Protective effect of triterpenoid fractions from the rhizomes of Astilbe chinensis on cyclophosphamide-induced toxicity in tumor-bearing mice
The objectives of this study were to investigate the protective effect of the triterpenoid fractions from the rhizomes of Astilbe chinensis (Saxifragaceae) (ATF) on cyclophosphamide (CTX)-induced toxicity in tumor-bearing mice. The mice inoculated with mouse sarcoma S180 cells were treated with sali...
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| Veröffentlicht in: | Journal of ethnopharmacology 2008-09, Vol.119 (2), p.312-317 |
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| creator | Sun, Hong-Xiang Peng, Xiao-Ying |
| description | The objectives of this study were to investigate the protective effect of the triterpenoid fractions from the rhizomes of
Astilbe chinensis (Saxifragaceae) (ATF) on cyclophosphamide (CTX)-induced toxicity in tumor-bearing mice.
The mice inoculated with mouse sarcoma S180 cells were treated with saline or CTX alone, or co-treated with CTX and ATF. The blood, femur bone, and serum samples were collected for determination of the haematological and biochemical parameters and splenocytes were for assay of proliferation, the activity of natural killer (NK) cells, and production of interleukin-2 (IL-2).
ATF significantly increased the peripheral white blood cell (WBC) count and bone marrow cellularity (BMC) in CTX-treated S180-bearing mice. Increase of aspartate transanimase (AST), alanine transaminase (ALT), urea nitrogen (BUN), and creatinine in the serum of CTX-treated mice was significantly reversed by ATF. The lowered levels of splenocytes proliferation, NK cells activity, and IL-2 production from splenocytes in S180-bearing mice after CTX treatment were also increased by ATF administration.
ATF provides significant protection against CTX-induced hematotoxicity, hepatotoxicity, nephrotoxicity, and immunotoxicity, and might be helpful in abrogation of CTX-induced toxicity during the chemotherapy. |
| doi_str_mv | 10.1016/j.jep.2008.07.017 |
| format | Article |
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Astilbe chinensis (Saxifragaceae) (ATF) on cyclophosphamide (CTX)-induced toxicity in tumor-bearing mice.
The mice inoculated with mouse sarcoma S180 cells were treated with saline or CTX alone, or co-treated with CTX and ATF. The blood, femur bone, and serum samples were collected for determination of the haematological and biochemical parameters and splenocytes were for assay of proliferation, the activity of natural killer (NK) cells, and production of interleukin-2 (IL-2).
ATF significantly increased the peripheral white blood cell (WBC) count and bone marrow cellularity (BMC) in CTX-treated S180-bearing mice. Increase of aspartate transanimase (AST), alanine transaminase (ALT), urea nitrogen (BUN), and creatinine in the serum of CTX-treated mice was significantly reversed by ATF. The lowered levels of splenocytes proliferation, NK cells activity, and IL-2 production from splenocytes in S180-bearing mice after CTX treatment were also increased by ATF administration.
