Thyroid hormone responsive Spot 14 increases during differentiation of human adipocytes and its expression is down-regulated in obese subjects
Context: Very limited information is available regarding the function of human thyroid hormone responsive Spot 14 (human S14, hS14) in adipogenesis and human adiposity. Objective: To evaluate hS14 levels during differentiation of human pre-adipocytes, in human fat depots and isolated fat cells. Desi...
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| Veröffentlicht in: | International Journal of Obesity 2010-03, Vol.34 (3), p.487-499 |
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| creator | Ortega, F.J Vazquez-Martin, A Moreno-Navarrete, J.M Bassols, J Rodriguez-Hermosa, J Girones, J Ricart, W Peral, B Tinahones, F.J Fruhbeck, G Menendez, J.A Fernandez-Real, J.M |
| description | Context: Very limited information is available regarding the function of human thyroid hormone responsive Spot 14 (human S14, hS14) in adipogenesis and human adiposity. Objective: To evaluate hS14 levels during differentiation of human pre-adipocytes, in human fat depots and isolated fat cells. Design: This was a cross-sectional study. Subjects: A total of 161 omental (OM) and 87 subcutaneous (SC) adipose tissue samples obtained during elective surgical procedures from a population who varied widely in terms of obesity.Measurements: hS14 gene expression and protein levels during adipogenesis were assessed by RT–PCR, western blot, and using an automated confocal imaging approach. Results: hS14 gene expression levels were decreased in OM adipose tissue from overweight (−42.0%) and obese subjects (−56.5%) compared with lean subjects (P |
| doi_str_mv | 10.1038/ijo.2009.263 |
| format | Article |
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Objective: To evaluate hS14 levels during differentiation of human pre-adipocytes, in human fat depots and isolated fat cells. Design: This was a cross-sectional study. Subjects: A total of 161 omental (OM) and 87 subcutaneous (SC) adipose tissue samples obtained during elective surgical procedures from a population who varied widely in terms of obesity.Measurements: hS14 gene expression and protein levels during adipogenesis were assessed by RT–PCR, western blot, and using an automated confocal imaging approach. Results: hS14 gene expression levels were decreased in OM adipose tissue from overweight (−42.0%) and obese subjects (−56.5%) compared with lean subjects (P<0.05 and P<0.0001, respectively). hS14 mRNA (but not hS14-related) was inversely associated with obesity measures such as body mass index (P=0.001), percent fat mass (P=0.001), waist-to-hip ratio (P=0.020), and systolic blood pressure (P=0.031). hS14 gene expression and protein levels were up-regulated at the early stages of differentiation of human pre-adipocytes as well as for 3T3-L1 cells. That observation was most prominent in those individual cells exhibiting the more marked differentiation features. hS14 gene expression levels increased by approximately 45 000-fold in mature adipocytes. Increased hS14 levels were also found in stromal-vascular cells/pre-adipocytes (3.8-fold, P<0.05) and in adipose tissue samples (1.9-fold, P<0.0001) from SC compared with OM fat depots. Conclusions: These results suggest that hS14 is involved in human adipogenesis, but inversely related to obesity and OM fat accumulation.</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/ijo.2009.263</identifier><identifier>PMID: 20029374</identifier><identifier>CODEN: IJOBDP</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>3T3-L1 Cells ; Adipocytes ; Adipocytes - cytology ; Adipocytes - metabolism ; Adipogenesis - genetics ; Adipose tissue ; Adipose Tissue - metabolism ; Adipose tissues ; Animals ; Automation ; Biological and medical sciences ; Blood pressure ; Blotting, Western ; Body fat ; body mass index ; Care and treatment ; cell differentiation ; Cell Differentiation - genetics ; Cells, Cultured ; Cross-Sectional Studies ; Diabetes ; Down-Regulation ; Endocrinology ; Epidemiology ; Fatty acids ; Gene Expression ; gene expression regulation ; genes ; Genetic aspects ; Glucose ; Health Promotion and Disease Prevention ; human diseases ; Humans ; Internal Medicine ; Kinases ; lipogenesis ; Medical sciences ; Medicine ; Medicine & Public Health ; messenger RNA ; Metabolic Diseases ; Mice ; Nuclear Proteins - genetics ; Nuclear Proteins - metabolism ; Nutrition ; Obesity ; Obesity - metabolism ; Omentum - metabolism ; original-article ; overweight ; Overweight - metabolism ; Physiological aspects ; pre-adipocytes ; Proteins ; Public Health ; Reverse Transcriptase Polymerase Chain Reaction ; subcutaneous fat ; Subcutaneous Fat - metabolism ; systolic blood pressure ; Thyroid ; Thyroid gland ; Thyroid Hormone Receptors alpha - genetics ; Thyroid Hormone Receptors alpha - metabolism ; Thyroid hormones ; Transcription Factors - genetics ; Transcription Factors - metabolism ; visceral fat ; waist-to-hip ratio</subject><ispartof>International Journal of Obesity, 2010-03, Vol.34 (3), p.487-499</ispartof><rights>Macmillan Publishers Limited 2010</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2010 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Mar 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c602t-5f3e4e314cb6fd46d6581aaaf39761f35668707fffb63fb68ecd8d474a30c9fe3</citedby><cites>FETCH-LOGICAL-c602t-5f3e4e314cb6fd46d6581aaaf39761f35668707fffb63fb68ecd8d474a30c9fe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ijo.2009.263$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/ijo.2009.263$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,2727,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22491116$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20029374$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ortega, F.J</creatorcontrib><creatorcontrib>Vazquez-Martin, A</creatorcontrib><creatorcontrib>Moreno-Navarrete, J.M</creatorcontrib><creatorcontrib>Bassols, J</creatorcontrib><creatorcontrib>Rodriguez-Hermosa, J</creatorcontrib><creatorcontrib>Girones, J</creatorcontrib><creatorcontrib>Ricart, W</creatorcontrib><creatorcontrib>Peral, B</creatorcontrib><creatorcontrib>Tinahones, F.J</creatorcontrib><creatorcontrib>Fruhbeck, G</creatorcontrib><creatorcontrib>Menendez, J.A</creatorcontrib><creatorcontrib>Fernandez-Real, J.M</creatorcontrib><title>Thyroid hormone responsive Spot 14 increases during differentiation of human adipocytes and its expression is down-regulated in obese subjects</title><title>International Journal of Obesity</title><addtitle>Int J Obes</addtitle><addtitle>Int J Obes (Lond)</addtitle><description>Context: Very limited information is available regarding the function of human thyroid hormone responsive Spot 14 (human S14, hS14) in adipogenesis and human adiposity. Objective: To evaluate hS14 levels during differentiation of human pre-adipocytes, in human fat depots and isolated fat cells. Design: This was a cross-sectional study. Subjects: A total of 161 omental (OM) and 87 subcutaneous (SC) adipose tissue samples obtained during elective surgical procedures from a population who varied widely in terms of obesity.Measurements: hS14 gene expression and protein levels during adipogenesis were assessed by RT–PCR, western blot, and using an automated confocal imaging approach. Results: hS14 gene expression levels were decreased in OM adipose tissue from overweight (−42.0%) and obese subjects (−56.5%) compared with lean subjects (P<0.05 and P<0.0001, respectively). hS14 mRNA (but not hS14-related) was inversely associated with obesity measures such as body mass index (P=0.001), percent fat mass (P=0.001), waist-to-hip ratio (P=0.020), and systolic blood pressure (P=0.031). hS14 gene expression and protein levels were up-regulated at the early stages of differentiation of human pre-adipocytes as well as for 3T3-L1 cells. That observation was most prominent in those individual cells exhibiting the more marked differentiation features. hS14 gene expression levels increased by approximately 45 000-fold in mature adipocytes. Increased hS14 levels were also found in stromal-vascular cells/pre-adipocytes (3.8-fold, P<0.05) and in adipose tissue samples (1.9-fold, P<0.0001) from SC compared with OM fat depots. Conclusions: These results suggest that hS14 is involved in human adipogenesis, but inversely related to obesity and OM fat accumulation.