Structure and Functional Expression of a Human Interleukin-8 Receptor
Interleukin-8 (IL-8) is a member of a family of pro-inflammatory cytokines. Although the best characterized activities of IL-8 include the chemoattraction and activation of neutrophils, other members of this family have a wide range of specific actions including the chemotaxis and activation of mono...
Gespeichert in:
| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1991-09, Vol.253 (5025), p.1278-1280 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1280 |
|---|---|
| container_issue | 5025 |
| container_start_page | 1278 |
| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 253 |
| creator | Holmes, William E. Lee, James Kuang, Wun-Jing Rice, Glenn C. Wood, William I. |
| description | Interleukin-8 (IL-8) is a member of a family of pro-inflammatory cytokines. Although the best characterized activities of IL-8 include the chemoattraction and activation of neutrophils, other members of this family have a wide range of specific actions including the chemotaxis and activation of monocytes, the selective chemotaxis of memory T cells, the inhibition of hematopoietic stem cell proliferation, and the induction of neutrophil infiltration in vivo. A complementary DNA encoding the IL-8 receptor from human neutrophils has now been isolated. The amino acid sequence shows that the receptor is a member of the superfamily of receptors that couple to guanine nucleotide binding proteins (G proteins). The sequence is 29% identical to that of receptors for the other neutrophil chemoattractants, fMet-Leu-Phe and C5a. Mammalian cells transfected with the IL-8 receptor cDNA clone bind IL-8 with high affinity and respond specifically to IL-8 by transiently mobilizing calcium. The IL-8 receptor may be part of a subfamily of related G protein-coupled receptors that transduce signals for the IL-8 family of pro-inflammatory cytokines. |
| doi_str_mv | 10.1126/science.1840701 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_746305272</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A11360655</galeid><jstor_id>2879178</jstor_id><sourcerecordid>A11360655</sourcerecordid><originalsourceid>FETCH-LOGICAL-c776t-ebffcbff986d50974a876e0c61f1b0ddb6840592085f8d760b13a7499c526ca53</originalsourceid><addsrcrecordid>eNqN081v0zAUAHALgUY3OHMBKeIAHJbNjhN_HEfVdZUqKjHgajnOS5WS2MVOpO2_x1WjoaIKKsuy4vfz00vyjNAbgq8Iydh1MA1YA1dE5Jhj8gxNCJZFKjNMn6MJxpSlAvPiJToPYYNxjEl6hs5GPkGz-94Pph88JNpWye1gTd84q9tk9rD1EEJ8SFyd6ORu6LRNFrYH38Lws7GpSL6CgW3v_Cv0otZtgNfjeoG-386-Te_S5Wq-mN4sU8M561Mo69rEKQWrCix5rgVngA0jNSlxVZUsllXE2kVRi4ozXBKqeS6lKTJmdEEv0Md93q13vwYIveqaYKBttQU3BMVzRnGR8ewESXPBOJNRfvi3jOVISth_IWGExeJ3Gd__BTdu8PGbBpURWkQjaESXe7TWLajG1q732qzBgtets1A3cfuGEMowK3Zvnh7hcVTQNeaY_3TgI-nhoV_rIQS1uP9yMl39OJl-np9KxXx5QC-PUePaFtagYgdNVwf8es-NdyF4qNXWN532j4pgtbsUarwUauzyeOLd-EOGsoPqj3-Kv93HNyE281M4E1wSLuhvnAsK8g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>213559283</pqid></control><display><type>article</type><title>Structure and Functional Expression of a Human Interleukin-8 Receptor</title><source>MEDLINE</source><source>JSTOR Archive Collection A-Z Listing</source><source>American Association for the Advancement of Science</source><creator>Holmes, William E. ; Lee, James ; Kuang, Wun-Jing ; Rice, Glenn C. ; Wood, William I.</creator><creatorcontrib>Holmes, William E. ; Lee, James ; Kuang, Wun-Jing ; Rice, Glenn C. ; Wood, William I.</creatorcontrib><description>Interleukin-8 (IL-8) is a member of a family of pro-inflammatory cytokines. Although the best characterized activities of IL-8 include the chemoattraction and activation of neutrophils, other members of this family have a wide range of specific actions including the chemotaxis and activation of monocytes, the selective chemotaxis of memory T cells, the inhibition of hematopoietic stem cell proliferation, and the induction of neutrophil infiltration in vivo. A complementary DNA encoding the IL-8 receptor from human neutrophils has now been isolated. The amino acid sequence shows that the receptor is a member of the superfamily of receptors that couple to guanine nucleotide binding proteins (G proteins). The sequence is 29% identical to that of receptors for the other neutrophil chemoattractants, fMet-Leu-Phe and C5a. Mammalian cells transfected with the IL-8 receptor cDNA clone bind IL-8 with high affinity and respond specifically to IL-8 by transiently mobilizing calcium. The IL-8 receptor may be part of a subfamily of related G protein-coupled receptors that transduce signals for the IL-8 family of pro-inflammatory cytokines.