Specificity of Lactoferrin as an Inhibitor of Granulocyte-Macrophage Colony-Stimulating Activity Production From Fetal Mouse Liver Cells
Fetal mouse liver cultures capable of producing both erythropoietin (Ep) and granulocyte-macrophage colony stimulating activity (GM-CSA) were used to study the specificity of lactoferrin as an inhibitor of the production of GM-CSA. Both a granulocyte-derived colony-inhibiting activity (CIA) and lact...
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| Veröffentlicht in: | Blood 1979-10, Vol.54 (4), p.951-954 |
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| creator | Zucali, James R Broxmeyer, Hal E Ulatowski, John A |
| description | Fetal mouse liver cultures capable of producing both erythropoietin (Ep) and granulocyte-macrophage colony stimulating activity (GM-CSA) were used to study the specificity of lactoferrin as an inhibitor of the production of GM-CSA. Both a granulocyte-derived colony-inhibiting activity (CIA) and lactoferrin inhibited GM-CSA production while having no effect on Ep production. These results demonstrate the specificity of lactoferrin for GM-CSA production. |
| doi_str_mv | 10.1182/blood.V54.4.951.951 |
| format | Article |
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Both a granulocyte-derived colony-inhibiting activity (CIA) and lactoferrin inhibited GM-CSA production while having no effect on Ep production. These results demonstrate the specificity of lactoferrin for GM-CSA production.</description><identifier>ISSN: 0006-4971</identifier><identifier>EISSN: 1528-0020</identifier><identifier>DOI: 10.1182/blood.V54.4.951.951</identifier><identifier>PMID: 314314</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Colony-Stimulating Factors - biosynthesis ; Erythropoietin - pharmacology ; Female ; Fetus ; Granulocytes - metabolism ; Lactoferrin - pharmacology ; Lactoglobulins - pharmacology ; Leukemia, Myeloid - blood ; Liver - cytology ; Liver - metabolism ; Macrophages - metabolism ; Mice ; Neutrophils - metabolism ; Transferrin - pharmacology</subject><ispartof>Blood, 1979-10, Vol.54 (4), p.951-954</ispartof><rights>1979 American Society of Hematology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-1080015ce8c243a39d4a222948ad7e7d767cef2418f57a9246f54017f7e1525b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/314314$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zucali, James R</creatorcontrib><creatorcontrib>Broxmeyer, Hal E</creatorcontrib><creatorcontrib>Ulatowski, John A</creatorcontrib><title>Specificity of Lactoferrin as an Inhibitor of Granulocyte-Macrophage Colony-Stimulating Activity Production From Fetal Mouse Liver Cells</title><title>Blood</title><addtitle>Blood</addtitle><description>Fetal mouse liver cultures capable of producing both erythropoietin (Ep) and granulocyte-macrophage colony stimulating activity (GM-CSA) were used to study the specificity of lactoferrin as an inhibitor of the production of GM-CSA. Both a granulocyte-derived colony-inhibiting activity (CIA) and lactoferrin inhibited GM-CSA production while having no effect on Ep production. These results demonstrate the specificity of lactoferrin for GM-CSA production.