Autologous Bone Marrow–Derived Mesenchymal Stem Cells Versus Autologous Chondrocyte Implantation: An Observational Cohort Study
Background: First-generation autologous chondrocyte implantation has limitations, and introducing new effective cell sources can improve cartilage repair. Purpose: This study was conducted to compare the clinical outcomes of patients treated with first-generation autologous chondrocyte implantation...
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| Veröffentlicht in: | The American journal of sports medicine 2010-06, Vol.38 (6), p.1110-1116 |
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| creator | Nejadnik, Hossein Hui, James H. Feng Choong, Erica Pei Tai, Bee-Choo Lee, Eng Hin |
| description | Background: First-generation autologous chondrocyte implantation has limitations, and introducing new effective cell sources can improve cartilage repair.
Purpose: This study was conducted to compare the clinical outcomes of patients treated with first-generation autologous chondrocyte implantation to patients treated with autologous bone marrow–derived mesenchymal stem cells (BMSCs).
Study Design: Cohort study; Level of evidence, 3.
Methods: Seventy-two matched (lesion site and age) patients underwent cartilage repair using chondrocytes (n = 36) or BMSCs (n = 36). Clinical outcomes were measured before operation and 3, 6, 9, 12, 18, and 24 months after operation using the International Cartilage Repair Society (ICRS) Cartilage Injury Evaluation Package, which included questions from the Short-Form Health Survey, International Knee Documentation Committee (IKDC) subjective knee evaluation form, Lysholm knee scale, and Tegner activity level scale.
Results: There was significant improvement in the patients’ quality of life (physical and mental components of the Short Form-36 questionnaire included in the ICRS package) after cartilage repair in both groups (autologous chondrocyte implantation and BMSCs). However, there was no difference between the BMSC and the autologous chondrocyte implantation group in terms of clinical outcomes except for Physical Role Functioning, with a greater improvement over time in the BMSC group (P = .044 for interaction effect). The IKDC subjective knee evaluation (P = .861), Lysholm (P = .627), and Tegner (P = .200) scores did not show any significant difference between groups over time. However, in general, men showed significantly better improvements than women. Patients younger than 45 years of age scored significantly better than patients older than 45 years in the autologous chondrocyte implantation group, but age did not make a difference in outcomes in the BMSC group.
Conclusion: Using BMSCs in cartilage repair is as effective as chondrocytes for articular cartilage repair. In addition, it required 1 less knee surgery, reduced costs, and minimized donor-site morbidity. |
| doi_str_mv | 10.1177/0363546509359067 |
| format | Article |
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Purpose: This study was conducted to compare the clinical outcomes of patients treated with first-generation autologous chondrocyte implantation to patients treated with autologous bone marrow–derived mesenchymal stem cells (BMSCs).
Study Design: Cohort study; Level of evidence, 3.
Methods: Seventy-two matched (lesion site and age) patients underwent cartilage repair using chondrocytes (n = 36) or BMSCs (n = 36). Clinical outcomes were measured before operation and 3, 6, 9, 12, 18, and 24 months after operation using the International Cartilage Repair Society (ICRS) Cartilage Injury Evaluation Package, which included questions from the Short-Form Health Survey, International Knee Documentation Committee (IKDC) subjective knee evaluation form, Lysholm knee scale, and Tegner activity level scale.
Results: There was significant improvement in the patients’ quality of life (physical and mental components of the Short Form-36 questionnaire included in the ICRS package) after cartilage repair in both groups (autologous chondrocyte implantation and BMSCs). However, there was no difference between the BMSC and the autologous chondrocyte implantation group in terms of clinical outcomes except for Physical Role Functioning, with a greater improvement over time in the BMSC group (P = .044 for interaction effect). The IKDC subjective knee evaluation (P = .861), Lysholm (P = .627), and Tegner (P = .200) scores did not show any significant difference between groups over time. However, in general, men showed significantly better improvements than women. Patients younger than 45 years of age scored significantly better than patients older than 45 years in the autologous chondrocyte implantation group, but age did not make a difference in outcomes in the BMSC group.
