The anti-angiogenic activity of IL-12 is increased in iNOS−/− mice and involves NK cells

We have previously reported that the in vivo transfer of murine interleukin-12 (IL-12) gene using a Semliki Forest virus vector induced tumor regression through inhibition of tumor blood vessel formation. To examine whether IL-12 anti-angiogenic activity interferes with the NO pathway, we used induc...

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Veröffentlicht in:	Journal of molecular medicine (Berlin, Germany) Germany), 2010-08, Vol.88 (8), p.775-784
Hauptverfasser:	Bielawska-Pohl, Aleksandra, Blesson, Séverine, Benlalam, Houssem, Trenado, Aurélie, Opolon, Paule, Bawa, Olivia, Rouffiac, Valérie, Dus, Danuta, Kieda, Claudine, Chouaib, Salem
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biomedical and Life Sciences Biomedicine Endothelial Cells - pathology Gene Knockout Techniques General aspects Human Genetics Interleukin-12 - immunology Internal Medicine Killer Cells, Natural - immunology Killer Cells, Natural - pathology Medical sciences Melanoma, Experimental - blood supply Melanoma, Experimental - immunology Melanoma, Experimental - pathology Mice Mice, Inbred C57BL Molecular Medicine Neovascularization, Pathologic - immunology Neovascularization, Pathologic - pathology Nitric Oxide - immunology Nitric Oxide Synthase Type II - genetics Original Article Semliki Forest virus Vascular Endothelial Growth Factor A - immunology
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