Sleep induced by L-tryptophan. Effect of dosages within the normal dietary intake
Previous results have demonstrated sleep-inducing effects of L-tryptophan in doses of 1 to 15 g at bedtime. The present laboratory study extends the dose-response curve downward, comparing doses of 1/4 g, 1/2 g, and 1 g of L-tryptophan with placebo, in 15 mild insomniacs (subjects who reported sleep...
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| Veröffentlicht in: | The journal of nervous and mental disease 1979-08, Vol.167 (8), p.497-499 |
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| container_issue | 8 |
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| container_title | The journal of nervous and mental disease |
| container_volume | 167 |
| creator | Hartmann, E Spinweber, C L |
| description | Previous results have demonstrated sleep-inducing effects of L-tryptophan in doses of 1 to 15 g at bedtime. The present laboratory study extends the dose-response curve downward, comparing doses of 1/4 g, 1/2 g, and 1 g of L-tryptophan with placebo, in 15 mild insomniacs (subjects who reported sleep latencies of over 30 minutes). One gram of L-tryptophan significantly reduced sleep latency: the lower doses produced a trend in the same direction. Stage IV sleep was significantly increased by 1/4 g of L-tryptophan. These results at low doses have interesting implications since the normal dietary intake of L-tryptophan is 1/2 g to 2 g per day. |
| doi_str_mv | 10.1097/00005053-197908000-00008 |
| format | Article |
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These results at low doses have interesting implications since the normal dietary intake of L-tryptophan is 1/2 g to 2 g per day.</description><identifier>ISSN: 0022-3018</identifier><identifier>DOI: 10.1097/00005053-197908000-00008</identifier><identifier>PMID: 469515</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Dose-Response Relationship, Drug ; Humans ; Male ; Reaction Time - drug effects ; Sleep - drug effects ; Sleep Initiation and Maintenance Disorders - drug therapy ; Sleep Stages - drug effects ; Tryptophan - therapeutic use</subject><ispartof>The journal of nervous and mental disease, 1979-08, Vol.167 (8), p.497-499</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/469515$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hartmann, E</creatorcontrib><creatorcontrib>Spinweber, C L</creatorcontrib><title>Sleep induced by L-tryptophan. Effect of dosages within the normal dietary intake</title><title>The journal of nervous and mental disease</title><addtitle>J Nerv Ment Dis</addtitle><description>Previous results have demonstrated sleep-inducing effects of L-tryptophan in doses of 1 to 15 g at bedtime. The present laboratory study extends the dose-response curve downward, comparing doses of 1/4 g, 1/2 g, and 1 g of L-tryptophan with placebo, in 15 mild insomniacs (subjects who reported sleep latencies of over 30 minutes). One gram of L-tryptophan significantly reduced sleep latency: the lower doses produced a trend in the same direction. Stage IV sleep was significantly increased by 1/4 g of L-tryptophan. These results at low doses have interesting implications since the normal dietary intake of L-tryptophan is 1/2 g to 2 g per day.</description><subject>Adult</subject><subject>Dose-Response Relationship, Drug</subject><subject>Humans</subject><subject>Male</subject><subject>Reaction Time - drug effects</subject><subject>Sleep - drug effects</subject><subject>Sleep Initiation and Maintenance Disorders - drug therapy</subject><subject>Sleep Stages - drug effects</subject><subject>Tryptophan - therapeutic use</subject><issn>0022-3018</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotUEtPwzAYy4HXGPwDDjlxy_jSJkt6RNN4SJUQAs5Vmnxhhb5oUqH9e4I2XyxblmWZEMphxaFQd5AgQeaMF6oAnRT7t_QJWQBkGcuB6wtyGcIXAFe5gHNyJtaF5HJBXt9axJE2vZstOlrvacnitB_jMO5Mv6Jb79FGOnjqhmA-MdDfJu6ansYd0n6YOtNS12A00z6VRPONV-TUmzbg9ZGX5ONh-755YuXL4_PmvmRjBjIyn0mLYGxec88z5FYrcKgLLzgHLWRtHAqd5nIPRnmDEp0pRGHBOafXPF-S20PvOA0_M4ZYdU2w2Lamx2EOlRJrxdMdKXhzDM51h64ap6ZLc6vDBfkfnvBdpw</recordid><startdate>197908</startdate><enddate>197908</enddate><creator>Hartmann, E</creator><creator>Spinweber, C L</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>197908</creationdate><title>Sleep induced by L-tryptophan. 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These results at low doses have interesting implications since the normal dietary intake of L-tryptophan is 1/2 g to 2 g per day.</abstract><cop>United States</cop><pmid>469515</pmid><doi>10.1097/00005053-197908000-00008</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3018 |
| ispartof | The journal of nervous and mental disease, 1979-08, Vol.167 (8), p.497-499 |
| issn | 0022-3018 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Dose-Response Relationship, Drug Humans Male Reaction Time - drug effects Sleep - drug effects Sleep Initiation and Maintenance Disorders - drug therapy Sleep Stages - drug effects Tryptophan - therapeutic use |
| title | Sleep induced by L-tryptophan. Effect of dosages within the normal dietary intake |
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