Niemann-Pick disease [the result of an autosomal recessive genetic mutation] in a Poodle dog
A 5-month-old minature Poodle dog had widespread cytoplasmic vacuolation of neurons in the central nervous system and foamy macrophages in the lung, spleen, renal lymph node, liver, adrenal gland and intestine. Concentric membranous cytoplasmic inclusions were seen in the neurons of the central nerv...
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| Veröffentlicht in: | Veterinary pathology 1979-09, Vol.16 (5), p.530-538 |
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| creator | Bundza, A Lowden, J.A Charlton, K.M |
| description | A 5-month-old minature Poodle dog had widespread cytoplasmic vacuolation of neurons in the central nervous system and foamy macrophages in the lung, spleen, renal lymph node, liver, adrenal gland and intestine. Concentric membranous cytoplasmic inclusions were seen in the neurons of the central nervous system by electron microscopy. There was no sphingomyelinase in the brain tissue. Sphingomyelin and cholesterol were increased in brain, kidney and liver. A diagnosis of Niemann-Pick Disease was based on absence of sphingomyelinase activity, as well as on histologic, histochemical and chemical findings. |
| doi_str_mv | 10.1177/030098587901600504 |
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Concentric membranous cytoplasmic inclusions were seen in the neurons of the central nervous system by electron microscopy. There was no sphingomyelinase in the brain tissue. Sphingomyelin and cholesterol were increased in brain, kidney and liver. A diagnosis of Niemann-Pick Disease was based on absence of sphingomyelinase activity, as well as on histologic, histochemical and chemical findings.</description><identifier>ISSN: 0300-9858</identifier><identifier>EISSN: 1544-2217</identifier><identifier>DOI: 10.1177/030098587901600504</identifier><identifier>PMID: 573013</identifier><language>eng</language><publisher>United States: SAGE Publications</publisher><subject>animal diseases ; animal health ; Animals ; Brain - pathology ; Brain Chemistry ; Dog Diseases - metabolism ; Dog Diseases - pathology ; Dogs ; Female ; Humans ; Liver - pathology ; Niemann-Pick Diseases - metabolism ; Niemann-Pick Diseases - pathology ; Niemann-Pick Diseases - veterinary ; noninfectious diseases ; Sphingomyelins - analysis</subject><ispartof>Veterinary pathology, 1979-09, Vol.16 (5), p.530-538</ispartof><rights>1979 American College of Veterinary Pathologists</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-83d7733f3beef649b4aa83beca93b7a177a02c5972d32aeae272792ff2b05ea73</citedby><cites>FETCH-LOGICAL-c428t-83d7733f3beef649b4aa83beca93b7a177a02c5972d32aeae272792ff2b05ea73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/030098587901600504$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/030098587901600504$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/573013$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bundza, A</creatorcontrib><creatorcontrib>Lowden, J.A</creatorcontrib><creatorcontrib>Charlton, K.M</creatorcontrib><title>Niemann-Pick disease [the result of an autosomal recessive genetic mutation] in a Poodle dog</title><title>Veterinary pathology</title><addtitle>Vet Pathol</addtitle><description>A 5-month-old minature Poodle dog had widespread cytoplasmic vacuolation of neurons in the central nervous system and foamy macrophages in the lung, spleen, renal lymph node, liver, adrenal gland and intestine. Concentric membranous cytoplasmic inclusions were seen in the neurons of the central nervous system by electron microscopy. There was no sphingomyelinase in the brain tissue. Sphingomyelin and cholesterol were increased in brain, kidney and liver. A diagnosis of Niemann-Pick Disease was based on absence of sphingomyelinase activity, as well as on histologic, histochemical and chemical findings.