</description><subject>Animals</subject><subject>Colony-Stimulating Factors - biosynthesis</subject><subject>Erythropoietin - pharmacology</subject><subject>Female</subject><subject>Fetus</subject><subject>Granulocytes - metabolism</subject><subject>Lactoferrin - pharmacology</subject><subject>Lactoglobulins - pharmacology</subject><subject>Leukemia, Myeloid - blood</subject><subject>Liver - cytology</subject><subject>Liver - metabolism</subject><subject>Macrophages - metabolism</subject><subject>Mice</subject><subject>Neutrophils - metabolism</subject><subject>Transferrin - pharmacology</subject><issn>0006-4971</issn><issn>1528-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM9O3DAQxi1EgS3wBHDwqbdsbceJkwMHtOoC0qJW4s_V8jpjMErsxXZW2jfoY9dhEcceRvbom_k03w-hC0rmlDbs57r3vps_V3zO521FpzpAM1qxpiCEkUM0I4TUBW8FPUHfY3wjhPKSVcfoqMwfymfo78MGtDVW27TD3uCV0skbCME6rCJWDt-5V7u2yYdJvgnKjb3XuwTFvdLBb17VC-CF773bFQ_JDmOvknUv-Fonu51M_wTfjbnxDi-DH_ASkurxvR8j4JXdQsAL6Pt4hr4Z1Uc4_3xP0dPy1-Pitlj9vrlbXK8KXbZNKihpcohKQ6MZL1XZdlwxxlreqE6A6EQtNBjGaWMqoVrGa1NxQoURkLlU6_IU_dj7boJ_HyEmOdio8wXKQb5JCl7zuuRtHiz3gzlljAGM3AQ7qLCTlMgJv_zALzN-yWVGP1Xeuvy0H9cDdF87e95ZvtrLkCNuLQQZtQWnobMBdJKdt_-1_wfreZiT</recordid><startdate>197910</startdate><enddate>197910</enddate><creator>Zucali, James R</creator><creator>Broxmeyer, Hal E</creator><creator>Ulatowski, John A</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197910</creationdate><title>Specificity of Lactoferrin as an Inhibitor of Granulocyte-Macrophage Colony-Stimulating Activity Production From Fetal Mouse Liver Cells</title><author>Zucali, James R ; Broxmeyer, Hal E ; Ulatowski, John A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-1080015ce8c243a39d4a222948ad7e7d767cef2418f57a9246f54017f7e1525b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Animals</topic><topic>Colony-Stimulating Factors - biosynthesis</topic><topic>Erythropoietin - pharmacology</topic><topic>Female</topic><topic>Fetus</topic><topic>Granulocytes - metabolism</topic><topic>Lactoferrin - pharmacology</topic><topic>Lactoglobulins - pharmacology</topic><topic>Leukemia, Myeloid - blood</topic><topic>Liver - cytology</topic><topic>Liver - metabolism</topic><topic>Macrophages - metabolism</topic><topic>Mice</topic><topic>Neutrophils - metabolism</topic><topic>Transferrin - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zucali, James R</creatorcontrib><creatorcontrib>Broxmeyer, Hal E</creatorcontrib><creatorcontrib>Ulatowski, John A</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zucali, James R</au><au>Broxmeyer, Hal E</au><au>Ulatowski, John A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Specificity of Lactoferrin as an Inhibitor of Granulocyte-Macrophage Colony-Stimulating Activity Production From Fetal Mouse Liver Cells</atitle><jtitle>Blood</jtitle><addtitle>Blood</addtitle><date>1979-10</date><risdate>1979</risdate><volume>54</volume><issue>4</issue><spage>951</spage><epage>954</epage><pages>951-954</pages><issn>0006-4971</issn><eissn>1528-0020</eissn><abstract>Fetal mouse liver cultures capable of producing both erythropoietin (Ep) and granulocyte-macrophage colony stimulating activity (GM-CSA) were used to study the specificity of lactoferrin as an inhibitor of the production of GM-CSA. 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| fulltext | fulltext |
| identifier | ISSN: 0006-4971 |
| ispartof | Blood, 1979-10, Vol.54 (4), p.951-954 |
| issn | 0006-4971 1528-0020 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74646349 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Colony-Stimulating Factors - biosynthesis Erythropoietin - pharmacology Female Fetus Granulocytes - metabolism Lactoferrin - pharmacology Lactoglobulins - pharmacology Leukemia, Myeloid - blood Liver - cytology Liver - metabolism Macrophages - metabolism Mice Neutrophils - metabolism Transferrin - pharmacology |
| title | Specificity of Lactoferrin as an Inhibitor of Granulocyte-Macrophage Colony-Stimulating Activity Production From Fetal Mouse Liver Cells |
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