Longitudinal Study of Tolyl-Reactive IgE Antibodies in Workers Hypersensitive to TDI
Three workers with TDI hypersensitivity were evaluated for IgE antibodies to TDI over a period of 13 months. A radioallergosorbent test (RAST) system was employed using p-tolyl(mono)isocyanate-human serum albumin antigen covalently bound to cyanogen bromide-activated paper discs. IgE antibody titers...
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| Veröffentlicht in: | Journal of occupational medicine 1979-05, Vol.21 (5), p.354-358 |
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| container_title | Journal of occupational medicine |
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| creator | Karol, Meryl H. Sandberg, Theodore Riley, E. Joan Alarie, Yves |
| description | Three workers with TDI hypersensitivity were evaluated for IgE antibodies to TDI over a period of 13 months. A radioallergosorbent test (RAST) system was employed using p-tolyl(mono)isocyanate-human serum albumin antigen covalently bound to cyanogen bromide-activated paper discs. IgE antibody titers were consistently elevated in tw individuals who experienced several bronchial hypersensitivity responses to TDI during the study period. The responses were either solely asthmatic or asthmatic accompanied by cutaneous hypersensitivity reactions. By contrast antibody titers in a third subject who had not experienced any hypersensitivity reactions during the study period continually decreased, falling to insignificant levels after 12 months. In the absence of renewed TDI exposure, sensitive workers may have titers indistinguishable from those of workers exposed to TDI but without sensitivity to the chemical. |
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Joan ; Alarie, Yves</creator><creatorcontrib>Karol, Meryl H. ; Sandberg, Theodore ; Riley, E. Joan ; Alarie, Yves</creatorcontrib><description>Three workers with TDI hypersensitivity were evaluated for IgE antibodies to TDI over a period of 13 months. A radioallergosorbent test (RAST) system was employed using p-tolyl(mono)isocyanate-human serum albumin antigen covalently bound to cyanogen bromide-activated paper discs. IgE antibody titers were consistently elevated in tw individuals who experienced several bronchial hypersensitivity responses to TDI during the study period. The responses were either solely asthmatic or asthmatic accompanied by cutaneous hypersensitivity reactions. By contrast antibody titers in a third subject who had not experienced any hypersensitivity reactions during the study period continually decreased, falling to insignificant levels after 12 months. In the absence of renewed TDI exposure, sensitive workers may have titers indistinguishable from those of workers exposed to TDI but without sensitivity to the chemical.</description><identifier>ISSN: 0096-1736</identifier><identifier>EISSN: 2332-3795</identifier><identifier>PMID: 224155</identifier><language>eng</language><publisher>United States: American Occupational Medical Association</publisher><subject>Adult ; Bronchi - physiopathology ; Cyanates - immunology ; Female ; Humans ; Hypersensitivity - physiopathology ; Hypersensitivity, Immediate - diagnosis ; Immunoglobulin E - analysis ; Male ; Middle Aged ; Original Articles ; Radioallergosorbent Test ; Skin Tests ; Toluene 2,4-Diisocyanate - immunology</subject><ispartof>Journal of occupational medicine, 1979-05, Vol.21 (5), p.354-358</ispartof><rights>Copyrighted American Occupational Medical Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/224155$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karol, Meryl H.