Desaturation of eicosa‐11,14‐dienoic acid in human testes
The metabolism of [1‐14C]eicosa‐11,14‐dienoic acid was investigated in human testes using whole tissue minces and microsomal preparations. Both types of preparations catalyzed the desaturation of the labeled diene to eicosa‐8,11,14‐trienoic as well as eicosa‐5,11,14‐trienoic acid. The reported resul...
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| Veröffentlicht in: | Lipids 1979-05, Vol.14 (5), p.498-500 |
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| container_title | Lipids |
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| creator | Albert, D. H. Rhamy, R. K. Coniglio, J. G. |
| description | The metabolism of [1‐14C]eicosa‐11,14‐dienoic acid was investigated in human testes using whole tissue minces and microsomal preparations. Both types of preparations catalyzed the desaturation of the labeled diene to eicosa‐8,11,14‐trienoic as well as eicosa‐5,11,14‐trienoic acid. The reported results, therefore, indicate that human testicular tissue, as well as rat testicular tissue (reported previously), is capable of utilizing eicosa‐11,14‐dienoic acid as a precursor of arachidonic acid. Since it is known that there is no Δ8 desaturase activity in rat liver and brain, these studies support the concept that there is a tissue variation in this enzymatic pathway. |
| doi_str_mv | 10.1007/BF02533468 |
| format | Article |
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H. ; Rhamy, R. K. ; Coniglio, J. G.</creator><creatorcontrib>Albert, D. H. ; Rhamy, R. K. ; Coniglio, J. G.</creatorcontrib><description>The metabolism of [1‐14C]eicosa‐11,14‐dienoic acid was investigated in human testes using whole tissue minces and microsomal preparations. Both types of preparations catalyzed the desaturation of the labeled diene to eicosa‐8,11,14‐trienoic as well as eicosa‐5,11,14‐trienoic acid. The reported results, therefore, indicate that human testicular tissue, as well as rat testicular tissue (reported previously), is capable of utilizing eicosa‐11,14‐dienoic acid as a precursor of arachidonic acid. 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H.</creatorcontrib><creatorcontrib>Rhamy, R. K.</creatorcontrib><creatorcontrib>Coniglio, J. G.</creatorcontrib><title>Desaturation of eicosa‐11,14‐dienoic acid in human testes</title><title>Lipids</title><addtitle>Lipids</addtitle><description>The metabolism of [1‐14C]eicosa‐11,14‐dienoic acid was investigated in human testes using whole tissue minces and microsomal preparations. Both types of preparations catalyzed the desaturation of the labeled diene to eicosa‐8,11,14‐trienoic as well as eicosa‐5,11,14‐trienoic acid. The reported results, therefore, indicate that human testicular tissue, as well as rat testicular tissue (reported previously), is capable of utilizing eicosa‐11,14‐dienoic acid as a precursor of arachidonic acid. Since it is known that there is no Δ8 desaturase activity in rat liver and brain, these studies support the concept that there is a tissue variation in this enzymatic pathway.</description><subject>Carbon Radioisotopes</subject><subject>Eicosanoic Acids - metabolism</subject><subject>Humans</subject><subject>Isotope Labeling</subject><subject>Male</subject><subject>Testis - metabolism</subject><issn>0024-4201</issn><issn>1558-9307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAQhi3EVykszAyZGBABO7ZjZ2CAlkKlSjDAbNnOWRjlA-JGqBs_gd_IL8GQCjakk16d7rn3dC9ChwSfEYzF-dUMZ5xSlssNNCKcy7SgWGyiEcYZS1mGyS7aC-E5toQVfAdtM14IwkfoYgpBL_tOL33bJK1LwNs26M_3D0JOCYtaemhabxNtfZn4Jnnqa90kSwix9tGW01WAg7WO0ePs-mFymy7ubuaTy0VqaZbJ1HBDcsYM0YQbUVKeOyat1JBBWWpHMZVCOG4NLQQY58AUYLO4o6UodU7oGB0Pvi9d-9rH06r2wUJV6QbaPijB8vjkD3gygLZrQ-jAqZfO17pbKYLVd1TqL6oIH61de1ND-YsO2cQxHsZvvoLVP0ZqMb-fYlZI-gWOR3Jl</recordid><startdate>197905</startdate><enddate>197905</enddate><creator>Albert, D. 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G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3228-b5b1644b1a15b7d356f48c8ae2eddaf303877f5cb397ebffeb9ec2b16a87da613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Carbon Radioisotopes</topic><topic>Eicosanoic Acids - metabolism</topic><topic>Humans</topic><topic>Isotope Labeling</topic><topic>Male</topic><topic>Testis - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Albert, D. H.</creatorcontrib><creatorcontrib>Rhamy, R. K.</creatorcontrib><creatorcontrib>Coniglio, J. 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| ispartof | Lipids, 1979-05, Vol.14 (5), p.498-500 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Carbon Radioisotopes Eicosanoic Acids - metabolism Humans Isotope Labeling Male Testis - metabolism |
| title | Desaturation of eicosa‐11,14‐dienoic acid in human testes |
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