ATF provides significant protection against CTX-induced hematotoxicity, hepatotoxicity, nephrotoxicity, and immunotoxicity, and might be helpful in abrogation of CTX-induced toxicity during the chemotherapy.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2008.07.017</identifier><identifier>PMID: 18692125</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>adverse effects ; alanine transaminase ; animal models ; Animals ; Antineoplastic Agents, Alkylating - toxicity ; aspartate transaminase ; Astilbe ; Astilbe chinensis ; Biological and medical sciences ; blood chemistry ; Blood Urea Nitrogen ; Bone Marrow Cells - metabolism ; Cell Line, Tumor ; cell proliferation ; Cell Proliferation - drug effects ; creatinine ; Creatinine - blood ; Cyclophosphamide ; Cyclophosphamide - toxicity ; Female ; femur ; General pharmacology ; hematology ; Hematotoxicity ; Hepatotoxicity ; Humans ; Immunotoxicity ; interleukin-2 ; Interleukin-2 - biosynthesis ; Killer Cells, Natural - drug effects ; Killer Cells, Natural - metabolism ; leukocyte count ; Leukocyte Count - methods ; Liver - drug effects ; Liver - metabolism ; Liver Function Tests ; Male ; Medical sciences ; medicinal plants ; medicinal properties ; Mice ; Mice, Inbred ICR ; natural killer cells ; neoplasms ; Nephrotoxicity ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; protective effect ; Rhizome ; rhizomes ; sarcoma ; Sarcoma 180 - drug therapy ; Saxifragaceae ; Saxifragaceae - chemistry ; Spleen - cytology ; Spleen - drug effects ; splenocytes ; Triterpenes - isolation & purification ; Triterpenes - pharmacology ; Triterpenoids ; Tumor-bearing mice ; urea nitrogen</subject><ispartof>Journal of ethnopharmacology, 2008-09, Vol.119 (2), p.312-317</ispartof><rights>2008 Elsevier Ireland Ltd</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-d07f41806e96dc884f9f1123009bde3370f3e19ee5c18e51c7ac705d300041bb3</citedby><cites>FETCH-LOGICAL-c437t-d07f41806e96dc884f9f1123009bde3370f3e19ee5c18e51c7ac705d300041bb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jep.2008.07.017$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20664620$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18692125$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Hong-Xiang</creatorcontrib><creatorcontrib>Peng, Xiao-Ying</creatorcontrib><title>Protective effect of triterpenoid fractions from the rhizomes of Astilbe chinensis on cyclophosphamide-induced toxicity in tumor-bearing mice</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>The objectives of this study were to investigate the protective effect of the triterpenoid fractions from the rhizomes of
Astilbe chinensis (Saxifragaceae) (ATF) on cyclophosphamide (CTX)-induced toxicity in tumor-bearing mice.
The mice inoculated with mouse sarcoma S180 cells were treated with saline or CTX alone, or co-treated with CTX and ATF. The blood, femur bone, and serum samples were collected for determination of the haematological and biochemical parameters and splenocytes were for assay of proliferation, the activity of natural killer (NK) cells, and production of interleukin-2 (IL-2).
ATF significantly increased the peripheral white blood cell (WBC) count and bone marrow cellularity (BMC) in CTX-treated S180-bearing mice. Increase of aspartate transanimase (AST), alanine transaminase (ALT), urea nitrogen (BUN), and creatinine in the serum of CTX-treated mice was significantly reversed by ATF. The lowered levels of splenocytes proliferation, NK cells activity, and IL-2 production from splenocytes in S180-bearing mice after CTX treatment were also increased by ATF administration.
ATF provides significant protection against CTX-induced hematotoxicity, hepatotoxicity, nephrotoxicity, and immunotoxicity, and might be helpful in abrogation of CTX-induced toxicity during the chemotherapy.