Tumor uptake of radiolabeled pyrimidine bases and pyrimidine nucleosides in animal models—I. 6-[ 3H]-5-fluorouracil
The differential tissue distribution and urinary excretion of small intravenous doses (4 μg kg −1) of 6-[ 3H]-5-fluorouracil have been studied in two strains of mice bearing transplantable tumors. The subcutaneous Lewis Lung carcinoma and the solid Ehrlich Ascites carcinoma both retained less than 1...
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| Veröffentlicht in: | International journal of nuclear medicine & biology 1979, Vol.6 (2), p.97-101 |
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| container_title | International journal of nuclear medicine & biology |
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| creator | Abrams, D.N. Knaus, E.E. Wiebe, L.I. |
| description | The differential tissue distribution and urinary excretion of small intravenous doses (4 μg kg
−1) of 6-[
3H]-5-fluorouracil have been studied in two strains of mice bearing transplantable tumors. The subcutaneous Lewis Lung carcinoma and the solid Ehrlich Ascites carcinoma both retained less than 1.5% of the dose, and for all tissues assayed the tumor: blood ratios for radioactivity were 11:1 or less. Approximately 75% of the injected dose was excreted during the first 12 h. Urinary excretion was resolved using a two-compartmental model. The half-life of the fast component was just over 1 h while that for the slow component was in excess of 10 days. |
| doi_str_mv | 10.1016/0047-0740(79)90003-2 |
| format | Article |
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−1) of 6-[
3H]-5-fluorouracil have been studied in two strains of mice bearing transplantable tumors. The subcutaneous Lewis Lung carcinoma and the solid Ehrlich Ascites carcinoma both retained less than 1.5% of the dose, and for all tissues assayed the tumor: blood ratios for radioactivity were 11:1 or less. Approximately 75% of the injected dose was excreted during the first 12 h. Urinary excretion was resolved using a two-compartmental model. The half-life of the fast component was just over 1 h while that for the slow component was in excess of 10 days.</description><identifier>ISSN: 0047-0740</identifier><identifier>DOI: 10.1016/0047-0740(79)90003-2</identifier><identifier>PMID: 478772</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Carcinoma, Ehrlich Tumor - metabolism ; Carcinoma, Ehrlich Tumor - urine ; Fluorouracil - metabolism ; Fluorouracil - urine ; Half-Life ; Lung Neoplasms - metabolism ; Lung Neoplasms - urine ; Male ; Mice ; Models, Biological ; Neoplasm Transplantation ; Neoplasms, Experimental - metabolism ; Neoplasms, Experimental - urine ; Pyrimidine Nucleosides - metabolism ; Pyrimidine Nucleosides - urine ; Time Factors ; Tritium</subject><ispartof>International journal of nuclear medicine & biology, 1979, Vol.6 (2), p.97-101</ispartof><rights>1979</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c271t-ccd97a6d9ae8f7a3acf99593b5ff96fa45e3e6d3fbf5135ea7705cf6869080a43</citedby><cites>FETCH-LOGICAL-c271t-ccd97a6d9ae8f7a3acf99593b5ff96fa45e3e6d3fbf5135ea7705cf6869080a43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/478772$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abrams, D.N.</creatorcontrib><creatorcontrib>Knaus, E.E.</creatorcontrib><creatorcontrib>Wiebe, L.I.</creatorcontrib><title>Tumor uptake of radiolabeled pyrimidine bases and pyrimidine nucleosides in animal models—I. 6-[ 3H]-5-fluorouracil</title><title>International journal of nuclear medicine & biology</title><addtitle>Int J Nucl Med Biol</addtitle><description>The differential tissue distribution and urinary excretion of small intravenous doses (4 μg kg
−1) of 6-[
3H]-5-fluorouracil have been studied in two strains of mice bearing transplantable tumors. The subcutaneous Lewis Lung carcinoma and the solid Ehrlich Ascites carcinoma both retained less than 1.5% of the dose, and for all tissues assayed the tumor: blood ratios for radioactivity were 11:1 or less. Approximately 75% of the injected dose was excreted during the first 12 h. Urinary excretion was resolved using a two-compartmental model. The half-life of the fast component was just over 1 h while that for the slow component was in excess of 10 days.