Conclusion: Using BMSCs in cartilage repair is as effective as chondrocytes for articular cartilage repair. In addition, it required 1 less knee surgery, reduced costs, and minimized donor-site morbidity.</description><identifier>ISSN: 0363-5465</identifier><identifier>EISSN: 1552-3365</identifier><identifier>DOI: 10.1177/0363546509359067</identifier><identifier>PMID: 20392971</identifier><identifier>CODEN: AJSMDO</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Adult ; Biological and medical sciences ; Bone marrow ; Bone Marrow Cells ; Cartilage ; Chondrocytes - transplantation ; Clinical outcomes ; Cohort Studies ; Diseases of the osteoarticular system ; Female ; Humans ; Knee ; Knee Injuries - rehabilitation ; Knee Injuries - surgery ; Knee Joint - surgery ; Male ; Medical sciences ; Mesenchymal Stem Cell Transplantation - methods ; Middle Aged ; Observation ; Orthopedic Procedures - methods ; Orthopedic surgery ; Outcome Assessment (Health Care) - methods ; Quality of life ; Sports medicine ; Stem cells ; Studies ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surveys and Questionnaires ; Transplantation, Autologous ; Transplants & implants</subject><ispartof>The American journal of sports medicine, 2010-06, Vol.38 (6), p.1110-1116</ispartof><rights>2010 The Author(s)</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Sage Publications Ltd. Jun 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c406t-18081c271bb79ad953d13af3a3d21570ac87a028c7846eb2a3cdcfd5c60ad5b63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0363546509359067$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0363546509359067$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22908037$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20392971$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nejadnik, Hossein</creatorcontrib><creatorcontrib>Hui, James H.</creatorcontrib><creatorcontrib>Feng Choong, Erica Pei</creatorcontrib><creatorcontrib>Tai, Bee-Choo</creatorcontrib><creatorcontrib>Lee, Eng Hin</creatorcontrib><title>Autologous Bone Marrow–Derived Mesenchymal Stem Cells Versus Autologous Chondrocyte Implantation: An Observational Cohort Study</title><title>The American journal of sports medicine</title><addtitle>Am J Sports Med</addtitle><description>Background: First-generation autologous chondrocyte implantation has limitations, and introducing new effective cell sources can improve cartilage repair.
Purpose: This study was conducted to compare the clinical outcomes of patients treated with first-generation autologous chondrocyte implantation to patients treated with autologous bone marrow–derived mesenchymal stem cells (BMSCs).
Study Design: Cohort study; Level of evidence, 3.
Methods: Seventy-two matched (lesion site and age) patients underwent cartilage repair using chondrocytes (n = 36) or BMSCs (n = 36). Clinical outcomes were measured before operation and 3, 6, 9, 12, 18, and 24 months after operation using the International Cartilage Repair Society (ICRS) Cartilage Injury Evaluation Package, which included questions from the Short-Form Health Survey, International Knee Documentation Committee (IKDC) subjective knee evaluation form, Lysholm knee scale, and Tegner activity level scale.
Results: There was significant improvement in the patients’ quality of life (physical and mental components of the Short Form-36 questionnaire included in the ICRS package) after cartilage repair in both groups (autologous chondrocyte implantation and BMSCs). However, there was no difference between the BMSC and the autologous chondrocyte implantation group in terms of clinical outcomes except for Physical Role Functioning, with a greater improvement over time in the BMSC group (P = .044 for interaction effect). The IKDC subjective knee evaluation (P = .861), Lysholm (P = .627), and Tegner (P = .200) scores did not show any significant difference between groups over time. However, in general, men showed significantly better improvements than women. Patients younger than 45 years of age scored significantly better than patients older than 45 years in the autologous chondrocyte implantation group, but age did not make a difference in outcomes in the BMSC group.
