Biocompatibility of Delrin 150: A creep-resistant polymer for total joint prostheses
A thermoplastic polymer, Delrin 150 (polyoxymethylene homopolymer), with creep resistance ten times that of ultrahigh‐molecular‐weight polyethylene, is used as a material for total joint protheses. A study was made of the local and systemic host response to this polymer when implanted in three diffe...
Gespeichert in:
Veröffentlicht in: | Journal of biomedical materials research 1985-05, Vol.19 (5), p.519-533 |
---|---|
Hauptverfasser: | , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 533 |
---|---|
container_issue | 5 |
container_start_page | 519 |
container_title | Journal of biomedical materials research |
container_volume | 19 |
creator | Fister, James S. Memoli, Vincent A. Galante, Jorge O. Rostoker, William Urban, Robert M. |
description | A thermoplastic polymer, Delrin 150 (polyoxymethylene homopolymer), with creep resistance ten times that of ultrahigh‐molecular‐weight polyethylene, is used as a material for total joint protheses. A study was made of the local and systemic host response to this polymer when implanted in three different mammalian species. 316 LC stainless steel was used as a control. The materials were implanted into muscle and bone as solid cylinders. A total of 446 samples were implanted into 74 animals. The duration of implantation ranged from 2 weeks to 2 years. A semiquantitative evaluation of local tissue reaction was performed. For each implant, 16 histological criteria were graded for severity of host tissue reaction. The liver, spleen, kidneys, pancreas, and lungs from each animal were also studied for evidence of systemic toxicity. The polymer implants exhibited a mild tissue reaction with the same characteristics as the control. Local tumor formation, bone osteolysis, and surrounding muscle necrosis were not seen. No pathological changes compatible with systemic toxicity by Delrin 150 were observed in the study of the organs. Delrin 150 in solid form did not exhibit local or systemic toxicity and is therefore biocompatible by this study. Powder implantation studies should be performed to simulate tissue response to wear particles. |
doi_str_mv | 10.1002/jbm.820190505 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_746248287</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>746248287</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4355-4d9f3665cc15300e4b0d474f0cd8a0ad6202f2efe31c8f5513bb41e7bacd37fd3</originalsourceid><addsrcrecordid>eNp9kE1v1DAQhi1EVbaFI0ckH5A4pR1_J9zaUpai8nFY1KPlOGPhJdksdlZl_z2uNlpx4mTJ7zMzrx5CXjO4YAD8ct0OFzUH1oAC9YwsGDSmklro52RRclY1AuQLcpbzGgCaRrBTcipBa8P1gqyu4-jHYeum2MY-Tns6BvoB-xQ3lCl4T6-oT4jbKmGOeXKbiW7Hfj9gomFMdBon19P1GJ_-05inn5gxvyQnwfUZX83vOfnx8XZ186m6_7a8u7m6r7wUSlWya4LQWnnPlABA2UInjQzgu9qB6zQHHjgGFMzXQSkm2lYyNK3znTChE-fk3WFvOf17h3myQ8we-95tcNxla6Tmsua1KWR1IH0pmRMGu01xcGlvGdgnjbZotEeNhX8zb961A3ZHevZW8rdz7rJ3fUhu42M-YrVk2iheMHPAHmOP-__ftJ-vv_xbYC5cpOOf46RLv6w2wij78HVpv3NmlquH2irxF1eKmaI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>746248287</pqid></control><display><type>article</type><title>Biocompatibility of Delrin 150: A creep-resistant polymer for total joint prostheses</title><source>MEDLINE</source><source>Wiley Online Library</source><creator>Fister, James S. ; Memoli, Vincent A. ; Galante, Jorge O. ; Rostoker, William ; Urban, Robert M.</creator><creatorcontrib>Fister, James S. ; Memoli, Vincent A. ; Galante, Jorge O. ; Rostoker, William ; Urban, Robert M.</creatorcontrib><description>A thermoplastic polymer, Delrin 150 (polyoxymethylene homopolymer), with creep resistance ten times that of ultrahigh‐molecular‐weight polyethylene, is used as a material for total joint protheses. A study was made of the local and systemic host response to this polymer when implanted in three different mammalian species. 