Parenteral prophylaxis against enterococcal endocarditis
Three commonly used antibiotic regimens for the prevention of enterococcal endocarditis were administered parenterally to six healthy men in a crossover manner. The regimens included 1 gm of streptomycin intramuscularly (IM) in combination with (1) procaine penicillin 600,000 units plus aqueous peni...
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| Veröffentlicht in: | The American journal of the medical sciences 1979-03, Vol.277 (2), p.195-200 |
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| container_title | The American journal of the medical sciences |
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| creator | Murillo, J Standiford, H C Tatem, B A Caplan, E S Calia, F M |
| description | Three commonly used antibiotic regimens for the prevention of enterococcal endocarditis were administered parenterally to six healthy men in a crossover manner. The regimens included 1 gm of streptomycin intramuscularly (IM) in combination with (1) procaine penicillin 600,000 units plus aqueous penicillin G 200,000 units IM; or (2) ampicillin 25 mg/kg intravenously (IV); or (3) ampicillin 1 gm IM. The combinations containing ampicillin IM or IV with streptomycin produced bactericidal activity at dilutions of 1:2 or greater for the majority of the strains, whereas the penicillin-streptomycin regimen did not. All regimens were poorly bactericidal against three strains of enterococci which were highly resistant to streptomycin. These data suggest that ampicillin plus streptomycin is the preferred regimen for prophylaxis. |
| doi_str_mv | 10.1097/00000441-197903000-00008 |
| format | Article |
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The regimens included 1 gm of streptomycin intramuscularly (IM) in combination with (1) procaine penicillin 600,000 units plus aqueous penicillin G 200,000 units IM; or (2) ampicillin 25 mg/kg intravenously (IV); or (3) ampicillin 1 gm IM. The combinations containing ampicillin IM or IV with streptomycin produced bactericidal activity at dilutions of 1:2 or greater for the majority of the strains, whereas the penicillin-streptomycin regimen did not. All regimens were poorly bactericidal against three strains of enterococci which were highly resistant to streptomycin. These data suggest that ampicillin plus streptomycin is the preferred regimen for prophylaxis.</description><identifier>ISSN: 0002-9629</identifier><identifier>DOI: 10.1097/00000441-197903000-00008</identifier><identifier>PMID: 463947</identifier><language>eng</language><publisher>United States</publisher><subject><![CDATA[Ampicillin - administration & dosage ; Ampicillin - therapeutic use ; Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - blood ; Anti-Bacterial Agents - therapeutic use ; Endocarditis, Bacterial - prevention & control ; Enterobacteriaceae Infections - prevention & control ; Humans ; Infusions, Parenteral ; Injections, Intramuscular ; Male ; Penicillin G - administration & dosage ; Penicillin G - therapeutic use ; Penicillin G Procaine - administration & dosage ; Penicillin G Procaine - therapeutic use ; Streptomycin - administration & dosage ; Streptomycin - therapeutic use]]></subject><ispartof>The American journal of the medical sciences, 1979-03, Vol.277 (2), p.195-200</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c309t-c2a45fab65723a7ab9c9fbe3373d51529fb040b04ed846cb61c68e20be69643</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/463947$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Murillo, J</creatorcontrib><creatorcontrib>Standiford, H C</creatorcontrib><creatorcontrib>Tatem, B A</creatorcontrib><creatorcontrib>Caplan, E S</creatorcontrib><creatorcontrib>Calia, F M</creatorcontrib><title>Parenteral prophylaxis against enterococcal endocarditis</title><title>The American journal of the medical sciences</title><addtitle>Am J Med Sci</addtitle><description>Three commonly used antibiotic regimens for the prevention of enterococcal endocarditis were administered parenterally to six healthy men in a crossover manner. The regimens included 1 gm of streptomycin intramuscularly (IM) in combination with (1) procaine penicillin 600,000 units plus aqueous penicillin G 200,000 units IM; or (2) ampicillin 25 mg/kg intravenously (IV); or (3) ampicillin 1 gm IM. The combinations containing ampicillin IM or IV with streptomycin produced bactericidal activity at dilutions of 1:2 or greater for the majority of the strains, whereas the penicillin-streptomycin regimen did not. All regimens were poorly bactericidal against three strains of enterococci which were highly resistant to streptomycin. These data suggest that ampicillin plus streptomycin is the preferred regimen for prophylaxis.