Induction of preterm labor in the rat by antiprogesterone
The validity of a new concept, predicting that preterm labor can be induced without oxytocic stimulation by a regulatory imbalance, generated by antiprogesterone (A-P)-provoked P withdrawal (Pw), has been examined in the rat model. At day 19 of pregnancy a single oral dose of the steroidal A-P isoxa...
Gespeichert in:
| Veröffentlicht in: | American journal of obstetrics and gynecology 1979-08, Vol.134 (7), p.823-827 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 827 |
|---|---|
| container_issue | 7 |
| container_start_page | 823 |
| container_title | American journal of obstetrics and gynecology |
| container_volume | 134 |
| creator | Csapo, Arpad I. Resch, Bela A. |
| description | The validity of a new concept, predicting that preterm labor can be induced without oxytocic stimulation by a regulatory imbalance, generated by antiprogesterone (A-P)-provoked P withdrawal (Pw), has been examined in the rat model. At day 19 of pregnancy a single oral dose of the steroidal A-P isoxazol, which inhibits P synthesis, significantly reduced uterine P levels, increased uterine estradiol and prostaglandin F levels, and induced preterm labor. This precocious regulatory imbalance and preterm labor were prevented, by blocking the A-P-induced Pw with P treatment. The regulatory imbalance which triggered the onset of spontaneous labor in the control animals was similar, but it occurred at term rather than before term. The potential of this method in improving the managernent of medically indicated induction of preterm labor is discussed. (Am. J. Obstet. Gynecol. 134:823, 1979.) |
| doi_str_mv | 10.1016/0002-9378(79)90954-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_74641442</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0002937879909542</els_id><sourcerecordid>74641442</sourcerecordid><originalsourceid>FETCH-LOGICAL-c271t-c3873e0495b73fab8e613966c78f3fbc967664892df28c716b46d84d904c47a83</originalsourceid><addsrcrecordid>eNp9UElLxDAYDeI2jv6DOeQkeqhmmywXQQaXgQEveg5p-lUjXcakFebf29rBo6ePj7fxHkILSm4oofKWEMIyw5W-UubaELMUGTtAM0qMyqSW-hDN_iin6Cylz_Flhp2gYyG50WKGzLopet-FtsFtibcROog1rlzeRhwa3H0Ajq7D-Q67pgvb2L5DGihtA-foqHRVgov9naO3x4fX1XO2eXlar-43mWeKdpnnWnEgwixzxUuXa5CUGym90iUvc2-kklJow4qSaa-ozIUstCgMEV4op_kcXU6-Q_hXP6TbOiQPVeUaaPtklZCCCsEGopiIPrYpRSjtNobaxZ2lxI6D2bG-HdewytjfwewoW-z9-7yG4k80LTTAdxMMQ8fvANEmH6DxUIQIvrNFG_73_wGVKnjJ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>74641442</pqid></control><display><type>article</type><title>Induction of preterm labor in the rat by antiprogesterone</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Csapo, Arpad I. ; Resch, Bela A.</creator><creatorcontrib>Csapo, Arpad I. ; Resch, Bela A.</creatorcontrib><description>The validity of a new concept, predicting that preterm labor can be induced without oxytocic stimulation by a regulatory imbalance, generated by antiprogesterone (A-P)-provoked P withdrawal (Pw), has been examined in the rat model. At day 19 of pregnancy a single oral dose of the steroidal A-P isoxazol, which inhibits P synthesis, significantly reduced uterine P levels, increased uterine estradiol and prostaglandin F levels, and induced preterm labor. This precocious regulatory imbalance and preterm labor were prevented, by blocking the A-P-induced Pw with P treatment. The regulatory imbalance which triggered the onset of spontaneous labor in the control animals was similar, but it occurred at term rather than before term. The potential of this method in improving the managernent of medically indicated induction of preterm labor is discussed. (Am. J. Obstet. Gynecol. 134:823, 1979.)</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/0002-9378(79)90954-2</identifier><identifier>PMID: 463984</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Administration, Oral ; Animals ; Estradiol - analysis ; Female ; Injections, Intramuscular ; Isoxazoles - administration & dosage ; Labor, Induced ; Oxazoles ; Pregnancy ; Progesterone - analysis ; Progesterone - antagonists & inhibitors ; Progesterone Congeners - administration & dosage ; Prostaglandins F - analysis ; Rats ; Uterus - analysis</subject><ispartof>American journal of obstetrics and gynecology, 1979-08, Vol.134 (7), p.823-827</ispartof><rights>1979</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c271t-c3873e0495b73fab8e613966c78f3fbc967664892df28c716b46d84d904c47a83</citedby><cites>FETCH-LOGICAL-c271t-c3873e0495b73fab8e613966c78f3fbc967664892df28c716b46d84d904c47a83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0002937879909542$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/463984$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Csapo, Arpad I.</creatorcontrib><creatorcontrib>Resch, Bela A.</creatorcontrib><title>Induction of preterm labor in the rat by antiprogesterone</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>The validity of a new concept, predicting that preterm labor can be induced without oxytocic stimulation by a regulatory imbalance, generated by antiprogesterone (A-P)-provoked P withdrawal (Pw), has been examined in the rat model. At day 19 of pregnancy a single oral dose of the steroidal A-P isoxazol, which inhibits P synthesis, significantly reduced uterine P levels, increased uterine estradiol and prostaglandin F levels, and induced preterm labor. This precocious regulatory imbalance and preterm labor were prevented, by blocking the A-P-induced Pw with P treatment. The regulatory imbalance which triggered the onset of spontaneous labor in the control animals was similar, but it occurred at term rather than before term. The potential of this method in improving the managernent of medically indicated induction of preterm labor is discussed. (Am. J. Obstet. Gynecol. 