Calbindin-1 association and Parkinson's disease
Background and purpose: Calcium levels have been proposed to play an important role in the selective vulnerability of nigrostriatal dopaminergic neurons in Parkinson’s disease (PD). Recently, an association was reported between the calcium buffer, calbindin (rs1805874) and risk of PD in a Japanese...
Gespeichert in:
| Veröffentlicht in: | European journal of neurology 2010-02, Vol.17 (2), p.208-211 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 211 |
|---|---|
| container_issue | 2 |
| container_start_page | 208 |
| container_title | European journal of neurology |
| container_volume | 17 |
| creator | Soto-Ortolaza, A. I. Behrouz, B. Wider, C. Vilariño-Güell, C. Heckman, M. G. Aasly, J. O. Mark Gibson, J. Lynch, T. Jasinska-Myga, B. Krygowska-Wajs, A. Opala, G. Barcikowska, M. Czyzewski, K. Uitti, R. J. Wszolek, Z. K. Farrer, M. J. Ross, O. A. |
| description | Background and purpose: Calcium levels have been proposed to play an important role in the selective vulnerability of nigrostriatal dopaminergic neurons in Parkinson’s disease (PD). Recently, an association was reported between the calcium buffer, calbindin (rs1805874) and risk of PD in a Japanese patient–control series.
Methods: We genotyped rs1805874 in four independent Caucasian patient–control series (1543 PD patients, 1771 controls).
Results: There was no evidence of an association between rs1805874 and disease risk in individual populations or in the combined series (odds ratio: 1.04, 95% CI: 0.82–1.31, P = 0.74).
Discussion: Our study shows there is no association between rs1805874 and risk for PD in four Caucasian populations. This suggests the effect of calbindin on PD risk displays population specificity. |
| doi_str_mv | 10.1111/j.1468-1331.2009.02769.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_746285218</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4107865981</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4669-8ccc977b0bee7e3b0ab384f92e38783d0d22edb83c90302872d85a5dbf50403a3</originalsourceid><addsrcrecordid>eNqNkctOwzAQRS0E4lH4BRSJBauEsR0_smCBqrYgELDgsRw5sSu5pAnErSh_j0MrkNiANx7J585ojglJKGQ0nrNZRnOpU8o5zRhAkQFTsshWW2T_-2E71lzQVFCge-QghBlAxBjskj1aSJWDlPvkbGjq0jfWNylNTAht5c3Ct01iGpvcm-7FN6FtTkNifXAmuEOyMzV1cEebe0Aex6OH4WV6cze5Gl7cpFUuZZHqqqoKpUoonVOOl2BKrvNpwRzXSnMLljFnS82rAjgwrZjVwghbTgXkwA0fkNN139eufVu6sMC5D5Wra9O4dhlQ5ZJpwaj-m-RRRtw1j-TJL3LWLrsmroFUA5UgQIpI6TVVdW0InZvia-fnpvtACtjbxxn2krGXjL19_LKPqxg93gxYlnNnf4Ib3RE4XwPvvnYf_26Mo9tRX8V8us77sHCr73z8JpSKK4HPtxMU4ye4fpIcgX8CxMOe7w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1801605065</pqid></control><display><type>article</type><title>Calbindin-1 association and Parkinson's disease</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Soto-Ortolaza, A. I. ; Behrouz, B. ; Wider, C. ; Vilariño-Güell, C. ; Heckman, M. G. ; Aasly, J. O. ; Mark Gibson, J. ; Lynch, T. ; Jasinska-Myga, B. ; Krygowska-Wajs, A. ; Opala, G. ; Barcikowska, M. ; Czyzewski, K. ; Uitti, R. J. ; Wszolek, Z. K. ; Farrer, M. J. ; Ross, O. A.</creator><creatorcontrib>Soto-Ortolaza, A. I. ; Behrouz, B. ; Wider, C. ; Vilariño-Güell, C. ; Heckman, M. G. ; Aasly, J. O. ; Mark Gibson, J. ; Lynch, T. ; Jasinska-Myga, B. ; Krygowska-Wajs, A. ; Opala, G. ; Barcikowska, M. ; Czyzewski, K. ; Uitti, R. J. ; Wszolek, Z. K. ; Farrer, M. J. ; Ross, O. A.</creatorcontrib><description>Background and purpose: Calcium levels have been proposed to play an important role in the selective vulnerability of nigrostriatal dopaminergic neurons in Parkinson’s disease (PD). Recently, an association was reported between the calcium buffer, calbindin (rs1805874) and risk of PD in a Japanese patient–control series.