</description><subject>Ampicillin - administration & dosage</subject><subject>Ampicillin - therapeutic use</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - blood</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Endocarditis, Bacterial - prevention & control</subject><subject>Enterobacteriaceae Infections - prevention & control</subject><subject>Humans</subject><subject>Infusions, Parenteral</subject><subject>Injections, Intramuscular</subject><subject>Male</subject><subject>Penicillin G - administration & dosage</subject><subject>Penicillin G - therapeutic use</subject><subject>Penicillin G Procaine - administration & dosage</subject><subject>Penicillin G Procaine - therapeutic use</subject><subject>Streptomycin - administration & dosage</subject><subject>Streptomycin - therapeutic use</subject><issn>0002-9629</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UMlOw0AMnQNbKfwBh5y4BWbLLEdUQUGqBBLcR87EgaAsZSaV6N8zaUstWdaz37OtR0jG6B2jVt_TKaRkObPaUpFAPnXMCZmlwnOruL0glzF-U8q4YeKcnEklrNQzYt4gYD9igDZbh2H9tW3ht4kZfELTxzHbzQY_eJ8I2FeDh1A1YxOvyGkNbcTrQ52T96fHj8VzvnpdviweVrkX1I655yCLGkpVaC5AQ2m9rUsUQouqYAVPgEqaEisjlS8V88ogpyUqq6SYk9v91vTbzwbj6Lomemxb6HHYRKelkowXNhHNnujDEGPA2q1D00HYOkbd5JL7d8kdXdq1TJLeHG5syg6ro3BvkfgDOPVk2g</recordid><startdate>197903</startdate><enddate>197903</enddate><creator>Murillo, J</creator><creator>Standiford, H C</creator><creator>Tatem, B A</creator><creator>Caplan, E S</creator><creator>Calia, F M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197903</creationdate><title>Parenteral prophylaxis against enterococcal endocarditis</title><author>Murillo, J ; Standiford, H C ; Tatem, B A ; Caplan, E S ; Calia, F M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c309t-c2a45fab65723a7ab9c9fbe3373d51529fb040b04ed846cb61c68e20be69643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Ampicillin - administration & dosage</topic><topic>Ampicillin - therapeutic use</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Anti-Bacterial Agents - blood</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Endocarditis, Bacterial - prevention & control</topic><topic>Enterobacteriaceae Infections - prevention & control</topic><topic>Humans</topic><topic>Infusions, Parenteral</topic><topic>Injections, Intramuscular</topic><topic>Male</topic><topic>Penicillin G - administration & dosage</topic><topic>Penicillin G - therapeutic use</topic><topic>Penicillin G Procaine - administration & dosage</topic><topic>Penicillin G Procaine - therapeutic use</topic><topic>Streptomycin - administration & dosage</topic><topic>Streptomycin - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Murillo, J</creatorcontrib><creatorcontrib>Standiford, H C</creatorcontrib><creatorcontrib>Tatem, B A</creatorcontrib><creatorcontrib>Caplan, E S</creatorcontrib><creatorcontrib>Calia, F M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of the medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Murillo, J</au><au>Standiford, H C</au><au>Tatem, B A</au><au>Caplan, E S</au><au>Calia, F M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Parenteral prophylaxis against enterococcal endocarditis</atitle><jtitle>The American journal of the medical sciences</jtitle><addtitle>Am J Med Sci</addtitle><date>1979-03</date><risdate>1979</risdate><volume>277</volume><issue>2</issue><spage>195</spage><epage>200</epage><pages>195-200</pages><issn>0002-9629</issn><abstract>Three commonly used antibiotic regimens for the prevention of enterococcal endocarditis were administered parenterally to six healthy men in a crossover manner. 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| source | MEDLINE; Journals@Ovid Ovid Autoload |
| subjects | Ampicillin - administration & dosage Ampicillin - therapeutic use Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - blood Anti-Bacterial Agents - therapeutic use Endocarditis, Bacterial - prevention & control Enterobacteriaceae Infections - prevention & control Humans Infusions, Parenteral Injections, Intramuscular Male Penicillin G - administration & dosage Penicillin G - therapeutic use Penicillin G Procaine - administration & dosage Penicillin G Procaine - therapeutic use Streptomycin - administration & dosage Streptomycin - therapeutic use |
| title | Parenteral prophylaxis against enterococcal endocarditis |
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