</description><subject>3T3-L1 Cells</subject><subject>Adipocytes</subject><subject>Adipocytes - cytology</subject><subject>Adipocytes - metabolism</subject><subject>Adipogenesis - genetics</subject><subject>Adipose tissue</subject><subject>Adipose Tissue - metabolism</subject><subject>Adipose tissues</subject><subject>Animals</subject><subject>Automation</subject><subject>Biological and medical sciences</subject><subject>Blood pressure</subject><subject>Blotting, Western</subject><subject>Body fat</subject><subject>body mass index</subject><subject>Care and treatment</subject><subject>cell differentiation</subject><subject>Cell Differentiation - genetics</subject><subject>Cells, Cultured</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes</subject><subject>Down-Regulation</subject><subject>Endocrinology</subject><subject>Epidemiology</subject><subject>Fatty acids</subject><subject>Gene Expression</subject><subject>gene expression regulation</subject><subject>genes</subject><subject>Genetic aspects</subject><subject>Glucose</subject><subject>Health Promotion and Disease Prevention</subject><subject>human diseases</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Kinases</subject><subject>lipogenesis</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>messenger RNA</subject><subject>Metabolic Diseases</subject><subject>Mice</subject><subject>Nuclear Proteins - genetics</subject><subject>Nuclear Proteins - metabolism</subject><subject>Nutrition</subject><subject>Obesity</subject><subject>Obesity - metabolism</subject><subject>Omentum - metabolism</subject><subject>original-article</subject><subject>overweight</subject><subject>Overweight - metabolism</subject><subject>Physiological aspects</subject><subject>pre-adipocytes</subject><subject>Proteins</subject><subject>Public Health</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>subcutaneous fat</subject><subject>Subcutaneous Fat - metabolism</subject><subject>systolic blood pressure</subject><subject>Thyroid</subject><subject>Thyroid gland</subject><subject>Thyroid Hormone Receptors alpha - genetics</subject><subject>Thyroid Hormone Receptors alpha - metabolism</subject><subject>Thyroid hormones</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><subject>visceral fat</subject><subject>waist-to-hip ratio</subject><issn>0307-0565</issn><issn>1476-5497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0k1v1DAQBuAIgWgp3DiDVQRcyOLvJMeq4kuqxKHt2fI6412vEjvYCbB_gt-MoywtRSAURZGsZ2Y08VsUTwleEczqt24XVhTjZkUlu1ccE17JUvCmul8cY4arEgspjopHKe0wxkJg-rA4yp42rOLHxY-r7T4G16JtiH3wgCKkIfjkvgK6HMKICEfOmwg6QULtFJ3foNZZCxH86PTogkfBou3Ua49064Zg9mOm2rfIjQnB9yG3TDNzuUH45ssIm6nTI2SQa9eQAKVpvQMzpsfFA6u7BE8O35Pi-v27q_OP5cXnD5_Ozy5KIzEdS2EZcGCEm7W0LZetFDXRWlvWVJJYJqSsK1xZa9eS5bcG09Ytr7hm2DQW2Enxeuk7xPBlgjSq3iUDXac9hCmpikuGBZX0_5KxPKmp6ixP_5C7MEWf11CUNJRLIqqMXixooztQztswRm3mluqMUlILzLjIavUXlZ8WemfyNVmXz-8UvPqtYAu6G7cpdNN8PekufLNAE0NKEawaout13CuC1ZwnlfOk5jypnKfMnx12mtY9tDf4V4AyeHkAOhnd2ai9cenWUd4QQmR25eLSMEcI4u3P-cdgtHivxynCTcOMZrOQ5wuxOii9iXns9SXFhGFSMybysj8BgDr1vg</recordid><startdate>20100301</startdate><enddate>20100301</enddate><creator>Ortega, F.J</creator><creator>Vazquez-Martin, A</creator><creator>Moreno-Navarrete, J.M</creator><creator>Bassols, J</creator><creator>Rodriguez-Hermosa, J</creator><creator>Girones, J</creator><creator>Ricart, W</creator><creator>Peral, B</creator><creator>Tinahones, F.J</creator><creator>Fruhbeck, G</creator><creator>Menendez, J.A</creator><creator>Fernandez-Real, J.M</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7TK</scope><scope>7TS</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>7U2</scope></search><sort><creationdate>20100301</creationdate><title>Thyroid hormone responsive Spot 14 increases during differentiation of human adipocytes and its expression is down-regulated in obese subjects</title><author>Ortega, F.J ; Vazquez-Martin, A ; Moreno-Navarrete, J.M ; Bassols, J ; Rodriguez-Hermosa, J ; Girones, J ; Ricart, W ; Peral, B ; Tinahones, F.J ; Fruhbeck, G ; Menendez, J.A ; Fernandez-Real, J.