316 LC stainless steel was used as a control. The materials were implanted into muscle and bone as solid cylinders. A total of 446 samples were implanted into 74 animals. The duration of implantation ranged from 2 weeks to 2 years. A semiquantitative evaluation of local tissue reaction was performed. For each implant, 16 histological criteria were graded for severity of host tissue reaction. The liver, spleen, kidneys, pancreas, and lungs from each animal were also studied for evidence of systemic toxicity. The polymer implants exhibited a mild tissue reaction with the same characteristics as the control. Local tumor formation, bone osteolysis, and surrounding muscle necrosis were not seen. No pathological changes compatible with systemic toxicity by Delrin 150 were observed in the study of the organs. Delrin 150 in solid form did not exhibit local or systemic toxicity and is therefore biocompatible by this study. Powder implantation studies should be performed to simulate tissue response to wear particles.</description><identifier>ISSN: 0021-9304</identifier><identifier>EISSN: 1097-4636</identifier><identifier>DOI: 10.1002/jbm.820190505</identifier><identifier>PMID: 4066726</identifier><identifier>CODEN: JBMRBG</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Animals ; Biocompatible Materials ; Biological and medical sciences ; biomedical engineering ; Bone and Bones - drug effects ; Bone and Bones - pathology ; Bone and Bones - surgery ; creep ; Dogs ; Evaluation Studies as Topic ; Joint Prosthesis ; Male ; materials testing ; mechanical properties ; Medical sciences ; Muscles - drug effects ; Muscles - pathology ; Muscles - surgery ; Orthopedic surgery ; polymers ; prosthetics ; Rabbits ; Rats ; Resins, Synthetic - toxicity ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><ispartof>Journal of biomedical materials research, 1985-05, Vol.19 (5), p.519-533</ispartof><rights>Copyright © 1985 John Wiley & Sons, Inc.</rights><rights>1986 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4355-4d9f3665cc15300e4b0d474f0cd8a0ad6202f2efe31c8f5513bb41e7bacd37fd3</citedby><cites>FETCH-LOGICAL-c4355-4d9f3665cc15300e4b0d474f0cd8a0ad6202f2efe31c8f5513bb41e7bacd37fd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjbm.820190505$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjbm.820190505$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8416752$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4066726$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fister, James S.</creatorcontrib><creatorcontrib>Memoli, Vincent A.</creatorcontrib><creatorcontrib>Galante, Jorge O.</creatorcontrib><creatorcontrib>Rostoker, William</creatorcontrib><creatorcontrib>Urban, Robert M.</creatorcontrib><title>Biocompatibility of Delrin 150: A creep-resistant polymer for total joint prostheses</title><title>Journal of biomedical materials research</title><addtitle>J. Biomed. Mater. Res</addtitle><description>A thermoplastic polymer, Delrin 150 (polyoxymethylene homopolymer), with creep resistance ten times that of ultrahigh‐molecular‐weight polyethylene, is used as a material for total joint protheses. A study was made of the local and systemic host response to this polymer when implanted in three different mammalian species. 