Methods: We genotyped rs1805874 in four independent Caucasian patient–control series (1543 PD patients, 1771 controls).
Results: There was no evidence of an association between rs1805874 and disease risk in individual populations or in the combined series (odds ratio: 1.04, 95% CI: 0.82–1.31, P = 0.74).
Discussion: Our study shows there is no association between rs1805874 and risk for PD in four Caucasian populations. This suggests the effect of calbindin on PD risk displays population specificity.</description><identifier>ISSN: 1351-5101</identifier><identifier>EISSN: 1468-1331</identifier><identifier>DOI: 10.1111/j.1468-1331.2009.02769.x</identifier><identifier>PMID: 19674066</identifier><identifier>CODEN: EJNEFL</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; association study ; Calbindin 1 ; Calbindins ; Case-Control Studies ; European Continental Ancestry Group - genetics ; Female ; Gene Frequency ; Genetic Association Studies ; Genetic Predisposition to Disease ; genetics ; Humans ; Ireland ; Male ; Middle Aged ; Norway ; Parkinson Disease - genetics ; Parkinson's disease ; Poland ; Polymorphism, Single Nucleotide ; Risk Factors ; S100 Calcium Binding Protein G - genetics ; Sequence Analysis, DNA ; United States</subject><ispartof>European journal of neurology, 2010-02, Vol.17 (2), p.208-211</ispartof><rights>2009 The Author(s). Journal compilation © 2009 EFNS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4669-8ccc977b0bee7e3b0ab384f92e38783d0d22edb83c90302872d85a5dbf50403a3</citedby><cites>FETCH-LOGICAL-c4669-8ccc977b0bee7e3b0ab384f92e38783d0d22edb83c90302872d85a5dbf50403a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1468-1331.2009.02769.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1468-1331.2009.02769.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19674066$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Soto-Ortolaza, A. I.</creatorcontrib><creatorcontrib>Behrouz, B.</creatorcontrib><creatorcontrib>Wider, C.</creatorcontrib><creatorcontrib>Vilariño-Güell, C.</creatorcontrib><creatorcontrib>Heckman, M. G.</creatorcontrib><creatorcontrib>Aasly, J. O.</creatorcontrib><creatorcontrib>Mark Gibson, J.</creatorcontrib><creatorcontrib>Lynch, T.</creatorcontrib><creatorcontrib>Jasinska-Myga, B.</creatorcontrib><creatorcontrib>Krygowska-Wajs, A.</creatorcontrib><creatorcontrib>Opala, G.</creatorcontrib><creatorcontrib>Barcikowska, M.</creatorcontrib><creatorcontrib>Czyzewski, K.</creatorcontrib><creatorcontrib>Uitti, R. J.</creatorcontrib><creatorcontrib>Wszolek, Z. K.</creatorcontrib><creatorcontrib>Farrer, M. J.</creatorcontrib><creatorcontrib>Ross, O. A.</creatorcontrib><title>Calbindin-1 association and Parkinson's disease</title><title>European journal of neurology</title><addtitle>Eur J Neurol</addtitle><description>Background and purpose: Calcium levels have been proposed to play an important role in the selective vulnerability of nigrostriatal dopaminergic neurons in Parkinson’s disease (PD). Recently, an association was reported between the calcium buffer, calbindin (rs1805874) and risk of PD in a Japanese patient–control series.
Methods: We genotyped rs1805874 in four independent Caucasian patient–control series (1543 PD patients, 1771 controls).
Results: There was no evidence of an association between rs1805874 and disease risk in individual populations or in the combined series (odds ratio: 1.04, 95% CI: 0.82–1.31, P = 0.74).