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c602t-5f3e4e314cb6fd46d6581aaaf39761f35668707fffb63fb68ecd8d474a30c9fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>3T3-L1 Cells</topic><topic>Adipocytes</topic><topic>Adipocytes - cytology</topic><topic>Adipocytes - metabolism</topic><topic>Adipogenesis - genetics</topic><topic>Adipose tissue</topic><topic>Adipose Tissue - metabolism</topic><topic>Adipose tissues</topic><topic>Animals</topic><topic>Automation</topic><topic>Biological and medical sciences</topic><topic>Blood pressure</topic><topic>Blotting, Western</topic><topic>Body fat</topic><topic>body mass index</topic><topic>Care and treatment</topic><topic>cell differentiation</topic><topic>Cell Differentiation - genetics</topic><topic>Cells, Cultured</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes</topic><topic>Down-Regulation</topic><topic>Endocrinology</topic><topic>Epidemiology</topic><topic>Fatty acids</topic><topic>Gene Expression</topic><topic>gene expression regulation</topic><topic>genes</topic><topic>Genetic aspects</topic><topic>Glucose</topic><topic>Health Promotion and Disease Prevention</topic><topic>human diseases</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Kinases</topic><topic>lipogenesis</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>messenger RNA</topic><topic>Metabolic Diseases</topic><topic>Mice</topic><topic>Nuclear Proteins - genetics</topic><topic>Nuclear Proteins - metabolism</topic><topic>Nutrition</topic><topic>Obesity</topic><topic>Obesity - metabolism</topic><topic>Omentum - metabolism</topic><topic>original-article</topic><topic>overweight</topic><topic>Overweight - metabolism</topic><topic>Physiological aspects</topic><topic>pre-adipocytes</topic><topic>Proteins</topic><topic>Public Health</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>subcutaneous fat</topic><topic>Subcutaneous Fat - metabolism</topic><topic>systolic blood pressure</topic><topic>Thyroid</topic><topic>Thyroid gland</topic><topic>Thyroid Hormone Receptors alpha - genetics</topic><topic>Thyroid Hormone Receptors alpha - metabolism</topic><topic>Thyroid hormones</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><topic>visceral fat</topic><topic>waist-to-hip ratio</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ortega, F.J</creatorcontrib><creatorcontrib>Vazquez-Martin, A</creatorcontrib><creatorcontrib>Moreno-Navarrete, J.M</creatorcontrib><creatorcontrib>Bassols, J</creatorcontrib><creatorcontrib>Rodriguez-Hermosa, J</creatorcontrib><creatorcontrib>Girones, J</creatorcontrib><creatorcontrib>Ricart, W</creatorcontrib><creatorcontrib>Peral, B</creatorcontrib><creatorcontrib>Tinahones, F.J</creatorcontrib><creatorcontrib>Fruhbeck, G</creatorcontrib><creatorcontrib>Menendez, J.A</creatorcontrib><creatorcontrib>Fernandez-Real, J.M</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Safety Science and Risk</collection><jtitle>International Journal of Obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ortega, F.J</au><au>Vazquez-Martin, A</au><au>Moreno-Navarrete, J.M</au><au>Bassols, J</au><au>Rodriguez-Hermosa, J</au><au>Girones, J</au><au>Ricart, W</au><au>Peral, B</au><au>Tinahones, F.J</au><au>Fruhbeck, G</au><au>Menendez, J.A</au><au>Fernandez-Real, J.M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thyroid hormone responsive Spot 14 increases during differentiation of human adipocytes and its expression is down-regulated in obese subjects</atitle><jtitle>International Journal of Obesity</jtitle><stitle>Int J Obes</stitle><addtitle>Int J Obes (Lond)</addtitle><date>2010-03-01</date><risdate>2010</risdate><volume>34</volume><issue>3</issue><spage>487</spage><epage>499</epage><pages>487-499</pages><issn>0307-0565</issn><eissn>1476-5497</eissn><coden>IJOBDP</coden><abstract>Context: Very limited information is available