</description><subject>adverse effects</subject><subject>alanine transaminase</subject><subject>animal models</subject><subject>Animals</subject><subject>Antineoplastic Agents, Alkylating - toxicity</subject><subject>aspartate transaminase</subject><subject>Astilbe</subject><subject>Astilbe chinensis</subject><subject>Biological and medical sciences</subject><subject>blood chemistry</subject><subject>Blood Urea Nitrogen</subject><subject>Bone Marrow Cells - metabolism</subject><subject>Cell Line, Tumor</subject><subject>cell proliferation</subject><subject>Cell Proliferation - drug effects</subject><subject>creatinine</subject><subject>Creatinine - blood</subject><subject>Cyclophosphamide</subject><subject>Cyclophosphamide - toxicity</subject><subject>Female</subject><subject>femur</subject><subject>General pharmacology</subject><subject>hematology</subject><subject>Hematotoxicity</subject><subject>Hepatotoxicity</subject><subject>Humans</subject><subject>Immunotoxicity</subject><subject>interleukin-2</subject><subject>Interleukin-2 - biosynthesis</subject><subject>Killer Cells, Natural - drug effects</subject><subject>Killer Cells, Natural - metabolism</subject><subject>leukocyte count</subject><subject>Leukocyte Count - methods</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Liver Function Tests</subject><subject>Male</subject><subject>Medical sciences</subject><subject>medicinal plants</subject><subject>medicinal properties</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>natural killer cells</subject><subject>neoplasms</subject><subject>Nephrotoxicity</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>protective effect</subject><subject>Rhizome</subject><subject>rhizomes</subject><subject>sarcoma</subject><subject>Sarcoma 180 - drug therapy</subject><subject>Saxifragaceae</subject><subject>Saxifragaceae - chemistry</subject><subject>Spleen - cytology</subject><subject>Spleen - drug effects</subject><subject>splenocytes</subject><subject>Triterpenes - isolation & purification</subject><subject>Triterpenes - pharmacology</subject><subject>Triterpenoids</subject><subject>Tumor-bearing mice</subject><subject>urea nitrogen</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v1DAQhiMEokvhB3ABXxCnhHG-nIhTVfElVQIJerYcZ9zMKrGD7VRd_gP_Ga92BTdOHtnPjEfvk2UvORQcePtuX-xxLUqArgBRABePsh3vRJmLRlSPsx1Uoss7UfOL7FkIewAQvIan2QXv2r7kZbPLfn_zLqKOdI8MjUkVc4ZFTxH9itbRyIxX6d3ZkCq3sDgh8xP9cguGI3sVIs0DMj2RRRsoXVqmD3p26-TCOqmFRszJjpvGkUX3QJrigZFlcVuczwdUnuwdW0jj8-yJUXPAF-fzMrv9-OHH9ef85uunL9dXN7muKxHzEYSpeQct9u2ou642veG8rAD6YcSqEmAq5D1io3mHDddCaQHNmACo-TBUl9nb09zVu58bhigXChrnWVl0W5Cibsu-bcsykfxEau9C8Gjk6mlR_iA5yKMEuZdJgjxKkCBkkpB6Xp2nb8OC47-Oc-oJeHMGVNBqTgFbTeEvV0LbpgUgca9PnFFOqjufmNvvJfAKeFOnD7tEvD8RmNK6J_QyaEKbkiafXMrR0X8W_QPkSrCt</recordid><startdate>20080926</startdate><enddate>20080926</enddate><creator>Sun, Hong-Xiang</creator><creator>Peng, Xiao-Ying</creator><general>Elsevier Ireland Ltd</general><general>Amsterdam; New York: Elsevier</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20080926</creationdate><title>Protective effect of triterpenoid fractions from the rhizomes of Astilbe chinensis on cyclophosphamide-induced toxicity in tumor-bearing mice</title><author>Sun, Hong-Xiang ; Peng, Xiao-Ying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-d07f41806e96dc884f9f1123009bde3370f3e19ee5c18e51c7ac705d300041bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>adverse effects</topic><topic>alanine transaminase</topic><topic>animal models</topic><topic>Animals</topic><topic>Antineoplastic Agents, Alkylating - toxicity</topic><topic>aspartate transaminase</topic><topic>Astilbe</topic><topic>Astilbe chinensis</topic><topic>Biological and medical sciences</topic><topic>blood chemistry</topic><topic>Blood Urea Nitrogen</topic><topic>Bone Marrow Cells - metabolism</topic><topic>Cell Line, Tumor</topic><topic>cell proliferation</topic><topic>Cell Proliferation - drug effects</topic><topic>creatinine</topic><topic>Creatinine - blood</topic><topic>Cyclophosphamide</topic><topic>Cyclophosphamide - toxicity</topic><topic>Female</topic><topic>femur</topic><topic>General pharmacology</topic><topic>hematology</topic><topic>Hematotoxicity</topic><topic>Hepatotoxicity</topic><topic>Humans</topic><topic>Immunotoxicity</topic><topic>interleukin-2</topic><topic>Interleukin-2 - biosynthesis</topic><topic>Killer Cells, Natural - drug effects</topic><topic>Killer Cells, Natural - metabolism</topic><topic>leukocyte count</topic><topic>Leukocyte Count - methods</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Liver Function Tests</topic><topic>Male</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>medicinal