Ultraviolet-Mediated Cytotoxic Activity of Phenylheptatriyne From Bidens pilosa L
The tropical weed Bidens pilosa L. (Asteraceae) contains a number of polyacetylenes which are phototoxic to bacteria, fungi, and human fibroblast cells in the presence of sunlight, artificial sources of long-wave ultraviolet light, or cool-white fluorescent light. The principle photoactive compound...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 1979, Vol.42 (1), p.103-111 |
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| container_end_page | 111 |
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| container_issue | 1 |
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| container_title | Journal of natural products (Washington, D.C.) |
| container_volume | 42 |
| creator | Wat, Chi-kit Biswas, R. K Graham, E. A Bohm, L Towers, G. H. N Waygood, E. R |
| description | The tropical weed Bidens pilosa L. (Asteraceae) contains a number of polyacetylenes which are phototoxic to bacteria, fungi, and human fibroblast cells in the presence of sunlight, artificial sources of long-wave ultraviolet light, or cool-white fluorescent light. The principle photoactive compound in the leaf, phenylheptatriyne, is present in the cuticle as well as in the underlying cells. Experiments with calf thymus DNA indicate that, unlike photoactive furanocoumarins, phenylheptatriyne does not form interstrand cross linkages with DNA in ultraviolet light. |
| doi_str_mv | 10.1021/np50001a005 |
| format | Article |
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Experiments with calf thymus DNA indicate that, unlike photoactive furanocoumarins, phenylheptatriyne does not form interstrand cross linkages with DNA in ultraviolet light.</description><subject>Alkynes - isolation & purification</subject><subject>Alkynes - metabolism</subject><subject>Alkynes - pharmacology</subject><subject>Animals</subject><subject>Anti-Bacterial Agents</subject><subject>Bacteria - drug effects</subject><subject>Bacteria - radiation effects</subject><subject>Cattle</subject><subject>Cell Survival - drug effects</subject><subject>Cell Survival - radiation effects</subject><subject>DNA - metabolism</subject><subject>Fibroblasts - drug effects</subject><subject>Fibroblasts - radiation effects</subject><subject>Fungi - drug effects</subject><subject>Fungi - radiation effects</subject><subject>Humans</subject><subject>Methoxsalen - pharmacology</subject><subject>Plants - analysis</subject><subject>Ultraviolet Rays</subject><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90Etv1DAUBWAL8RoKK7YIZUUXKHBv_F6WEVNQp6KoHSF1Y3kSh7pk4mB7qubfkypVxQKxuovz6ejqEPIa4QNChR_7gQMAWgD-iCyQV1AKqPhjsgAUtKRKsOfkRUrXk6Kg-TPylAnNOS7I902Xo73xoXO5PHWNt9k1xXLMIYdbXxdHdfY3Po9FaIuzK9eP3ZUbss3Rj70rVjHsik--cX0qBt-FZIv1S_KktV1yr-7vAdmsPl8sv5Trb8dfl0fr0lKtc4lALdOIQgE0daNqiRodo4IJRYWE1m4rbmUtQWmUVAFnW5TMqnbrtFAVPSDv5t4hht97l7LZ-VS7rrO9C_tkJBNTJRUTfD_DOoaUomvNEP3OxtEgmLv9zF_7TfrNfe1-u3PNg50Hm-Jyjn3K7vYhtfGXEZJKbi7Ozs3l6rI6oSen5sfk386-tcHYn9EnszlHrRAkgK7of4BgjPK7hw5nYOtkrsM-9tOq_3z9D-cflwM</recordid><startdate>1979</startdate><enddate>1979</enddate><creator>Wat, Chi-kit</creator><creator>Biswas, R. 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K</creatorcontrib><creatorcontrib>Graham, E. A</creatorcontrib><creatorcontrib>Bohm, L</creatorcontrib><creatorcontrib>Towers, G. H. N</creatorcontrib><creatorcontrib>Waygood, E. R</creatorcontrib><creatorcontrib>FAO, Rome (Italy)</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of natural products (Washington, D.C.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wat, Chi-kit</au><au>Biswas, R. K</au><au>Graham, E. A</au><au>Bohm, L</au><au>Towers, G. H. N</au><au>Waygood, E. R</au><aucorp>FAO, Rome (Italy)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ultraviolet-Mediated Cytotoxic Activity of Phenylheptatriyne From Bidens pilosa L</atitle><jtitle>Journal of natural products (Washington, D.C.)</jtitle><addtitle>J. Nat. Prod</addtitle><date>1979</date><risdate>1979</risdate><volume>42</volume><issue>1</issue><spage>103</spage><epage>111</epage><pages>103-111</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><abstract>The tropical weed Bidens pilosa L. (Asteraceae) contains a number of polyacetylenes which are phototoxic to bacteria, fungi, and human fibroblast cells in the presence of sunlight, artificial sources of long-wave ultraviolet light, or cool-white fluorescent light. The principle photoactive compound in the leaf, phenylheptatriyne, is present in the cuticle as well as in the underlying cells. Experiments with calf thymus DNA indicate that, unlike photoactive furanocoumarins, phenylheptatriyne does not form interstrand cross linkages with DNA in ultraviolet light.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>469551</pmid><doi>10.1021/np50001a005</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0163-3864 |
| ispartof | Journal of natural products (Washington, D.C.), 1979, Vol.42 (1), p.103-111 |
| issn | 0163-3864 1520-6025 |
| language | eng |
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| source | MEDLINE; American Chemical Society (ACS) Journals |
| subjects | Alkynes - isolation & purification Alkynes - metabolism Alkynes - pharmacology Animals Anti-Bacterial Agents Bacteria - drug effects Bacteria - radiation effects Cattle Cell Survival - drug effects Cell Survival - radiation effects DNA - metabolism Fibroblasts - drug effects Fibroblasts - radiation effects Fungi - drug effects Fungi - radiation effects Humans Methoxsalen - pharmacology Plants - analysis Ultraviolet Rays |
| title | Ultraviolet-Mediated Cytotoxic Activity of Phenylheptatriyne From Bidens pilosa L |
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