APC mutation spectrum of Norwegian familial adenomatous polyposis families: high ratio of novel mutations

Introduction Familial adenomatous polyposis (FAP) is an autosomal dominantly inherited disease caused by mutations in the adenomatous polyposis coli (APC) gene. Massive formation of colorectal adenomas, of which some will inevitably develop into adenocarcinomas, is the hallmark of the disease. Chara...

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Veröffentlicht in:Journal of cancer research and clinical oncology 2009-10, Vol.135 (10), p.1463-1470
Hauptverfasser: Andresen, Per Arne, Heimdal, Ketil, Aaberg, Kristin, Eklo, Kristin, Ariansen, Sarah, Silye, Alexandra, Fausa, Olav, Aabakken, Lars, Aretz, Stefan, Eide, Tor J, Gedde-Dahl, Tobias Jr
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Sprache:eng
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