Antioxidant enzymatically modified isoquercitrin or melatonin supplementation reduces oxidative stress-mediated hepatocellular tumor promotion of oxfendazole in rats

To clarify whether enzymatically modified isoquercitrin (EMIQ) or melatonin (MLT) supplementation reduces oxidative stress-mediated hepatocellular tumor-promoting effect of oxfendazole (OX), a benzimidazole anthelmintic, male rats were administered a single intraperitoneal injection of N-diethylnitr...

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Veröffentlicht in:	Archives of toxicology 2010-02, Vol.84 (2), p.143-153
Hauptverfasser:	Nishimura, Jihei, Saegusa, Yukie, Dewa, Yasuaki, Jin, Meilan, Kawai, Masaomi, Kemmochi, Sayaka, Harada, Tomoaki, Hayashi, Shim-mo, Shibutani, Makoto, Mitsumori, Kunitoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	aldo-keto reductases Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antioxidants Antioxidants - metabolism Antiparasitic agents benzimidazole Benzimidazoles - pharmacology Biological and medical sciences Biomedical and Life Sciences Biomedicine Carcinogens - pharmacology cytochrome P-450 diet Dietary Supplements Environmental Health Enzymes family gene expression Genotoxicity and Carcinogenicity Hepatectomy hepatoma intraperitoneal injection isoquercitrin Liver Liver Neoplasms, Experimental - metabolism Liver Neoplasms, Experimental - pathology Male males malic enzyme Medical sciences melatonin Melatonin - metabolism Occupational Medicine/Industrial Medicine oxfendazole Oxidative Stress - drug effects Pharmacology. Drug treatments Pharmacology/Toxicology polypeptides Quercetin - analogs & derivatives Quercetin - metabolism Rats Rats, Inbred F344 reverse transcriptase polymerase chain reaction Rodents subfamily Toxicology
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