</creatorcontrib><creatorcontrib>Sandberg, Theodore</creatorcontrib><creatorcontrib>Riley, E. Joan</creatorcontrib><creatorcontrib>Alarie, Yves</creatorcontrib><title>Longitudinal Study of Tolyl-Reactive IgE Antibodies in Workers Hypersensitive to TDI</title><title>Journal of occupational medicine</title><addtitle>J Occup Med</addtitle><description>Three workers with TDI hypersensitivity were evaluated for IgE antibodies to TDI over a period of 13 months. A radioallergosorbent test (RAST) system was employed using p-tolyl(mono)isocyanate-human serum albumin antigen covalently bound to cyanogen bromide-activated paper discs. IgE antibody titers were consistently elevated in tw individuals who experienced several bronchial hypersensitivity responses to TDI during the study period. The responses were either solely asthmatic or asthmatic accompanied by cutaneous hypersensitivity reactions. By contrast antibody titers in a third subject who had not experienced any hypersensitivity reactions during the study period continually decreased, falling to insignificant levels after 12 months. In the absence of renewed TDI exposure, sensitive workers may have titers indistinguishable from those of workers exposed to TDI but without sensitivity to the chemical.</description><subject>Adult</subject><subject>Bronchi - physiopathology</subject><subject>Cyanates - immunology</subject><subject>Female</subject><subject>Humans</subject><subject>Hypersensitivity - physiopathology</subject><subject>Hypersensitivity, Immediate - diagnosis</subject><subject>Immunoglobulin E - analysis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original Articles</subject><subject>Radioallergosorbent Test</subject><subject>Skin Tests</subject><subject>Toluene 2,4-Diisocyanate - immunology</subject><issn>0096-1736</issn><issn>2332-3795</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kNtKw0AQhhfxVKtvoLBX3gU2s6fsZanVFgqCRrwMOUzL1jRbsxshb-9ii1f_wPfNMPxnZAKcQ8K1kedkwphRSaq5uiY33u8YkxyEuSKXACKVckLyteu2NgyN7cqWvsdhpG5Dc9eObfKGZR3sD9LVdkFnXbCVayx6ajv66fov7D1djocY2Hn7JwZH86fVLbnYlK3Hu1NOycfzIp8vk_Xry2o-Wyc7AB2SOgUjK0i1llynpswqpnl8vgGmUlVBjUKCyLKGs8ZUEpUxgjFhDGYQFwSfksfj3UPvvgf0odhbX2Pblh26wRdaKG0yA1G8P4lDtcemOPR2X_ZjcWwh4ocj3vng-n8qZOxLKc5_Ac09YP4</recordid><startdate>197905</startdate><enddate>197905</enddate><creator>Karol, Meryl H.</creator><creator>Sandberg, Theodore</creator><creator>Riley, E. 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Joan</creatorcontrib><creatorcontrib>Alarie, Yves</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of occupational medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karol, Meryl H.</au><au>Sandberg, Theodore</au><au>Riley, E. Joan</au><au>Alarie, Yves</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longitudinal Study of Tolyl-Reactive IgE Antibodies in Workers Hypersensitive to TDI</atitle><jtitle>Journal of occupational medicine</jtitle><addtitle>J Occup Med</addtitle><date>1979-05</date><risdate>1979</risdate><volume>21</volume><issue>5</issue><spage>354</spage><epage>358</epage><pages>354-358</pages><issn>0096-1736</issn><eissn>2332-3795</eissn><abstract>Three workers with TDI hypersensitivity were evaluated for IgE antibodies to TDI over a period of 13 months. A radioallergosorbent test (RAST) system was employed using p-tolyl(mono)isocyanate-human serum albumin antigen covalently bound to cyanogen bromide-activated paper discs. IgE antibody titers were consistently elevated in tw individuals who experienced several bronchial hypersensitivity responses to TDI during the study period. The responses were either solely asthmatic or asthmatic accompanied by cutaneous hypersensitivity reactions. By contrast antibody titers in a third subject who had not experienced any hypersensitivity reactions during the study period continually decreased, falling to insignificant levels after 12 months. In the absence of renewed TDI exposure, sensitive workers may have titers indistinguishable from those of workers exposed to TDI but without sensitivity to the chemical.</abstract><cop>United States</cop><pub>American Occupational Medical Association</pub><pmid>224155</pmid><tpages>5</tpages></addata></record> |
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| ispartof | Journal of occupational medicine, 1979-05, Vol.21 (5), p.354-358 |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Bronchi - physiopathology Cyanates - immunology Female Humans Hypersensitivity - physiopathology Hypersensitivity, Immediate - diagnosis Immunoglobulin E - analysis Male Middle Aged Original Articles Radioallergosorbent Test Skin Tests Toluene 2,4-Diisocyanate - immunology |
| title | Longitudinal Study of Tolyl-Reactive IgE Antibodies in Workers Hypersensitive to TDI |
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