316 LC stainless steel was used as a control. The materials were implanted into muscle and bone as solid cylinders. A total of 446 samples were implanted into 74 animals. The duration of implantation ranged from 2 weeks to 2 years. A semiquantitative evaluation of local tissue reaction was performed. For each implant, 16 histological criteria were graded for severity of host tissue reaction. The liver, spleen, kidneys, pancreas, and lungs from each animal were also studied for evidence of systemic toxicity. The polymer implants exhibited a mild tissue reaction with the same characteristics as the control. Local tumor formation, bone osteolysis, and surrounding muscle necrosis were not seen. No pathological changes compatible with systemic toxicity by Delrin 150 were observed in the study of the organs. Delrin 150 in solid form did not exhibit local or systemic toxicity and is therefore biocompatible by this study. Powder implantation studies should be performed to simulate tissue response to wear particles.</description><subject>Animals</subject><subject>Biocompatible Materials</subject><subject>Biological and medical sciences</subject><subject>biomedical engineering</subject><subject>Bone and Bones - drug effects</subject><subject>Bone and Bones - pathology</subject><subject>Bone and Bones - surgery</subject><subject>creep</subject><subject>Dogs</subject><subject>Evaluation Studies as Topic</subject><subject>Joint Prosthesis</subject><subject>Male</subject><subject>materials testing</subject><subject>mechanical properties</subject><subject>Medical sciences</subject><subject>Muscles - drug effects</subject><subject>Muscles - pathology</subject><subject>Muscles - surgery</subject><subject>Orthopedic surgery</subject><subject>polymers</subject><subject>prosthetics</subject><subject>Rabbits</subject><subject>Rats</subject><subject>Resins, Synthetic - toxicity</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><issn>0021-9304</issn><issn>1097-4636</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhi1EVbaFI0ckH5A4pR1_J9zaUpai8nFY1KPlOGPhJdksdlZl_z2uNlpx4mTJ7zMzrx5CXjO4YAD8ct0OFzUH1oAC9YwsGDSmklro52RRclY1AuQLcpbzGgCaRrBTcipBa8P1gqyu4-jHYeum2MY-Tns6BvoB-xQ3lCl4T6-oT4jbKmGOeXKbiW7Hfj9gomFMdBon19P1GJ_-05inn5gxvyQnwfUZX83vOfnx8XZ186m6_7a8u7m6r7wUSlWya4LQWnnPlABA2UInjQzgu9qB6zQHHjgGFMzXQSkm2lYyNK3znTChE-fk3WFvOf17h3myQ8we-95tcNxla6Tmsua1KWR1IH0pmRMGu01xcGlvGdgnjbZotEeNhX8zb961A3ZHevZW8rdz7rJ3fUhu42M-YrVk2iheMHPAHmOP-__ftJ-vv_xbYC5cpOOf46RLv6w2wij78HVpv3NmlquH2irxF1eKmaI</recordid><startdate>198505</startdate><enddate>198505</enddate><creator>Fister, James S.</creator><creator>Memoli, Vincent A.</creator><creator>Galante, Jorge O.</creator><creator>Rostoker, William</creator><creator>Urban, Robert M.</creator><general>John Wiley & Sons, Inc</general><general>John Wiley & Sons</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TC</scope></search><sort><creationdate>198505</creationdate><title>Biocompatibility of Delrin 150: A creep-resistant polymer for total joint prostheses</title><author>Fister, James S. ; Memoli, Vincent A. ; Galante, Jorge O. ; Rostoker, William ; Urban, Robert M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4355-4d9f3665cc15300e4b0d474f0cd8a0ad6202f2efe31c8f5513bb41e7bacd37fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animals</topic><topic>Biocompatible Materials</topic><topic>Biological and medical sciences</topic><topic>biomedical engineering</topic><topic>Bone and Bones - drug effects</topic><topic>Bone and Bones - pathology</topic><topic>Bone and Bones - surgery</topic><topic>creep</topic><topic>Dogs</topic><topic>Evaluation Studies as Topic</topic><topic>Joint Prosthesis</topic><topic>Male</topic><topic>materials testing</topic><topic>mechanical properties</topic><topic>Medical sciences</topic><topic>Muscles - drug effects</topic><topic>Muscles - pathology</topic><topic>Muscles - surgery</topic><topic>Orthopedic surgery</topic><topic>polymers</topic><topic>prosthetics</topic><topic>Rabbits</topic><topic>Rats</topic><topic>Resins, Synthetic - toxicity</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><toplevel>online_resources</toplevel><creatorcontrib>Fister, James S.</creatorcontrib><creatorcontrib>Memoli, Vincent A.</creatorcontrib><creatorcontrib>Galante, Jorge O.