Determination of the susceptibility of Mycobacterium tuberculosis to pyrazinamide in liquid and solid media assessed by a colorimetric nitrate reductase assay

Objectives The aim of this study was to develop and evaluate two colorimetric nitrate reductase-based antibiotic susceptibility (CONRAS) tests, the CONRAS-liquid test and the CONRAS-LJ test, to enable susceptibility testing of Mycobacterium tuberculosis to pyrazinamide. To enhance the growth of M. t...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2010-04, Vol.65 (4), p.704-712
Hauptverfasser:	Syre, Heidi, Øvreås, Kristi, Grewal, Harleen M. S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Antibiotics. Antiinfectious agents. Antiparasitic agents Antitubercular Agents - pharmacology Bacterial diseases Bioassays Biological and medical sciences Chemotherapy Colorimetry - economics Colorimetry - methods Culture Media - chemistry Drug resistance Gene expression Gram-positive bacteria Human bacterial diseases Humans Infectious diseases Medical sciences Microbial Sensitivity Tests - economics Microbial Sensitivity Tests - methods Mycobacterium Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Nitrate Reductase - metabolism nitrate reductase assay Nitrates Pharmacology. Drug treatments pyrazinamide Pyrazinamide - pharmacology Sensitivity and Specificity susceptibility test Time Factors Tuberculosis Tuberculosis and atypical mycobacterial infections
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