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1840701</identifier><identifier>PMID: 1840701</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>United States: American Society for the Advancement of Science</publisher><subject>Amino Acid Sequence ; Amino acid sequencing ; Amino acids ; Analysis ; Animals ; Antisense DNA ; B lymphocytes ; Cell Line ; Cell lines ; Cellular biology ; Cloning, Molecular ; Complementary DNA ; COS cells ; Deoxyribonucleic acid ; DNA ; DNA Probes ; Formyl peptide receptors ; genes ; Humans ; Immunity (Disease) ; Interleukin-8 - metabolism ; Kinetics ; leukocytes (neutrophilic) ; Membrane proteins ; Molecular Sequence Data ; Neutrophils ; Nucleic Acid Hybridization ; Plasmids ; Receptors ; Receptors, Immunologic - genetics ; Receptors, Immunologic - metabolism ; Receptors, Interleukin-8A ; Recombinant Proteins - metabolism ; RNA ; RNA, Messenger - genetics ; Sequence Homology, Nucleic Acid ; T lymphocytes ; Transfection</subject><ispartof>Science (American Association for the Advancement of Science), 1991-09, Vol.253 (5025), p.1278-1280</ispartof><rights>Copyright 1991 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1991 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1991 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Sep 13, 1991</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c776t-ebffcbff986d50974a876e0c61f1b0ddb6840592085f8d760b13a7499c526ca53</citedby><cites>FETCH-LOGICAL-c776t-ebffcbff986d50974a876e0c61f1b0ddb6840592085f8d760b13a7499c526ca53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2879178$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2879178$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,2882,2883,27922,27923,58015,58248</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1840701$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Holmes, William E.</creatorcontrib><creatorcontrib>Lee, James</creatorcontrib><creatorcontrib>Kuang, Wun-Jing</creatorcontrib><creatorcontrib>Rice, Glenn C.</creatorcontrib><creatorcontrib>Wood, William I.</creatorcontrib><title>Structure and Functional Expression of a Human Interleukin-8 Receptor</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Interleukin-8 (IL-8) is a member of a family of pro-inflammatory cytokines. Although the best characterized activities of IL-8 include the chemoattraction and activation of neutrophils, other members of this family have a wide range of specific actions including the chemotaxis and activation of monocytes, the selective chemotaxis of memory T cells, the inhibition of hematopoietic stem cell proliferation, and the induction of neutrophil infiltration in vivo. A complementary DNA encoding the IL-8 receptor from human neutrophils has now been isolated. The amino acid sequence shows that the receptor is a member of the superfamily of receptors that couple to guanine nucleotide binding proteins (G proteins). The sequence is 29% identical to that of receptors for the other neutrophil chemoattractants, fMet-Leu-Phe and C5a. Mammalian cells transfected with the IL-8 receptor cDNA clone bind IL-8 with high affinity and respond specifically to IL-8 by transiently mobilizing calcium. The IL-8 receptor may be part of a subfamily of related G protein-coupled receptors that transduce signals for the IL-8 family of pro-inflammatory cytokines.