regarding the function of human thyroid hormone responsive Spot 14 (human S14, hS14) in adipogenesis and human adiposity. Objective: To evaluate hS14 levels during differentiation of human pre-adipocytes, in human fat depots and isolated fat cells. Design: This was a cross-sectional study. Subjects: A total of 161 omental (OM) and 87 subcutaneous (SC) adipose tissue samples obtained during elective surgical procedures from a population who varied widely in terms of obesity.Measurements: hS14 gene expression and protein levels during adipogenesis were assessed by RT–PCR, western blot, and using an automated confocal imaging approach. Results: hS14 gene expression levels were decreased in OM adipose tissue from overweight (−42.0%) and obese subjects (−56.5%) compared with lean subjects (P<0.05 and P<0.0001, respectively). hS14 mRNA (but not hS14-related) was inversely associated with obesity measures such as body mass index (P=0.001), percent fat mass (P=0.001), waist-to-hip ratio (P=0.020), and systolic blood pressure (P=0.031). hS14 gene expression and protein levels were up-regulated at the early stages of differentiation of human pre-adipocytes as well as for 3T3-L1 cells. That observation was most prominent in those individual cells exhibiting the more marked differentiation features. hS14 gene expression levels increased by approximately 45 000-fold in mature adipocytes. Increased hS14 levels were also found in stromal-vascular cells/pre-adipocytes (3.8-fold, P<0.05) and in adipose tissue samples (1.9-fold, P<0.0001) from SC compared with OM fat depots. Conclusions: These results suggest that hS14 is involved in human adipogenesis, but inversely related to obesity and OM fat accumulation.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>20029374</pmid><doi>10.1038/ijo.2009.263</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Nature; SpringerNature Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | 3T3-L1 Cells Adipocytes Adipocytes - cytology Adipocytes - metabolism Adipogenesis - genetics Adipose tissue Adipose Tissue - metabolism Adipose tissues Animals Automation Biological and medical sciences Blood pressure Blotting, Western Body fat body mass index Care and treatment cell differentiation Cell Differentiation - genetics Cells, Cultured Cross-Sectional Studies Diabetes Down-Regulation Endocrinology Epidemiology Fatty acids Gene Expression gene expression regulation genes Genetic aspects Glucose Health Promotion and Disease Prevention human diseases Humans Internal Medicine Kinases lipogenesis Medical sciences Medicine Medicine & Public Health messenger RNA Metabolic Diseases Mice Nuclear Proteins - genetics Nuclear Proteins - metabolism Nutrition Obesity Obesity - metabolism Omentum - metabolism original-article overweight Overweight - metabolism Physiological aspects pre-adipocytes Proteins Public Health Reverse Transcriptase Polymerase Chain Reaction subcutaneous fat Subcutaneous Fat - metabolism systolic blood pressure Thyroid Thyroid gland Thyroid Hormone Receptors alpha - genetics Thyroid Hormone Receptors alpha - metabolism Thyroid hormones Transcription Factors - genetics Transcription Factors - metabolism visceral fat waist-to-hip ratio |
| title | Thyroid hormone responsive Spot 14 increases during differentiation of human adipocytes and its expression is down-regulated in obese subjects |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T18%3A47%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Thyroid%20hormone%20responsive%20Spot%2014%20increases%20during%20differentiation%20of%20human%20adipocytes%20and%20its%20expression%20is%20down-regulated%20in%20obese%20subjects&rft.jtitle=International%20Journal%20of%20Obesity&rft.au=Ortega,%20F.J&rft.date=2010-03-01&rft.volume=34&rft.issue=3&rft.spage=487&rft.epage=499&rft.pages=487-499&rft.issn=0307-0565&rft.eissn=1476-5497&rft.coden=IJOBDP&rft_id=info:doi/10.1038/ijo.2009.263&rft_dat=%3Cgale_proqu%3EA221850345%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=219246157&rft_id=info:pmid/20029374&rft_galeid=A221850345&rfr_iscdi=true |