</description><subject>Animals</subject><subject>Carcinoma, Ehrlich Tumor - metabolism</subject><subject>Carcinoma, Ehrlich Tumor - urine</subject><subject>Fluorouracil - metabolism</subject><subject>Fluorouracil - urine</subject><subject>Half-Life</subject><subject>Lung Neoplasms - metabolism</subject><subject>Lung Neoplasms - urine</subject><subject>Male</subject><subject>Mice</subject><subject>Models, Biological</subject><subject>Neoplasm Transplantation</subject><subject>Neoplasms, Experimental - metabolism</subject><subject>Neoplasms, Experimental - urine</subject><subject>Pyrimidine Nucleosides - metabolism</subject><subject>Pyrimidine Nucleosides - urine</subject><subject>Time Factors</subject><subject>Tritium</subject><issn>0047-0740</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kLlKBTEUhlO4L29gkUq0GM1syaQRRNxAsNFKJJxJTiCamVyTG8HOh_AJfRLnekWwsTrwb3A-QvZKdlSykh8z1oiCiYYdCHkoGWN1Ua2QzV95g2yl9MRY1TUtXydrjeiEqDZJvstDiDTP5vCMNFgawbjgoUePhs7eohuccSPSHhImCuMfcczaY0jOTJYbJ9cN4OkQDPr0-f5xfUR58UDrq8eiLazPIYYcQTu_Q1Yt-IS7P3eb3F-c351dFTe3l9dnpzeFrkQ5L7Q2UgA3ErCzAmrQVspW1n1rreQWmhZr5Ka2vW3LukUQgrXa8o5L1jFo6m2yv9ydxfCSMc3V4JJG72HEkJMSDZeSy2oKNsugjiGliFbNpichvqmSqQVgtSCpFiSVkOobsFrU9n72cz-g-S0t6U72ydKecOCrw6iSdjhqNC6inisT3P_7Xy85jpA</recordid><startdate>1979</startdate><enddate>1979</enddate><creator>Abrams, D.N.</creator><creator>Knaus, E.E.</creator><creator>Wiebe, L.I.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1979</creationdate><title>Tumor uptake of radiolabeled pyrimidine bases and pyrimidine nucleosides in animal models—I. 6-[ 3H]-5-fluorouracil</title><author>Abrams, D.N. ; Knaus, E.E. ; Wiebe, L.I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c271t-ccd97a6d9ae8f7a3acf99593b5ff96fa45e3e6d3fbf5135ea7705cf6869080a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Animals</topic><topic>Carcinoma, Ehrlich Tumor - metabolism</topic><topic>Carcinoma, Ehrlich Tumor - urine</topic><topic>Fluorouracil - metabolism</topic><topic>Fluorouracil - urine</topic><topic>Half-Life</topic><topic>Lung Neoplasms - metabolism</topic><topic>Lung Neoplasms - urine</topic><topic>Male</topic><topic>Mice</topic><topic>Models, Biological</topic><topic>Neoplasm Transplantation</topic><topic>Neoplasms, Experimental - metabolism</topic><topic>Neoplasms, Experimental - urine</topic><topic>Pyrimidine Nucleosides - metabolism</topic><topic>Pyrimidine Nucleosides - urine</topic><topic>Time Factors</topic><topic>Tritium</topic><toplevel>online_resources</toplevel><creatorcontrib>Abrams, D.N.</creatorcontrib><creatorcontrib>Knaus, E.E.</creatorcontrib><creatorcontrib>Wiebe, L.I.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of nuclear medicine & biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abrams, D.N.</au><au>Knaus, E.E.</au><au>Wiebe, L.I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tumor uptake of radiolabeled pyrimidine bases and pyrimidine nucleosides in animal models—I. 6-[ 3H]-5-fluorouracil</atitle><jtitle>International journal of nuclear medicine & biology</jtitle><addtitle>Int J Nucl Med Biol</addtitle><date>1979</date><risdate>1979</risdate><volume>6</volume><issue>2</issue><spage>97</spage><epage>101</epage><pages>97-101</pages><issn>0047-0740</issn><abstract>The differential tissue distribution and urinary excretion of small intravenous doses (4 μg kg
−1) of 6-[
3H]-5-fluorouracil have been studied in two strains of mice bearing transplantable tumors. The subcutaneous Lewis Lung carcinoma and the solid Ehrlich Ascites carcinoma both retained less than 1.5% of the dose, and for all tissues assayed the tumor: blood ratios for radioactivity were 11:1 or less. Approximately 75% of the injected dose was excreted during the first 12 h. Urinary excretion was resolved using a two-compartmental model. The half-life of the fast component was just over 1 h while that for the slow component was in excess of 10 days.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>478772</pmid><doi>10.1016/0047-0740(79)90003-2</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0047-0740 |
| ispartof | International journal of nuclear medicine & biology, 1979, Vol.6 (2), p.97-101 |
| issn | 0047-0740 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74699692 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Carcinoma, Ehrlich Tumor - metabolism Carcinoma, Ehrlich Tumor - urine Fluorouracil - metabolism Fluorouracil - urine Half-Life Lung Neoplasms - metabolism Lung Neoplasms - urine Male Mice Models, Biological Neoplasm Transplantation Neoplasms, Experimental - metabolism Neoplasms, Experimental - urine Pyrimidine Nucleosides - metabolism Pyrimidine Nucleosides - urine Time Factors Tritium |
| title | Tumor uptake of radiolabeled pyrimidine bases and pyrimidine nucleosides in animal models—I. 6-[ 3H]-5-fluorouracil |
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