Dynamics of skeletal pattern formation in developing chick limb
During development of the embryonic chick limb the skeletal pattern is laid out as cartilaginous primordia, which emerge in a proximodistal sequence over a period of 4 days. The differentiation of cartilage is preceded by changes in cellular contacts at specific locations in the precartilage mesench...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1979-08, Vol.205 (4407), p.662-668 |
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| container_issue | 4407 |
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| creator | Newman, S.A Frisch, H.L |
| description | During development of the embryonic chick limb the skeletal pattern is laid out as cartilaginous primordia, which emerge in a proximodistal sequence over a period of 4 days. The differentiation of cartilage is preceded by changes in cellular contacts at specific locations in the precartilage mesenchyme. Under realistic assumptions, the biosynthesis and diffusion through the extracellular matrix of a cell surface protein, such as fibronectin, will lead to spatial patterns of this molecule that could be the basis of the emergent primordia. As cellular differentiation proceeds, the size of the mesenchymal diffusion chamber is reduced in discrete steps, leading to sequential reorganizations of the morphogen pattern. The successive patterns correspond to observed rows of skeletal elements, whose emergence, in theory and in practice, depends on the maintenance of a unique boundary condition at the limb bud apex. |
| doi_str_mv | 10.1126/science.462174 |
| format | Article |
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The differentiation of cartilage is preceded by changes in cellular contacts at specific locations in the precartilage mesenchyme. Under realistic assumptions, the biosynthesis and diffusion through the extracellular matrix of a cell surface protein, such as fibronectin, will lead to spatial patterns of this molecule that could be the basis of the emergent primordia. As cellular differentiation proceeds, the size of the mesenchymal diffusion chamber is reduced in discrete steps, leading to sequential reorganizations of the morphogen pattern. The successive patterns correspond to observed rows of skeletal elements, whose emergence, in theory and in practice, depends on the maintenance of a unique boundary condition at the limb bud apex.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.462174</identifier><identifier>PMID: 462174</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>Animal embryology ; Animals ; Biosynthesis ; Birds ; Bone and Bones - embryology ; Boundary conditions ; Cartilage ; Cell Differentiation ; Chick Embryo ; Chondrogenesis ; Condensation ; Diffusion ; Embryology ; Extracellular matrix ; Extremities (Anatomy) ; Extremities - embryology ; Growth ; Growth Substances - physiology ; Integument ; Limb buds ; Mesoderm - cytology ; Models, Biological ; Molecules ; Muscles - embryology ; Mutation ; Vertebrates ; Wings, Animal - embryology</subject><ispartof>Science (American Association for the Advancement of Science), 1979-08, Vol.205 (4407), p.662-668</ispartof><rights>Copyright 1979 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c461t-609e59afb0d9f79cc135616a56af3f2fff16c5d9d523e19b83fe8d29fa15e07e3</citedby><cites>FETCH-LOGICAL-c461t-609e59afb0d9f79cc135616a56af3f2fff16c5d9d523e19b83fe8d29fa15e07e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1748828$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1748828$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/462174$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Newman, S.A</creatorcontrib><creatorcontrib>Frisch, H.L</creatorcontrib><title>Dynamics of skeletal pattern formation in developing chick limb</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>During development of the embryonic chick limb the skeletal pattern is laid out as cartilaginous primordia, which emerge in a proximodistal sequence over a period of 4 days. The differentiation of cartilage is preceded by changes in cellular contacts at specific locations in the precartilage mesenchyme. Under realistic assumptions, the biosynthesis and diffusion through the extracellular matrix of a cell surface protein, such as fibronectin, will lead to spatial patterns of this molecule that could be the basis of the emergent primordia. As cellular differentiation proceeds, the size of the mesenchymal diffusion chamber is reduced in discrete steps, leading to sequential reorganizations of the morphogen pattern. The successive patterns correspond to observed rows of skeletal elements, whose emergence, in theory and in practice, depends on the maintenance of a unique boundary condition at the limb bud apex.