Discussion: Our study shows there is no association between rs1805874 and risk for PD in four Caucasian populations. This suggests the effect of calbindin on PD risk displays population specificity.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>association study</subject><subject>Calbindin 1</subject><subject>Calbindins</subject><subject>Case-Control Studies</subject><subject>European Continental Ancestry Group - genetics</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>genetics</subject><subject>Humans</subject><subject>Ireland</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Norway</subject><subject>Parkinson Disease - genetics</subject><subject>Parkinson's disease</subject><subject>Poland</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Risk Factors</subject><subject>S100 Calcium Binding Protein G - genetics</subject><subject>Sequence Analysis, DNA</subject><subject>United States</subject><issn>1351-5101</issn><issn>1468-1331</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkctOwzAQRS0E4lH4BRSJBauEsR0_smCBqrYgELDgsRw5sSu5pAnErSh_j0MrkNiANx7J585ojglJKGQ0nrNZRnOpU8o5zRhAkQFTsshWW2T_-2E71lzQVFCge-QghBlAxBjskj1aSJWDlPvkbGjq0jfWNylNTAht5c3Ct01iGpvcm-7FN6FtTkNifXAmuEOyMzV1cEebe0Aex6OH4WV6cze5Gl7cpFUuZZHqqqoKpUoonVOOl2BKrvNpwRzXSnMLljFnS82rAjgwrZjVwghbTgXkwA0fkNN139eufVu6sMC5D5Wra9O4dhlQ5ZJpwaj-m-RRRtw1j-TJL3LWLrsmroFUA5UgQIpI6TVVdW0InZvia-fnpvtACtjbxxn2krGXjL19_LKPqxg93gxYlnNnf4Ib3RE4XwPvvnYf_26Mo9tRX8V8us77sHCr73z8JpSKK4HPtxMU4ye4fpIcgX8CxMOe7w</recordid><startdate>201002</startdate><enddate>201002</enddate><creator>Soto-Ortolaza, A. I.</creator><creator>Behrouz, B.</creator><creator>Wider, C.</creator><creator>Vilariño-Güell, C.</creator><creator>Heckman, M. G.</creator><creator>Aasly, J. O.</creator><creator>Mark Gibson, J.</creator><creator>Lynch, T.</creator><creator>Jasinska-Myga, B.</creator><creator>Krygowska-Wajs, A.</creator><creator>Opala, G.</creator><creator>Barcikowska, M.</creator><creator>Czyzewski, K.</creator><creator>Uitti, R. J.</creator><creator>Wszolek, Z. K.</creator><creator>Farrer, M. J.</creator><creator>Ross, O. A.</creator><general>Blackwell Publishing Ltd</general><general>John Wiley & Sons, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope><scope>7QP</scope></search><sort><creationdate>201002</creationdate><title>Calbindin-1 association and Parkinson's disease</title><author>Soto-Ortolaza, A. I. ; Behrouz, B. ; Wider, C. ; Vilariño-Güell, C. ; Heckman, M. G. ; Aasly, J. O. ; Mark Gibson, J. ; Lynch, T. ; Jasinska-Myga, B. ; Krygowska-Wajs, A. ; Opala, G. ; Barcikowska, M. ; Czyzewski, K. ; Uitti, R. J. ; Wszolek, Z. K. ; Farrer, M. J. ; Ross, O. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4669-8ccc977b0bee7e3b0ab384f92e38783d0d22edb83c90302872d85a5dbf50403a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>association study</topic><topic>Calbindin 1</topic><topic>Calbindins</topic><topic>Case-Control Studies</topic><topic>European Continental Ancestry Group - genetics</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Association Studies</topic><topic>Genetic Predisposition to Disease</topic><topic>genetics</topic><topic>Humans</topic><topic>Ireland</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Norway</topic><topic>Parkinson Disease - genetics</topic><topic>Parkinson's disease</topic><topic>Poland</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Risk Factors</topic><topic>S100 Calcium Binding Protein G - genetics</topic><topic>Sequence Analysis, DNA</topic><topic>United States</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Soto-Ortolaza, A. I.</creatorcontrib><creatorcontrib>Behrouz, B.</creatorcontrib><creatorcontrib>Wider, C.</creatorcontrib><creatorcontrib>Vilariño-Güell, C.</creatorcontrib><creatorcontrib>Heckman, M. G.