Enhancer element potentially involved in human survivin gene promoter regulation in lung cancer cell lines

We have revealed evolutionarily conserved regions in a 4500-bp DNA sequence 5′-adjacent to the survivin ( BIRC5 ) gene. In the transcribed region of the BIRC5 gene we have detected and characterized in detail a 3′-fragment of the CpG island that stimulated in enhancer-like way the gene promoter acti...

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Veröffentlicht in:	Biochemistry (Moscow) 2010-02, Vol.75 (2), p.182-191
Hauptverfasser:	Mityaev, M. V., Kopantzev, E. P., Buzdin, A. A., Vinogradova, T. V., Sverdlov, E. D.
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Untranslated Regions - genetics Accelerated Publication Animals Base Sequence Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Cancer Care and treatment Cell Line, Tumor Cellular biology Computational Biology Conserved Sequence CpG Islands - genetics Deoxyribonucleic acid DNA DNA - chemistry DNA - genetics DNA - metabolism DNA sequencing Dogs Enhancer Elements, Genetic - genetics Gene expression Gene Expression Regulation, Neoplastic Gene therapy Genes Genetic aspects Genetics Genomics Health aspects Humans Inhibitor of Apoptosis Proteins Life Sciences Lung cancer Lung Neoplasms - genetics Lung Neoplasms - pathology Mice Microbiology Microtubule-Associated Proteins - genetics Nucleotide sequencing Promoter Regions, Genetic - genetics Simian virus 40 Tumor Suppressor Protein p53 - metabolism
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