A Falling Sphere Method for Studying Clotting in Systems of Purified Blood Components
Summary 1. To study the coagulation of the fibrinogen-thrombin system, a simple rapid method has been developed which measures the time required for the developing coagulum to stop the fall of a plastic bead in a glass tube containing the fibrinogen-thrombin mixture. 2. The “clotting time” thus obta...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1949-05, Vol.71 (1), p.93-96 |
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| container_issue | 1 |
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| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 71 |
| creator | Quinby, William C. Wagley, Philip F. Sizer, Irwin W. |
| description | Summary
1. To study the coagulation of the fibrinogen-thrombin system, a simple rapid method has been developed which measures the time required for the developing coagulum to stop the fall of a plastic bead in a glass tube containing the fibrinogen-thrombin mixture.
2. The “clotting time” thus obtained, increases somewhat with the age of the thrombin and fibrinogen solutions.
3. Kinetic studies of the coagulation process indicate that there is no change in viscosity for a considerable time after the mixing of thrombin and fibrinogen, but that this phase is followed by an abrupt increase in viscosity signifying coagulation of the system.
4. The rate of clotting varies with thrombin concentration in a roughly linear fashion. |
| doi_str_mv | 10.3181/00379727-71-17094 |
| format | Article |
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1. To study the coagulation of the fibrinogen-thrombin system, a simple rapid method has been developed which measures the time required for the developing coagulum to stop the fall of a plastic bead in a glass tube containing the fibrinogen-thrombin mixture.
2. The “clotting time” thus obtained, increases somewhat with the age of the thrombin and fibrinogen solutions.
3. Kinetic studies of the coagulation process indicate that there is no change in viscosity for a considerable time after the mixing of thrombin and fibrinogen, but that this phase is followed by an abrupt increase in viscosity signifying coagulation of the system.
4. The rate of clotting varies with thrombin concentration in a roughly linear fashion.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-71-17094</identifier><identifier>PMID: 18151491</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Accidents ; Blood Coagulation ; Blood Coagulation Tests ; Blood Component Transfusion ; Humans ; Old Medline</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1949-05, Vol.71 (1), p.93-96</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c253t-37381e70919bbb1966ea2e10f775ae6ba334c6f2b13f94bd2d505ccdc2fc79233</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18151491$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Quinby, William C.</creatorcontrib><creatorcontrib>Wagley, Philip F.</creatorcontrib><creatorcontrib>Sizer, Irwin W.</creatorcontrib><title>A Falling Sphere Method for Studying Clotting in Systems of Purified Blood Components</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Summary
1. To study the coagulation of the fibrinogen-thrombin system, a simple rapid method has been developed which measures the time required for the developing coagulum to stop the fall of a plastic bead in a glass tube containing the fibrinogen-thrombin mixture.
2. The “clotting time” thus obtained, increases somewhat with the age of the thrombin and fibrinogen solutions.
3. Kinetic studies of the coagulation process indicate that there is no change in viscosity for a considerable time after the mixing of thrombin and fibrinogen, but that this phase is followed by an abrupt increase in viscosity signifying coagulation of the system.
4. The rate of clotting varies with thrombin concentration in a roughly linear fashion.</description><subject>Accidents</subject><subject>Blood Coagulation</subject><subject>Blood Coagulation Tests</subject><subject>Blood Component Transfusion</subject><subject>Humans</subject><subject>Old Medline</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1949</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1OwzAQhC0EoqXwAFyQT9xSvHEc18dSUUAqAqn0bOVn3aZK4mAnh749CS3ixmlXmm9Gu0PILbAphxk8MMalkqEMJAQgmYrOyBgEFwGPlTon40EPBmBErrzfMwZChvElGfVmAZGCMdnM6TIpy6Le0nWzQ4f0Ddudzamxjq7bLj8M0qK0bTssRU3XB99i5ak19KNzhSkwp4-l7S0LWzW2xrr11-TCJKXHm9OckM3y6XPxEqzen18X81WQhYK3AZd8BtgfDipNU1BxjEmIwIyUIsE4TTiPstiEKXCjojQPc8FEluVZaDKpQs4n5P6Y2zj71aFvdVX4DMsyqdF2XssojrmQsx6EI5g5671DoxtXVIk7aGB66FL_dqkl6J8ue8_dKbxLK8z_HKfyemB6BHyyRb23nav7Z_9J_AZ2aXww</recordid><startdate>194905</startdate><enddate>194905</enddate><creator>Quinby, William C.</creator><creator>Wagley, Philip F.</creator><creator>Sizer, Irwin W.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>194905</creationdate><title>A Falling Sphere Method for Studying Clotting in Systems of Purified Blood Components</title><author>Quinby, William C. ; Wagley, Philip F. ; Sizer, Irwin W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c253t-37381e70919bbb1966ea2e10f775ae6ba334c6f2b13f94bd2d505ccdc2fc79233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1949</creationdate><topic>Accidents</topic><topic>Blood Coagulation</topic><topic>Blood Coagulation Tests</topic><topic>Blood Component Transfusion</topic><topic>Humans</topic><topic>Old Medline</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Quinby, William C.</creatorcontrib><creatorcontrib>Wagley, Philip F.</creatorcontrib><creatorcontrib>Sizer, Irwin W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Quinby, William C.</au><au>Wagley, Philip F.</au><au>Sizer, Irwin W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Falling Sphere Method for Studying Clotting in Systems of Purified Blood Components</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1949-05</date><risdate>1949</risdate><volume>71</volume><issue>1</issue><spage>93</spage><epage>96</epage><pages>93-96</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Summary
1. To study the coagulation of the fibrinogen-thrombin system, a simple rapid method has been developed which measures the time required for the developing coagulum to stop the fall of a plastic bead in a glass tube containing the fibrinogen-thrombin mixture.
2. The “clotting time” thus obtained, increases somewhat with the age of the thrombin and fibrinogen solutions.
3. Kinetic studies of the coagulation process indicate that there is no change in viscosity for a considerable time after the mixing of thrombin and fibrinogen, but that this phase is followed by an abrupt increase in viscosity signifying coagulation of the system.
4. The rate of clotting varies with thrombin concentration in a roughly linear fashion.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>18151491</pmid><doi>10.3181/00379727-71-17094</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0037-9727 |
| ispartof | Experimental biology and medicine (Maywood, N.J.), 1949-05, Vol.71 (1), p.93-96 |
| issn | 0037-9727 1535-3702 1535-3699 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74663578 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Accidents Blood Coagulation Blood Coagulation Tests Blood Component Transfusion Humans Old Medline |
| title | A Falling Sphere Method for Studying Clotting in Systems of Purified Blood Components |
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