</creatorcontrib><creatorcontrib>Aasly, J. O.</creatorcontrib><creatorcontrib>Mark Gibson, J.</creatorcontrib><creatorcontrib>Lynch, T.</creatorcontrib><creatorcontrib>Jasinska-Myga, B.</creatorcontrib><creatorcontrib>Krygowska-Wajs, A.</creatorcontrib><creatorcontrib>Opala, G.</creatorcontrib><creatorcontrib>Barcikowska, M.</creatorcontrib><creatorcontrib>Czyzewski, K.</creatorcontrib><creatorcontrib>Uitti, R. J.</creatorcontrib><creatorcontrib>Wszolek, Z. K.</creatorcontrib><creatorcontrib>Farrer, M. J.</creatorcontrib><creatorcontrib>Ross, O. A.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><jtitle>European journal of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Soto-Ortolaza, A. I.</au><au>Behrouz, B.</au><au>Wider, C.</au><au>Vilariño-Güell, C.</au><au>Heckman, M. G.</au><au>Aasly, J. O.</au><au>Mark Gibson, J.</au><au>Lynch, T.</au><au>Jasinska-Myga, B.</au><au>Krygowska-Wajs, A.</au><au>Opala, G.</au><au>Barcikowska, M.</au><au>Czyzewski, K.</au><au>Uitti, R. J.</au><au>Wszolek, Z. K.</au><au>Farrer, M. J.</au><au>Ross, O. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Calbindin-1 association and Parkinson's disease</atitle><jtitle>European journal of neurology</jtitle><addtitle>Eur J Neurol</addtitle><date>2010-02</date><risdate>2010</risdate><volume>17</volume><issue>2</issue><spage>208</spage><epage>211</epage><pages>208-211</pages><issn>1351-5101</issn><eissn>1468-1331</eissn><coden>EJNEFL</coden><abstract>Background and purpose: Calcium levels have been proposed to play an important role in the selective vulnerability of nigrostriatal dopaminergic neurons in Parkinson’s disease (PD). Recently, an association was reported between the calcium buffer, calbindin (rs1805874) and risk of PD in a Japanese patient–control series.
Methods: We genotyped rs1805874 in four independent Caucasian patient–control series (1543 PD patients, 1771 controls).
Results: There was no evidence of an association between rs1805874 and disease risk in individual populations or in the combined series (odds ratio: 1.04, 95% CI: 0.82–1.31, P = 0.74).
Discussion: Our study shows there is no association between rs1805874 and risk for PD in four Caucasian populations. This suggests the effect of calbindin on PD risk displays population specificity.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19674066</pmid><doi>10.1111/j.1468-1331.2009.02769.x</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1351-5101 |
| ispartof | European journal of neurology, 2010-02, Vol.17 (2), p.208-211 |
| issn | 1351-5101 1468-1331 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_746285218 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Aged Aged, 80 and over association study Calbindin 1 Calbindins Case-Control Studies European Continental Ancestry Group - genetics Female Gene Frequency Genetic Association Studies Genetic Predisposition to Disease genetics Humans Ireland Male Middle Aged Norway Parkinson Disease - genetics Parkinson's disease Poland Polymorphism, Single Nucleotide Risk Factors S100 Calcium Binding Protein G - genetics Sequence Analysis, DNA United States |
| title | Calbindin-1 association and Parkinson's disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T17%3A26%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Calbindin-1%20association%20and%20Parkinson's%20disease&rft.jtitle=European%20journal%20of%20neurology&rft.au=Soto-Ortolaza,%20A.%20I.&rft.date=2010-02&rft.volume=17&rft.issue=2&rft.spage=208&rft.epage=211&rft.pages=208-211&rft.issn=1351-5101&rft.eissn=1468-1331&rft.coden=EJNEFL&rft_id=info:doi/10.1111/j.1468-1331.2009.02769.x&rft_dat=%3Cproquest_cross%3E4107865981%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1801605065&rft_id=info:pmid/19674066&rfr_iscdi=true |