The zinc-finger protein KCMF1 is overexpressed during pancreatic cancer development and downregulation of KCMF1 inhibits pancreatic cancer development in mice

Potassium channel modulatory factor 1 (KCMF1) was found upregulated in a differential screen in the metaplastic epithelium in the pancreas of transforming growth factor (TGF)-α transgenic mice. Expression analysis indicated broad overexpression in human cancer tissues. Therefore, we investigated the...

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Veröffentlicht in:	Oncogene 2010-07, Vol.29 (28), p.4058-4067
Hauptverfasser:	Beilke, S, Oswald, F, Genze, F, Wirth, T, Adler, G, Wagner, M
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1504/1713 692/420/2489/144/68 692/420/755 Animals Apoptosis Base Sequence Biological and medical sciences Care and treatment Cell Biology Cell culture Cell cycle Cell Line Cell physiology Cell proliferation Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Chorioallantoic membrane Cross-breeding Cyclin D Cyclin-dependent kinases Danio rerio DNA Primers Down-Regulation Embryogenesis Epithelium Fundamental and applied biological sciences. Psychology Gastroenterology. Liver. Pancreas. Abdomen Gene expression Genetic aspects Human Genetics Humans Hypotheses Internal Medicine Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Medicine Medicine & Public Health Mice Mice, Transgenic Molecular and cellular biology Oncology original-article Pancreatic cancer Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology Physiological aspects Proteins Risk factors Rodents Signal transduction Transforming growth factor-a Transgenic animals Transgenic mice Tumors Ubiquitin-Protein Ligases - genetics Zinc finger proteins
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