</description><subject>Amino Acid Sequence</subject><subject>Amino acid sequencing</subject><subject>Amino acids</subject><subject>Analysis</subject><subject>Animals</subject><subject>Antisense DNA</subject><subject>B lymphocytes</subject><subject>Cell Line</subject><subject>Cell lines</subject><subject>Cellular biology</subject><subject>Cloning, Molecular</subject><subject>Complementary DNA</subject><subject>COS cells</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA Probes</subject><subject>Formyl peptide receptors</subject><subject>genes</subject><subject>Humans</subject><subject>Immunity (Disease)</subject><subject>Interleukin-8 - metabolism</subject><subject>Kinetics</subject><subject>leukocytes (neutrophilic)</subject><subject>Membrane proteins</subject><subject>Molecular Sequence Data</subject><subject>Neutrophils</subject><subject>Nucleic Acid Hybridization</subject><subject>Plasmids</subject><subject>Receptors</subject><subject>Receptors, Immunologic - genetics</subject><subject>Receptors, Immunologic - metabolism</subject><subject>Receptors, Interleukin-8A</subject><subject>Recombinant Proteins - metabolism</subject><subject>RNA</subject><subject>RNA, Messenger - genetics</subject><subject>Sequence Homology, Nucleic Acid</subject><subject>T lymphocytes</subject><subject>Transfection</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN081v0zAUAHALgUY3OHMBKeIAHJbNjhN_HEfVdZUqKjHgajnOS5WS2MVOpO2_x1WjoaIKKsuy4vfz00vyjNAbgq8Iydh1MA1YA1dE5Jhj8gxNCJZFKjNMn6MJxpSlAvPiJToPYYNxjEl6hs5GPkGz-94Pph88JNpWye1gTd84q9tk9rD1EEJ8SFyd6ORu6LRNFrYH38Lws7GpSL6CgW3v_Cv0otZtgNfjeoG-386-Te_S5Wq-mN4sU8M561Mo69rEKQWrCix5rgVngA0jNSlxVZUsllXE2kVRi4ozXBKqeS6lKTJmdEEv0Md93q13vwYIveqaYKBttQU3BMVzRnGR8ewESXPBOJNRfvi3jOVISth_IWGExeJ3Gd__BTdu8PGbBpURWkQjaESXe7TWLajG1q732qzBgtets1A3cfuGEMowK3Zvnh7hcVTQNeaY_3TgI-nhoV_rIQS1uP9yMl39OJl-np9KxXx5QC-PUePaFtagYgdNVwf8es-NdyF4qNXWN532j4pgtbsUarwUauzyeOLd-EOGsoPqj3-Kv93HNyE281M4E1wSLuhvnAsK8g</recordid><startdate>19910913</startdate><enddate>19910913</enddate><creator>Holmes, William E.</creator><creator>Lee, James</creator><creator>Kuang, Wun-Jing</creator><creator>Rice, Glenn C.</creator><creator>Wood, William I.</creator><general>American Society for the Advancement of Science</general><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>0-V</scope><scope>3V.</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9-</scope><scope>K9.</scope><scope>KB.</scope><scope>KR7</scope><scope>L6V</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0K</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>7T5</scope><scope>M81</scope><scope>7X8</scope></search><sort><creationdate>19910913</creationdate><title>Structure and Functional Expression of a Human Interleukin-8 Receptor</title><author>Holmes, William E. ; Lee, James ; Kuang, Wun-Jing ; Rice, Glenn C. ; Wood, William I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c776t-ebffcbff986d50974a876e0c61f1b0ddb6840592085f8d760b13a7499c526ca53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Amino Acid Sequence</topic><topic>Amino acid sequencing</topic><topic>Amino acids</topic><topic>Analysis</topic><topic>Animals</topic><topic>Antisense DNA</topic><topic>B lymphocytes</topic><topic>Cell Line</topic><topic>Cell lines</topic><topic>Cellular biology</topic><topic>Cloning, Molecular</topic><topic>Complementary DNA</topic><topic>COS cells</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA Probes</topic><topic>Formyl peptide receptors</topic><topic>genes</topic><topic>Humans</topic><topic>Immunity (Disease)</topic><topic>Interleukin-8 - metabolism</topic><topic>Kinetics</topic><topic>leukocytes (neutrophilic)</topic><topic>Membrane proteins</topic><topic>Molecular Sequence Data</topic><topic>Neutrophils</topic><topic>Nucleic Acid Hybridization</topic><topic>Plasmids</topic><topic>Receptors</topic><topic>Receptors, Immunologic - genetics</topic><topic>Receptors, Immunologic - metabolism</topic><topic>Receptors, Interleukin-8A</topic><topic>Recombinant Proteins - metabolism</topic><topic>RNA</topic><topic>RNA, Messenger - genetics</topic><topic>Sequence Homology, Nucleic Acid</topic><topic>T lymphocytes</topic><topic>Transfection</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Holmes, William E.</creatorcontrib><creatorcontrib>Lee, James</creatorcontrib><creatorcontrib>Kuang, Wun-Jing</creatorcontrib><creatorcontrib>Rice, Glenn C.</creatorcontrib><creatorcontrib>Wood, William I.