properties</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>natural killer cells</topic><topic>neoplasms</topic><topic>Nephrotoxicity</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>protective effect</topic><topic>Rhizome</topic><topic>rhizomes</topic><topic>sarcoma</topic><topic>Sarcoma 180 - drug therapy</topic><topic>Saxifragaceae</topic><topic>Saxifragaceae - chemistry</topic><topic>Spleen - cytology</topic><topic>Spleen - drug effects</topic><topic>splenocytes</topic><topic>Triterpenes - isolation & purification</topic><topic>Triterpenes - pharmacology</topic><topic>Triterpenoids</topic><topic>Tumor-bearing mice</topic><topic>urea nitrogen</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Hong-Xiang</creatorcontrib><creatorcontrib>Peng, Xiao-Ying</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Hong-Xiang</au><au>Peng, Xiao-Ying</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective effect of triterpenoid fractions from the rhizomes of Astilbe chinensis on cyclophosphamide-induced toxicity in tumor-bearing mice</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2008-09-26</date><risdate>2008</risdate><volume>119</volume><issue>2</issue><spage>312</spage><epage>317</epage><pages>312-317</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>The objectives of this study were to investigate the protective effect of the triterpenoid fractions from the rhizomes of
Astilbe chinensis (Saxifragaceae) (ATF) on cyclophosphamide (CTX)-induced toxicity in tumor-bearing mice.
The mice inoculated with mouse sarcoma S180 cells were treated with saline or CTX alone, or co-treated with CTX and ATF. The blood, femur bone, and serum samples were collected for determination of the haematological and biochemical parameters and splenocytes were for assay of proliferation, the activity of natural killer (NK) cells, and production of interleukin-2 (IL-2).
ATF significantly increased the peripheral white blood cell (WBC) count and bone marrow cellularity (BMC) in CTX-treated S180-bearing mice. Increase of aspartate transanimase (AST), alanine transaminase (ALT), urea nitrogen (BUN), and creatinine in the serum of CTX-treated mice was significantly reversed by ATF. The lowered levels of splenocytes proliferation, NK cells activity, and IL-2 production from splenocytes in S180-bearing mice after CTX treatment were also increased by ATF administration.
ATF provides significant protection against CTX-induced hematotoxicity, hepatotoxicity, nephrotoxicity, and immunotoxicity, and might be helpful in abrogation of CTX-induced toxicity during the chemotherapy.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>18692125</pmid><doi>10.1016/j.jep.2008.07.017</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of ethnopharmacology, 2008-09, Vol.119 (2), p.312-317 |
| issn | 0378-8741 1872-7573 |
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| subjects | adverse effects alanine transaminase animal models Animals Antineoplastic Agents, Alkylating - toxicity aspartate transaminase Astilbe Astilbe chinensis Biological and medical sciences blood chemistry Blood Urea Nitrogen Bone Marrow Cells - metabolism Cell Line, Tumor cell proliferation Cell Proliferation - drug effects creatinine Creatinine - blood Cyclophosphamide Cyclophosphamide - toxicity Female femur General pharmacology hematology Hematotoxicity Hepatotoxicity Humans Immunotoxicity interleukin-2 Interleukin-2 - biosynthesis Killer Cells, Natural - drug effects Killer Cells, Natural - metabolism leukocyte count Leukocyte Count - methods Liver - drug effects Liver - metabolism Liver Function Tests Male Medical sciences medicinal plants medicinal properties Mice Mice, Inbred ICR natural killer cells neoplasms Nephrotoxicity Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments protective effect Rhizome rhizomes sarcoma Sarcoma 180 - drug therapy Saxifragaceae Saxifragaceae - chemistry Spleen - cytology Spleen - drug effects splenocytes Triterpenes - isolation & purification Triterpenes - pharmacology Triterpenoids Tumor-bearing mice urea nitrogen |
| title | Protective effect of triterpenoid fractions from the rhizomes of Astilbe chinensis on cyclophosphamide-induced toxicity in tumor-bearing mice |
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