134:823, 1979.)</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Estradiol - analysis</subject><subject>Female</subject><subject>Injections, Intramuscular</subject><subject>Isoxazoles - administration & dosage</subject><subject>Labor, Induced</subject><subject>Oxazoles</subject><subject>Pregnancy</subject><subject>Progesterone - analysis</subject><subject>Progesterone - antagonists & inhibitors</subject><subject>Progesterone Congeners - administration & dosage</subject><subject>Prostaglandins F - analysis</subject><subject>Rats</subject><subject>Uterus - analysis</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UElLxDAYDeI2jv6DOeQkeqhmmywXQQaXgQEveg5p-lUjXcakFebf29rBo6ePj7fxHkILSm4oofKWEMIyw5W-UubaELMUGTtAM0qMyqSW-hDN_iin6Cylz_Flhp2gYyG50WKGzLopet-FtsFtibcROog1rlzeRhwa3H0Ajq7D-Q67pgvb2L5DGihtA-foqHRVgov9naO3x4fX1XO2eXlar-43mWeKdpnnWnEgwixzxUuXa5CUGym90iUvc2-kklJow4qSaa-ozIUstCgMEV4op_kcXU6-Q_hXP6TbOiQPVeUaaPtklZCCCsEGopiIPrYpRSjtNobaxZ2lxI6D2bG-HdewytjfwewoW-z9-7yG4k80LTTAdxMMQ8fvANEmH6DxUIQIvrNFG_73_wGVKnjJ</recordid><startdate>19790801</startdate><enddate>19790801</enddate><creator>Csapo, Arpad I.</creator><creator>Resch, Bela A.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19790801</creationdate><title>Induction of preterm labor in the rat by antiprogesterone</title><author>Csapo, Arpad I. ; Resch, Bela A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c271t-c3873e0495b73fab8e613966c78f3fbc967664892df28c716b46d84d904c47a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Estradiol - analysis</topic><topic>Female</topic><topic>Injections, Intramuscular</topic><topic>Isoxazoles - administration & dosage</topic><topic>Labor, Induced</topic><topic>Oxazoles</topic><topic>Pregnancy</topic><topic>Progesterone - analysis</topic><topic>Progesterone - antagonists & inhibitors</topic><topic>Progesterone Congeners - administration & dosage</topic><topic>Prostaglandins F - analysis</topic><topic>Rats</topic><topic>Uterus - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Csapo, Arpad I.</creatorcontrib><creatorcontrib>Resch, Bela A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Csapo, Arpad I.</au><au>Resch, Bela A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Induction of preterm labor in the rat by antiprogesterone</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>1979-08-01</date><risdate>1979</risdate><volume>134</volume><issue>7</issue><spage>823</spage><epage>827</epage><pages>823-827</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><abstract>The validity of a new concept, predicting that preterm labor can be induced without oxytocic stimulation by a regulatory imbalance, generated by antiprogesterone (A-P)-provoked P withdrawal (Pw), has been examined in the rat model. At day 19 of pregnancy a single oral dose of the steroidal A-P isoxazol, which inhibits P synthesis, significantly reduced uterine P levels, increased uterine estradiol and prostaglandin F levels, and induced preterm labor. This precocious regulatory imbalance and preterm labor were prevented, by blocking the A-P-induced Pw with P treatment. The regulatory imbalance which triggered the onset of spontaneous labor in the control animals was similar, but it occurred at term rather than before term. The potential of this method in improving the managernent of medically indicated induction of preterm labor is discussed. (Am. J. Obstet. Gynecol. 134:823, 1979.)</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>463984</pmid><doi>10.1016/0002-9378(79)90954-2</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9378 |
| ispartof | American journal of obstetrics and gynecology, 1979-08, Vol.134 (7), p.823-827 |
| issn | 0002-9378 1097-6868 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74641442 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Administration, Oral Animals Estradiol - analysis Female Injections, Intramuscular Isoxazoles - administration & dosage Labor, Induced Oxazoles Pregnancy Progesterone - analysis Progesterone - antagonists & inhibitors Progesterone Congeners - administration & dosage Prostaglandins F - analysis Rats Uterus - analysis |
| title | Induction of preterm labor in the rat by antiprogesterone |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T21%3A33%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Induction%20of%20preterm%20labor%20in%20the%20rat%20by%20antiprogesterone&rft.jtitle=American%20journal%20of%20obstetrics%20and%20gynecology&rft.au=Csapo,%20Arpad%20I.&rft.date=1979-08-01&rft.volume=134&rft.issue=7&rft.spage=823&rft.epage=827&rft.pages=823-827&rft.issn=0002-9378&rft.eissn=1097-6868&rft_id=info:doi/10.1016/0002-9378(79)90954-2&rft_dat=%3Cproquest_cross%3E74641442%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=74641442&rft_id=info:pmid/463984&rft_els_id=0002937879909542&rfr_iscdi=true |