Total Synthesis and Initial Structure-Activity Relationships of Longicatenamycin A

Natural products have provided the majority of lead structures for marketed antibacterials. In addition, they are biological guide principles to new therapies. Nevertheless, numerous “old” classes of antibiotics such as the longicatenamycins have never been explored by chemical postevolution. Longic...

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Veröffentlicht in:	ChemMedChem 2008-04, Vol.3 (4), p.619-626
Hauptverfasser:	von Nussbaum, Franz, Anlauf, Sonja, Freiberg, Christoph, Benet-Buchholz, Jordi, Schamberger, Jens, Henkel, Thomas, Schiffer, Guido, Häbich, Dieter
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis antibiotics Cyclization cyclopeptides Gram-positive bacteria Models, Molecular Peptides - chemical synthesis Peptides - chemistry Peptides - pharmacology Structure-Activity Relationship structure-activity relationships
Online-Zugang:	Volltext
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