Conclusion: Using BMSCs in cartilage repair is as effective as chondrocytes for articular cartilage repair. In addition, it required 1 less knee surgery, reduced costs, and minimized donor-site morbidity.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Bone marrow</subject><subject>Bone Marrow Cells</subject><subject>Cartilage</subject><subject>Chondrocytes - transplantation</subject><subject>Clinical outcomes</subject><subject>Cohort Studies</subject><subject>Diseases of the osteoarticular system</subject><subject>Female</subject><subject>Humans</subject><subject>Knee</subject><subject>Knee Injuries - rehabilitation</subject><subject>Knee Injuries - surgery</subject><subject>Knee Joint - surgery</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mesenchymal Stem Cell Transplantation - methods</subject><subject>Middle Aged</subject><subject>Observation</subject><subject>Orthopedic Procedures - methods</subject><subject>Orthopedic surgery</subject><subject>Outcome Assessment (Health Care) - methods</subject><subject>Quality of life</subject><subject>Sports medicine</subject><subject>Stem cells</subject><subject>Studies</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surveys and Questionnaires</subject><subject>Transplantation, Autologous</subject><subject>Transplants & implants</subject><issn>0363-5465</issn><issn>1552-3365</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUha0K1A6l-65QRIVYBa7t-G_ZDtBWasUC2m10YzttqiSe2glodrwDb8iTkGgGqCpVrLy43zn3XB9CDim8o1Sp98AlF4UUYLgwINUOWVAhWM65FM_IYh7n83yPvEjpDgCoknqX7DHghhlFF6Q6HofQhpswpuwk9D67xBjD918_fn7wsfnmXXbpk-_t7brDNvsy-C5b-rZN2bWPadI8kC9vQ-9isOvBZ-fdqsV-wKEJ_UvyvMY2-YPtu0-uPn38ujzLLz6fni-PL3JbgBxyqkFTyxStKmXQGcEd5Vhz5I5RoQCtVghMW6UL6SuG3DpbO2EloBOV5Pvk7cZ3FcP96NNQdk2yU1js_ZSvVIXkIIQW_yc5p5RJU0zk60fkXRhjP51RTl9caCnVDB09BVFDCwXaqHkpbCgbQ0rR1-UqNh3GdUmhnNssH7c5SV5tjceq8-6v4E99E_BmC2Cy2NYRe9ukfxwzoIHPRvmGS3jjH6R7avFvAX6z7Q</recordid><startdate>20100601</startdate><enddate>20100601</enddate><creator>Nejadnik, Hossein</creator><creator>Hui, James H.</creator><creator>Feng Choong, Erica Pei</creator><creator>Tai, Bee-Choo</creator><creator>Lee, Eng Hin</creator><general>SAGE Publications</general><general>Sage Publications</general><general>Sage Publications Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope><scope>7QP</scope></search><sort><creationdate>20100601</creationdate><title>Autologous Bone Marrow–Derived Mesenchymal Stem Cells Versus Autologous Chondrocyte Implantation</title><author>Nejadnik, Hossein ; Hui, James H. ; Feng Choong, Erica Pei ; Tai, Bee-Choo ; Lee, Eng Hin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-18081c271bb79ad953d13af3a3d21570ac87a028c7846eb2a3cdcfd5c60ad5b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Bone marrow</topic><topic>Bone Marrow Cells</topic><topic>Cartilage</topic><topic>Chondrocytes - transplantation</topic><topic>Clinical outcomes</topic><topic>Cohort Studies</topic><topic>Diseases of the osteoarticular system</topic><topic>Female</topic><topic>Humans</topic><topic>Knee</topic><topic>Knee Injuries - rehabilitation</topic><topic>Knee Injuries - surgery</topic><topic>Knee Joint - surgery</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mesenchymal Stem Cell Transplantation - methods</topic><topic>Middle Aged</topic><topic>Observation</topic><topic>Orthopedic Procedures - methods</topic><topic>Orthopedic surgery</topic><topic>Outcome Assessment (Health Care) - methods</topic><topic>Quality of life</topic><topic>Sports medicine</topic><topic>Stem cells</topic><topic>Studies</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surveys and Questionnaires</topic><topic>Transplantation, Autologous</topic><topic>Transplants & implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nejadnik, Hossein</creatorcontrib><creatorcontrib>Hui, James H.