Inhibition of anticancer drug efflux transporter P-glycoprotein by rosemary phytochemicals

The effects of dietary antioxidative and chemopreventive rosemary phytochemicals on the function of the human drug efflux transporter P-glycoprotein (MDR1, ABCB1) and multidrug resistance protein 1 (MRP1, ABCC1) were investigated using P-glycoprotein-overexpressing human carcinoma KB-C2 cells and hu...

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Veröffentlicht in:	Pharmacological research 2010-03, Vol.61 (3), p.259-263
Hauptverfasser:	Nabekura, Tomohiro, Yamaki, Takeshi, Hiroi, Takashi, Ueno, Kazuyuki, Kitagawa, Shuji
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer drug Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors ATP-Binding Cassette, Sub-Family B, Member 1 - physiology Daunorubicin - metabolism Drug transporter Humans KB Cells Multidrug Resistance-Associated Proteins P-glycoprotein Phytochemical Phytotherapy Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Leaves - chemistry Plant Leaves - physiology Rosemary Rosmarinus Rosmarinus - chemistry Rosmarinus - physiology
Online-Zugang:	Volltext
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