent</subject><subject>Adult</subject><subject>B-Lymphocytes</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Complement C3</subject><subject>Female</subject><subject>Humans</subject><subject>Leukocyte Count</subject><subject>Lymphocytes - classification</subject><subject>Male</subject><subject>Nephrotic Syndrome - etiology</subject><subject>Nephrotic Syndrome - immunology</subject><subject>Receptors, Complement</subject><subject>Rosette Formation</subject><subject>T-Lymphocytes</subject><issn>0090-1229</issn><issn>1090-2341</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtPwzAQhC3EqxT-QQ85ITgEvLEb25dKqOIlVeICZytxttQoiYOdIOXfk5CqRy670s7sSPMRsgB6BxTSe0oVjSFJ1I1Qt4oCY7E8IjMYzwnjcExmB8s5uQjhi1KacirOyCkDzgSdkdWmr5qdM32LUejyxjVdmbXW1SGydVTZ2lZZGZldVn9iVGOz8661Jgp9XXhX4SU52WZlwKv9npOPp8f39Uu8eXt-XT9sYpMIaGOeokwgLbKlYBwNSsERpFhSmXIDNMeEyVQkmDMllVA55gpy4EVBYXBixubkesptvPvuMLS6ssFgWWY1ui5owQXlwxiMfDIa70LwuNWNHyr4XgPVIzU9ItEjEi2U_qOm5fC22Od3eYXF4WnCNMirScah449Fr4OxWBssrEfT6sLZ__N_AVDbe0s</recordid><startdate>197909</startdate><enddate>197909</enddate><creator>Kerpen, Howard O.</creator><creator>Bhat, J.Ganesh</creator><creator>Kantor, Robert</creator><creator>Gauthier, Bernard</creator><creator>Rai, Kanti R.</creator><creator>Schacht, Robert G.</creator><creator>Baldwin, David S.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197909</creationdate><title>Lymphocyte subpopulations in minimal change nephrotic syndrome</title><author>Kerpen, Howard O. ; Bhat, J.Ganesh ; Kantor, Robert ; Gauthier, Bernard ; Rai, Kanti R. ; Schacht, Robert G. ; Baldwin, David S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c271t-46e8216da5734ece874e18750864c10be238672eb398979beb91b14dd0174eea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>B-Lymphocytes</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Complement C3</topic><topic>Female</topic><topic>Humans</topic><topic>Leukocyte Count</topic><topic>Lymphocytes - classification</topic><topic>Male</topic><topic>Nephrotic Syndrome - etiology</topic><topic>Nephrotic Syndrome - immunology</topic><topic>Receptors, Complement</topic><topic>Rosette Formation</topic><topic>T-Lymphocytes</topic><toplevel>online_resources</toplevel><creatorcontrib>Kerpen, Howard O.</creatorcontrib><creatorcontrib>Bhat, J.Ganesh</creatorcontrib><creatorcontrib>Kantor, Robert</creatorcontrib><creatorcontrib>Gauthier, Bernard</creatorcontrib><creatorcontrib>Rai, Kanti R.</creatorcontrib><creatorcontrib>Schacht, Robert G.</creatorcontrib><creatorcontrib>Baldwin, David S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical immunology and immunopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kerpen, Howard O.</au><au>Bhat, J.Ganesh</au><au>Kantor, Robert</au><au>Gauthier, Bernard</au><au>Rai, Kanti R.</au><au>Schacht, Robert G.</au><au>Baldwin, David S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lymphocyte subpopulations in minimal change nephrotic syndrome</atitle><jtitle>Clinical immunology and immunopathology</jtitle><addtitle>Clin Immunol Immunopathol</addtitle><date>1979-09</date><risdate>1979</risdate><volume>14</volume><issue>1</issue><spage>130</spage><epage>136</epage><pages>130-136</pages><issn>0090-1229</issn><eissn>1090-2341</eissn><abstract>Minimal change nephrotic syndrome (MCNS) was characterized by a relative lymphocytopenia, a normal T-cell count, and a discordance between B cells enumerated by the presence of surface immunoglobulins (Bsig) and by C3B receptors (Beac). 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| ispartof | Clinical immunology and immunopathology, 1979-09, Vol.14 (1), p.130-136 |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adolescent Adult B-Lymphocytes Child Child, Preschool Complement C3 Female Humans Leukocyte Count Lymphocytes - classification Male Nephrotic Syndrome - etiology Nephrotic Syndrome - immunology Receptors, Complement Rosette Formation T-Lymphocytes |
| title | Lymphocyte subpopulations in minimal change nephrotic syndrome |
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