Melatonin suppresses tumor angiogenesis by inhibiting HIF-1α stabilization under hypoxia

:  Angiogenesis is an important mediator of tumor progression. As tumors expand, diffusion distances from the existing vascular supply increases, resulting in hypoxia in the cancer cells. Sustained expansion of a tumor mass requires new blood vessel formation to provide rapidly proliferating tumor c...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of pineal research 2010-03, Vol.48 (2), p.178-184
Hauptverfasser:	Park, Shi-Young, Jang, Won-Jun, Yi, Eui-Yeun, Jang, Ji-Yeong, Jung, Yunjin, Jeong, Joo-Won, Kim, Yung-Jin
Format:	Artikel
Sprache:	eng
Schlagworte:	angiogenesis anti-oxidant Biological and medical sciences Fundamental and applied biological sciences. Psychology HIF-1α melatonin ROS VEGF Vertebrates: endocrinology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!