Plant derived omega-3-fatty acids protect mitochondrial function in the brain
Perilla frutescens seed oil (PFSO) represents a rich source of unsaturated fatty acids, especially of omega-3 linolenic acid and is commonly used as herbal food supplement with beneficial effects on the vascular system. The present study investigated the effects of PFSO on the central nervous system...
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| Veröffentlicht in: | Pharmacological research 2010-03, Vol.61 (3), p.234-241 |
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| container_title | Pharmacological research |
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| creator | Eckert, Gunter P. Franke, Cornelia Nöldner, Michael Rau, Oliver Wurglics, Mario Schubert-Zsilavecz, Manfred Müller, Walter E. |
| description | Perilla frutescens seed oil (PFSO) represents a rich source of unsaturated fatty acids, especially of omega-3 linolenic acid and is commonly used as herbal food supplement with beneficial effects on the vascular system. The present study investigated the effects of PFSO on the central nervous system (CNS) and provides new insight into potential mechanisms for protective properties of unsaturated fatty acids within the CNS. PFSO was administered chronically to guinea pigs and neuroprotective properties were assessed ex vivo in dissociated brain cells. Dissociated brain cells isolated from PFSO treated guinea pigs were less vulnerable against nitrosative stress as indicated by decreased levels of reactive oxygen species, by stabilized mitochondrial membrane potential and enhanced levels of adenosine-triphosphate. In the brain, levels of oleic, linoleic, arachidonic and docosahexaenoic acids were significantly enhanced. However, fatty acid composition and membrane dynamics of isolated synaptosomal plasma membranes were not affected. Our findings provide new insights into the potential mechanisms for the neuroprotective actions of unsaturated fatty acids and identified PFSO as promising nutraceutical and possible alternative to fish oil supplements to provide healthful activities in the brain. |
| doi_str_mv | 10.1016/j.phrs.2010.01.005 |
| format | Article |
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The present study investigated the effects of PFSO on the central nervous system (CNS) and provides new insight into potential mechanisms for protective properties of unsaturated fatty acids within the CNS. PFSO was administered chronically to guinea pigs and neuroprotective properties were assessed ex vivo in dissociated brain cells. Dissociated brain cells isolated from PFSO treated guinea pigs were less vulnerable against nitrosative stress as indicated by decreased levels of reactive oxygen species, by stabilized mitochondrial membrane potential and enhanced levels of adenosine-triphosphate. In the brain, levels of oleic, linoleic, arachidonic and docosahexaenoic acids were significantly enhanced. However, fatty acid composition and membrane dynamics of isolated synaptosomal plasma membranes were not affected. Our findings provide new insights into the potential mechanisms for the neuroprotective actions of unsaturated fatty acids and identified PFSO as promising nutraceutical and possible alternative to fish oil supplements to provide healthful activities in the brain.</description><identifier>ISSN: 1043-6618</identifier><identifier>EISSN: 1096-1186</identifier><identifier>DOI: 10.1016/j.phrs.2010.01.005</identifier><identifier>PMID: 20079842</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject><![CDATA[alpha-Linolenic Acid - administration & dosage ; alpha-Linolenic Acid - isolation & purification ; Animals ; Brain ; Brain Chemistry - drug effects ; Brain Chemistry - physiology ; Fatty Acids, Omega-3 - administration & dosage ; Fatty Acids, Omega-3 - isolation & purification ; Fish oil ; Guinea Pigs ; Male ; Mitochondria ; Mitochondria - drug effects ; Mitochondria - physiology ; Neuroprotection ; Neuroprotective Agents - administration & dosage ; Neuroprotective Agents - isolation & purification ; Nutraceutical ; Omega-3-fatty acids ; Perilla frutescens ; PFSO ; Plant Oils - administration & dosage ; Plant Oils - isolation & purification ; PUFA ; Supplement]]></subject><ispartof>Pharmacological research, 2010-03, Vol.61 (3), p.234-241</ispartof><rights>2010 Elsevier Ltd</rights><rights>2010 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-ba3200f2d8c5fed9751be0e080c09cffdd91bc9f716683693d5426d2b35cb8f23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.phrs.2010.01.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20079842$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eckert, Gunter P.