</description><subject>animal diseases</subject><subject>animal health</subject><subject>Animals</subject><subject>Brain - pathology</subject><subject>Brain Chemistry</subject><subject>Dog Diseases - metabolism</subject><subject>Dog Diseases - pathology</subject><subject>Dogs</subject><subject>Female</subject><subject>Humans</subject><subject>Liver - pathology</subject><subject>Niemann-Pick Diseases - metabolism</subject><subject>Niemann-Pick Diseases - pathology</subject><subject>Niemann-Pick Diseases - veterinary</subject><subject>noninfectious diseases</subject><subject>Sphingomyelins - analysis</subject><issn>0300-9858</issn><issn>1544-2217</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9P3DAQxa2Klm63_QIVKj71lu7YTtb2ESH-VEItEnCCypokk8WQxBAnSHx7vArqBYnTaGZ-70nvMfZdwC8htF6BArCmMNqCWAMUkH9gC1HkeSal0DtssQWyLfGZfYnxDkBKa_Qu-1RoBUIt2M0fTx32fXbuq3te-0gYiV-Pt8QHilM78tBw7DlOY4ihwzadK4rRPxHfUE-jr3g3jTj60P_jPoH8PIS6JV6HzVf2scE20rfXuWRXx0eXh6fZ2d-T34cHZ1mVSzNmRtVaK9WokqhZ57bMEU1aKrSq1JiCIsiqsFrWSiIhSS21lU0jSygItVqyn7PvwxAeJ4qj63ysqG2xpzBFp_N1LvS6SKCcwWoIMQ7UuIfBdzg8OwFu26h722gS7b26T2VH9X_JXGF6r-Z3xA25uzANfcr6vuH-rGgwONwMPrqrC5m8QIItjDGJ-PGWENYkvQErtHoBcDqQdw</recordid><startdate>197909</startdate><enddate>197909</enddate><creator>Bundza, A</creator><creator>Lowden, J.A</creator><creator>Charlton, K.M</creator><general>SAGE Publications</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197909</creationdate><title>Niemann-Pick disease [the result of an autosomal recessive genetic mutation] in a Poodle dog</title><author>Bundza, A ; Lowden, J.A ; Charlton, K.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-83d7733f3beef649b4aa83beca93b7a177a02c5972d32aeae272792ff2b05ea73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>animal diseases</topic><topic>animal health</topic><topic>Animals</topic><topic>Brain - pathology</topic><topic>Brain Chemistry</topic><topic>Dog Diseases - metabolism</topic><topic>Dog Diseases - pathology</topic><topic>Dogs</topic><topic>Female</topic><topic>Humans</topic><topic>Liver - pathology</topic><topic>Niemann-Pick Diseases - metabolism</topic><topic>Niemann-Pick Diseases - pathology</topic><topic>Niemann-Pick Diseases - veterinary</topic><topic>noninfectious diseases</topic><topic>Sphingomyelins - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bundza, A</creatorcontrib><creatorcontrib>Lowden, J.A</creatorcontrib><creatorcontrib>Charlton, K.M</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bundza, A</au><au>Lowden, J.A</au><au>Charlton, K.M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Niemann-Pick disease [the result of an autosomal recessive genetic mutation] in a Poodle dog</atitle><jtitle>Veterinary pathology</jtitle><addtitle>Vet Pathol</addtitle><date>1979-09</date><risdate>1979</risdate><volume>16</volume><issue>5</issue><spage>530</spage><epage>538</epage><pages>530-538</pages><issn>0300-9858</issn><eissn>1544-2217</eissn><abstract>A 5-month-old minature Poodle dog had widespread cytoplasmic vacuolation of neurons in the central nervous system and foamy macrophages in the lung, spleen, renal lymph node, liver, adrenal gland and intestine. 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| identifier | ISSN: 0300-9858 |
| ispartof | Veterinary pathology, 1979-09, Vol.16 (5), p.530-538 |
| issn | 0300-9858 1544-2217 |
| language | eng |
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| source | MEDLINE; SAGE Complete A-Z List |
| subjects | animal diseases animal health Animals Brain - pathology Brain Chemistry Dog Diseases - metabolism Dog Diseases - pathology Dogs Female Humans Liver - pathology Niemann-Pick Diseases - metabolism Niemann-Pick Diseases - pathology Niemann-Pick Diseases - veterinary noninfectious diseases Sphingomyelins - analysis |
| title | Niemann-Pick disease [the result of an autosomal recessive genetic mutation] in a Poodle dog |
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