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>Gale In Context: Biography</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Canada</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Aluminium Industry Abstracts</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Education Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Education Collection</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Civil Engineering Abstracts</collection><collection>ProQuest Engineering Collection</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>ProQuest Biological Science Collection</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Agricultural Science Database</collection><collection>Education Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database (ProQuest)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Research Library (Corporate)</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Education</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>University of Michigan</collection><collection>Genetics Abstracts</collection><collection>Immunology Abstracts</collection><collection>Biochemistry Abstracts 3</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Holmes, William E.</au><au>Lee, James</au><au>Kuang, Wun-Jing</au><au>Rice, Glenn C.</au><au>Wood, William I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structure and Functional Expression of a Human Interleukin-8 Receptor</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1991-09-13</date><risdate>1991</risdate><volume>253</volume><issue>5025</issue><spage>1278</spage><epage>1280</epage><pages>1278-1280</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Interleukin-8 (IL-8) is a member of a family of pro-inflammatory cytokines. Although the best characterized activities of IL-8 include the chemoattraction and activation of neutrophils, other members of this family have a wide range of specific actions including the chemotaxis and activation of monocytes, the selective chemotaxis of memory T cells, the inhibition of hematopoietic stem cell proliferation, and the induction of neutrophil infiltration in vivo. A complementary DNA encoding the IL-8 receptor from human neutrophils has now been isolated. The amino acid sequence shows that the receptor is a member of the superfamily of receptors that couple to guanine nucleotide binding proteins (G proteins). The sequence is 29% identical to that of receptors for the other neutrophil chemoattractants, fMet-Leu-Phe and C5a. Mammalian cells transfected with the IL-8 receptor cDNA clone bind IL-8 with high affinity and respond specifically to IL-8 by transiently mobilizing calcium. The IL-8 receptor may be part of a subfamily of related G protein-coupled receptors that transduce signals for the IL-8 family of pro-inflammatory cytokines.</abstract><cop>United States</cop><pub>American Society for the Advancement of Science</pub><pmid>1840701</pmid><doi>10.1126/science.1840701</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1991-09, Vol.253 (5025), p.1278-1280 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_746305272 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; American Association for the Advancement of Science |
| subjects | Amino Acid Sequence Amino acid sequencing Amino acids Analysis Animals Antisense DNA B lymphocytes Cell Line Cell lines Cellular biology Cloning, Molecular Complementary DNA COS cells Deoxyribonucleic acid DNA DNA Probes Formyl peptide receptors genes Humans Immunity (Disease) Interleukin-8 - metabolism Kinetics leukocytes (neutrophilic) Membrane proteins Molecular Sequence Data Neutrophils Nucleic Acid Hybridization Plasmids Receptors Receptors, Immunologic - genetics Receptors, Immunologic - metabolism Receptors, Interleukin-8A Recombinant Proteins - metabolism RNA RNA, Messenger - genetics Sequence Homology, Nucleic Acid T lymphocytes Transfection |
| title | Structure and Functional Expression of a Human Interleukin-8 Receptor |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T16%3A13%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Structure%20and%20Functional%20Expression%20of%20a%20Human%20Interleukin-8%20Receptor&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Holmes,%20William%20E.&rft.date=1991-09-13&rft.volume=253&rft.issue=5025&rft.spage=1278&rft.epage=1280&rft.pages=1278-1280&rft.issn=0036-8075&rft.eissn=1095-9203&rft.coden=SCIEAS&rft_id=info:doi/10.1126/science.1840701&rft_dat=%3Cgale_proqu%3EA11360655%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=213559283&rft_id=info:pmid/1840701&rft_galeid=A11360655&rft_jstor_id=2879178&rfr_iscdi=true |