</creatorcontrib><creatorcontrib>Rostoker, William</creatorcontrib><creatorcontrib>Urban, Robert M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Mechanical Engineering Abstracts</collection><jtitle>Journal of biomedical materials research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fister, James S.</au><au>Memoli, Vincent A.</au><au>Galante, Jorge O.</au><au>Rostoker, William</au><au>Urban, Robert M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biocompatibility of Delrin 150: A creep-resistant polymer for total joint prostheses</atitle><jtitle>Journal of biomedical materials research</jtitle><addtitle>J. Biomed. Mater. Res</addtitle><date>1985-05</date><risdate>1985</risdate><volume>19</volume><issue>5</issue><spage>519</spage><epage>533</epage><pages>519-533</pages><issn>0021-9304</issn><eissn>1097-4636</eissn><coden>JBMRBG</coden><abstract>A thermoplastic polymer, Delrin 150 (polyoxymethylene homopolymer), with creep resistance ten times that of ultrahigh‐molecular‐weight polyethylene, is used as a material for total joint protheses. A study was made of the local and systemic host response to this polymer when implanted in three different mammalian species. 316 LC stainless steel was used as a control. The materials were implanted into muscle and bone as solid cylinders. A total of 446 samples were implanted into 74 animals. The duration of implantation ranged from 2 weeks to 2 years. A semiquantitative evaluation of local tissue reaction was performed. For each implant, 16 histological criteria were graded for severity of host tissue reaction. The liver, spleen, kidneys, pancreas, and lungs from each animal were also studied for evidence of systemic toxicity. The polymer implants exhibited a mild tissue reaction with the same characteristics as the control. Local tumor formation, bone osteolysis, and surrounding muscle necrosis were not seen. No pathological changes compatible with systemic toxicity by Delrin 150 were observed in the study of the organs. Delrin 150 in solid form did not exhibit local or systemic toxicity and is therefore biocompatible by this study. Powder implantation studies should be performed to simulate tissue response to wear particles.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>4066726</pmid><doi>10.1002/jbm.820190505</doi><tpages>15</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0021-9304 |
ispartof | Journal of biomedical materials research, 1985-05, Vol.19 (5), p.519-533 |
issn | 0021-9304 1097-4636 |
language | eng |
recordid | cdi_proquest_miscellaneous_746248287 |
source | MEDLINE; Wiley Online Library |
subjects | Animals Biocompatible Materials Biological and medical sciences biomedical engineering Bone and Bones - drug effects Bone and Bones - pathology Bone and Bones - surgery creep Dogs Evaluation Studies as Topic Joint Prosthesis Male materials testing mechanical properties Medical sciences Muscles - drug effects Muscles - pathology Muscles - surgery Orthopedic surgery polymers prosthetics Rabbits Rats Resins, Synthetic - toxicity Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases |
title | Biocompatibility of Delrin 150: A creep-resistant polymer for total joint prostheses |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T11%3A35%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Biocompatibility%20of%20Delrin%20150:%20A%20creep-resistant%20polymer%20for%20total%20joint%20prostheses&rft.jtitle=Journal%20of%20biomedical%20materials%20research&rft.au=Fister,%20James%20S.&rft.date=1985-05&rft.volume=19&rft.issue=5&rft.spage=519&rft.epage=533&rft.pages=519-533&rft.issn=0021-9304&rft.eissn=1097-4636&rft.coden=JBMRBG&rft_id=info:doi/10.1002/jbm.820190505&rft_dat=%3Cproquest_cross%3E746248287%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=746248287&rft_id=info:pmid/4066726&rfr_iscdi=true |