</creatorcontrib><creatorcontrib>Franke, Cornelia</creatorcontrib><creatorcontrib>Nöldner, Michael</creatorcontrib><creatorcontrib>Rau, Oliver</creatorcontrib><creatorcontrib>Wurglics, Mario</creatorcontrib><creatorcontrib>Schubert-Zsilavecz, Manfred</creatorcontrib><creatorcontrib>Müller, Walter E.</creatorcontrib><title>Plant derived omega-3-fatty acids protect mitochondrial function in the brain</title><title>Pharmacological research</title><addtitle>Pharmacol Res</addtitle><description>Perilla frutescens seed oil (PFSO) represents a rich source of unsaturated fatty acids, especially of omega-3 linolenic acid and is commonly used as herbal food supplement with beneficial effects on the vascular system. The present study investigated the effects of PFSO on the central nervous system (CNS) and provides new insight into potential mechanisms for protective properties of unsaturated fatty acids within the CNS. PFSO was administered chronically to guinea pigs and neuroprotective properties were assessed ex vivo in dissociated brain cells. Dissociated brain cells isolated from PFSO treated guinea pigs were less vulnerable against nitrosative stress as indicated by decreased levels of reactive oxygen species, by stabilized mitochondrial membrane potential and enhanced levels of adenosine-triphosphate. In the brain, levels of oleic, linoleic, arachidonic and docosahexaenoic acids were significantly enhanced. However, fatty acid composition and membrane dynamics of isolated synaptosomal plasma membranes were not affected. Our findings provide new insights into the potential mechanisms for the neuroprotective actions of unsaturated fatty acids and identified PFSO as promising nutraceutical and possible alternative to fish oil supplements to provide healthful activities in the brain.</description><subject>alpha-Linolenic Acid - administration & dosage</subject><subject>alpha-Linolenic Acid - isolation & purification</subject><subject>Animals</subject><subject>Brain</subject><subject>Brain Chemistry - drug effects</subject><subject>Brain Chemistry - physiology</subject><subject>Fatty Acids, Omega-3 - administration & dosage</subject><subject>Fatty Acids, Omega-3 - isolation & purification</subject><subject>Fish oil</subject><subject>Guinea Pigs</subject><subject>Male</subject><subject>Mitochondria</subject><subject>Mitochondria - drug effects</subject><subject>Mitochondria - physiology</subject><subject>Neuroprotection</subject><subject>Neuroprotective Agents - administration & dosage</subject><subject>Neuroprotective Agents - isolation & purification</subject><subject>Nutraceutical</subject><subject>Omega-3-fatty acids</subject><subject>Perilla frutescens</subject><subject>PFSO</subject><subject>Plant Oils - administration & dosage</subject><subject>Plant Oils - isolation & purification</subject><subject>PUFA</subject><subject>Supplement</subject><issn>1043-6618</issn><issn>1096-1186</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1rGzEQhkVpaD7aP5BD0a2ndUbSrnYFuRTTfEBCckjOQiuNYhnvrivJBv_7ytjJsTnNMDzzMvMQcslgxoDJq-VsvYhpxqEMgM0Ami_kjIGSFWOd_Lrva1FJybpTcp7SEgBUzeAbOeUArepqfkYen1dmzNRhDFt0dBrwzVSi8ibnHTU2uETXccpoMx1CnuxiGl0MZkX9ZrQ5TCMNI80LpH00YfxOTrxZJfxxrBfk9ebPy_yueni6vZ__fqis6Npc9UaUCzx3nW08OtU2rEdA6MCCst47p1hvlW-ZlJ2QSrim5tLxXjS27zwXF-TXIbfc9neDKeshJIur8gtOm6TbWgrgnKvPSSFaxXkjC8kPpI1TShG9XscwmLjTDPTet17qvW-9962B6eK7LP08xm_6Ad3HyrvgAlwfACw6tgGjTjbgaNGFWKRqN4X_5f8Ddb2ROg</recordid><startdate>20100301</startdate><enddate>20100301</enddate><creator>Eckert, Gunter P.</creator><creator>Franke, Cornelia</creator><creator>Nöldner, Michael</creator><creator>Rau, Oliver</creator><creator>Wurglics, Mario</creator><creator>Schubert-Zsilavecz, Manfred</creator><creator>Müller, Walter E.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20100301</creationdate><title>Plant derived omega-3-fatty acids protect mitochondrial function in the brain</title><author>Eckert, Gunter P. ; 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| subjects | alpha-Linolenic Acid - administration & dosage alpha-Linolenic Acid - isolation & purification Animals Brain Brain Chemistry - drug effects Brain Chemistry - physiology Fatty Acids, Omega-3 - administration & dosage Fatty Acids, Omega-3 - isolation & purification Fish oil Guinea Pigs Male Mitochondria Mitochondria - drug effects Mitochondria - physiology Neuroprotection Neuroprotective Agents - administration & dosage Neuroprotective Agents - isolation & purification Nutraceutical Omega-3-fatty acids Perilla frutescens PFSO Plant Oils - administration & dosage Plant Oils - isolation & purification PUFA Supplement |
| title | Plant derived omega-3-fatty acids protect mitochondrial function in the brain |
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