</creatorcontrib><creatorcontrib>Feng Choong, Erica Pei</creatorcontrib><creatorcontrib>Tai, Bee-Choo</creatorcontrib><creatorcontrib>Lee, Eng Hin</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><jtitle>The American journal of sports medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nejadnik, Hossein</au><au>Hui, James H.</au><au>Feng Choong, Erica Pei</au><au>Tai, Bee-Choo</au><au>Lee, Eng Hin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Autologous Bone Marrow–Derived Mesenchymal Stem Cells Versus Autologous Chondrocyte Implantation: An Observational Cohort Study</atitle><jtitle>The American journal of sports medicine</jtitle><addtitle>Am J Sports Med</addtitle><date>2010-06-01</date><risdate>2010</risdate><volume>38</volume><issue>6</issue><spage>1110</spage><epage>1116</epage><pages>1110-1116</pages><issn>0363-5465</issn><eissn>1552-3365</eissn><coden>AJSMDO</coden><abstract>Background: First-generation autologous chondrocyte implantation has limitations, and introducing new effective cell sources can improve cartilage repair.
Purpose: This study was conducted to compare the clinical outcomes of patients treated with first-generation autologous chondrocyte implantation to patients treated with autologous bone marrow–derived mesenchymal stem cells (BMSCs).
Study Design: Cohort study; Level of evidence, 3.
Methods: Seventy-two matched (lesion site and age) patients underwent cartilage repair using chondrocytes (n = 36) or BMSCs (n = 36). Clinical outcomes were measured before operation and 3, 6, 9, 12, 18, and 24 months after operation using the International Cartilage Repair Society (ICRS) Cartilage Injury Evaluation Package, which included questions from the Short-Form Health Survey, International Knee Documentation Committee (IKDC) subjective knee evaluation form, Lysholm knee scale, and Tegner activity level scale.
Results: There was significant improvement in the patients’ quality of life (physical and mental components of the Short Form-36 questionnaire included in the ICRS package) after cartilage repair in both groups (autologous chondrocyte implantation and BMSCs). However, there was no difference between the BMSC and the autologous chondrocyte implantation group in terms of clinical outcomes except for Physical Role Functioning, with a greater improvement over time in the BMSC group (P = .044 for interaction effect). The IKDC subjective knee evaluation (P = .861), Lysholm (P = .627), and Tegner (P = .200) scores did not show any significant difference between groups over time. However, in general, men showed significantly better improvements than women. Patients younger than 45 years of age scored significantly better than patients older than 45 years in the autologous chondrocyte implantation group, but age did not make a difference in outcomes in the BMSC group.
Conclusion: Using BMSCs in cartilage repair is as effective as chondrocytes for articular cartilage repair. In addition, it required 1 less knee surgery, reduced costs, and minimized donor-site morbidity.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>20392971</pmid><doi>10.1177/0363546509359067</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Bone marrow Bone Marrow Cells Cartilage Chondrocytes - transplantation Clinical outcomes Cohort Studies Diseases of the osteoarticular system Female Humans Knee Knee Injuries - rehabilitation Knee Injuries - surgery Knee Joint - surgery Male Medical sciences Mesenchymal Stem Cell Transplantation - methods Middle Aged Observation Orthopedic Procedures - methods Orthopedic surgery Outcome Assessment (Health Care) - methods Quality of life Sports medicine Stem cells Studies Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surveys and Questionnaires Transplantation, Autologous Transplants & implants |
| title | Autologous Bone Marrow–Derived Mesenchymal Stem Cells Versus Autologous Chondrocyte Implantation: An Observational Cohort Study |
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