</description><subject>Animal embryology</subject><subject>Animals</subject><subject>Biosynthesis</subject><subject>Birds</subject><subject>Bone and Bones - embryology</subject><subject>Boundary conditions</subject><subject>Cartilage</subject><subject>Cell Differentiation</subject><subject>Chick Embryo</subject><subject>Chondrogenesis</subject><subject>Condensation</subject><subject>Diffusion</subject><subject>Embryology</subject><subject>Extracellular matrix</subject><subject>Extremities (Anatomy)</subject><subject>Extremities - embryology</subject><subject>Growth</subject><subject>Growth Substances - physiology</subject><subject>Integument</subject><subject>Limb buds</subject><subject>Mesoderm - cytology</subject><subject>Models, Biological</subject><subject>Molecules</subject><subject>Muscles - embryology</subject><subject>Mutation</subject><subject>Vertebrates</subject><subject>Wings, Animal - embryology</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkL1PHDEQxa0ohBwkbQqUYisatIc_1va6itAFAhISBVBbPu_4YvDaF9uHwn-fRXtKpFRTvN-8efMQ-kLwkhAqzov1EC0sO0GJ7N6hBcGKt4pi9h4tMGai7bHkH9FRKU8YT5pih-jDTC_Qt--v0Yzelia5pjxDgGpCszW1Qo6NS3k01afY-NgM8AIhbX3cNPant89N8OP6EzpwJhT4vJ_H6PHq8mF13d7e_bhZXdy2thOktgIr4Mq4NR6Uk8pawrggwnBhHHPUOUeE5YMaOGVA1LpnDvqBKmcIByyBHaPT2Xeb068dlKpHXyyEYCKkXdFyeogTSSfwbAY3JoD20aZY4Xe1KQTYgJ5Cre70xXS-Y90bvZxpm1MpGZzeZj-a_KoJ1m_16n29ei5sWvi6z7FbjzD8xf-Xn0pN-Z-Z7Pqe9pN8MsvOJG022Rf9eC8VlZxS9gcUN4g-</recordid><startdate>19790817</startdate><enddate>19790817</enddate><creator>Newman, S.A</creator><creator>Frisch, H.L</creator><general>American Association for the Advancement of Science</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19790817</creationdate><title>Dynamics of skeletal pattern formation in developing chick limb</title><author>Newman, S.A ; Frisch, H.L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c461t-609e59afb0d9f79cc135616a56af3f2fff16c5d9d523e19b83fe8d29fa15e07e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Animal embryology</topic><topic>Animals</topic><topic>Biosynthesis</topic><topic>Birds</topic><topic>Bone and Bones - embryology</topic><topic>Boundary conditions</topic><topic>Cartilage</topic><topic>Cell Differentiation</topic><topic>Chick Embryo</topic><topic>Chondrogenesis</topic><topic>Condensation</topic><topic>Diffusion</topic><topic>Embryology</topic><topic>Extracellular matrix</topic><topic>Extremities (Anatomy)</topic><topic>Extremities - embryology</topic><topic>Growth</topic><topic>Growth Substances - physiology</topic><topic>Integument</topic><topic>Limb buds</topic><topic>Mesoderm - cytology</topic><topic>Models, Biological</topic><topic>Molecules</topic><topic>Muscles - embryology</topic><topic>Mutation</topic><topic>Vertebrates</topic><topic>Wings, Animal - embryology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Newman, S.A</creatorcontrib><creatorcontrib>Frisch, H.L</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Newman, S.A</au><au>Frisch, H.L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dynamics of skeletal pattern formation in developing chick limb</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1979-08-17</date><risdate>1979</risdate><volume>205</volume><issue>4407</issue><spage>662</spage><epage>668</epage><pages>662-668</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>During development of the embryonic chick limb the skeletal pattern is laid out as cartilaginous primordia, which emerge in a proximodistal sequence over a period of 4 days. The differentiation of cartilage is preceded by changes in cellular contacts at specific locations in the precartilage mesenchyme. Under realistic assumptions, the biosynthesis and diffusion through the extracellular matrix of a cell surface protein, such as fibronectin, will lead to spatial patterns of this molecule that could be the basis of the emergent primordia. As cellular differentiation proceeds, the size of the mesenchymal diffusion chamber is reduced in discrete steps, leading to sequential reorganizations of the morphogen pattern. The successive patterns correspond to observed rows of skeletal elements, whose emergence, in theory and in practice, depends on the maintenance of a unique boundary condition at the limb bud apex.</abstract><cop>United States</cop><pub>American Association for the Advancement of Science</pub><pmid>462174</pmid><doi>10.1126/science.462174</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1979-08, Vol.205 (4407), p.662-668 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74625172 |
| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Animal embryology Animals Biosynthesis Birds Bone and Bones - embryology Boundary conditions Cartilage Cell Differentiation Chick Embryo Chondrogenesis Condensation Diffusion Embryology Extracellular matrix Extremities (Anatomy) Extremities - embryology Growth Growth Substances - physiology Integument Limb buds Mesoderm - cytology Models, Biological Molecules Muscles - embryology Mutation Vertebrates Wings, Animal - embryology |
| title | Dynamics of skeletal pattern formation in developing chick limb |
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