Antibacterial Nitric Oxide-Releasing Polyester for the Coating of Blood-Contacting Artificial Materials
The emergence of multidrug‐resistant bacteria associated with blood‐contacting artificial materials is a growing health problem, which demands new approaches in the field of biomaterials research. In this study, a poly(sulfhydrylated polyester) (PSPE) was synthesized by the polyesterification reacti...
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| Veröffentlicht in: | Artificial organs 2010-07, Vol.34 (7), p.E204-E214 |
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| container_title | Artificial organs |
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| creator | Seabra, Amedea B. Martins, Dorival Simões, Maíra M.S.G. Da Silva, Regiane Brocchi, Marcelo De Oliveira, Marcelo G. |
| description | The emergence of multidrug‐resistant bacteria associated with blood‐contacting artificial materials is a growing health problem, which demands new approaches in the field of biomaterials research. In this study, a poly(sulfhydrylated polyester) (PSPE) was synthesized by the polyesterification reaction of mercaptosuccinic acid with 3‐mercapto‐1,2‐propanediol and blended with poly(methyl methacrylate) (PMMA) from solution, leading to solid PSPE/PMMA films, with three different PSPE : PMMMA mass ratios. These films were subsequently S‐nitrosated through the immersion in acidified nitrite solution, yielding poly(nitrosated)polyester/PMMA (PNPE/PMMA) films. A polyurethane intravascular catheter coated with PNPE/PMMA was shown to release nitric oxide (NO) in phosphate buffered saline solution (pH 7.4) at 37°C at rates of 4.6 nmol/cm2/h in the first 6 h and 0.8 nmol/cm2/h in the next 12 h. When used to coat the bottom of culture plates, NO released from these films exerted a potent dose‐ and time‐dependent antimicrobial activity against Staphylococcus aureus and a multidrug‐resistant Pseudomonas aeruginosa strains. This antibacterial effect of PSPE/PMMA films opens a new perspective for the coating of blood‐contacting artificial materials, for avoiding their colonization with highly resistant bacteria. |
| doi_str_mv | 10.1111/j.1525-1594.2010.00998.x |
| format | Article |
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In this study, a poly(sulfhydrylated polyester) (PSPE) was synthesized by the polyesterification reaction of mercaptosuccinic acid with 3‐mercapto‐1,2‐propanediol and blended with poly(methyl methacrylate) (PMMA) from solution, leading to solid PSPE/PMMA films, with three different PSPE : PMMMA mass ratios. These films were subsequently S‐nitrosated through the immersion in acidified nitrite solution, yielding poly(nitrosated)polyester/PMMA (PNPE/PMMA) films. A polyurethane intravascular catheter coated with PNPE/PMMA was shown to release nitric oxide (NO) in phosphate buffered saline solution (pH 7.4) at 37°C at rates of 4.6 nmol/cm2/h in the first 6 h and 0.8 nmol/cm2/h in the next 12 h. When used to coat the bottom of culture plates, NO released from these films exerted a potent dose‐ and time‐dependent antimicrobial activity against Staphylococcus aureus and a multidrug‐resistant Pseudomonas aeruginosa strains. 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This antibacterial effect of PSPE/PMMA films opens a new perspective for the coating of blood‐contacting artificial materials, for avoiding their colonization with highly resistant bacteria.</description><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial action</subject><subject>Biocompatible Materials - chemical synthesis</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biocompatible Materials - pharmacology</subject><subject>Biomaterials</subject><subject>Blood-contacting artificial materials</subject><subject>Catheter-related infections</subject><subject>Catheters, Indwelling</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - administration & dosage</subject><subject>Nitric Oxide - pharmacology</subject><subject>Polyesters - chemical synthesis</subject><subject>Polyesters - chemistry</subject><subject>Polyesters - pharmacology</subject><subject>Polymethyl Methacrylate - chemical synthesis</subject><subject>Polymethyl Methacrylate - chemistry</subject><subject>Polymethyl Methacrylate - pharmacology</subject><subject>Pseudomonas aeruginosa</subject><subject>Pseudomonas aeruginosa - drug effects</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Sulfhydryl Compounds - chemical synthesis</subject><subject>Sulfhydryl Compounds - chemistry</subject><subject>Sulfhydryl Compounds - pharmacology</subject><issn>0160-564X</issn><issn>1525-1594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUUtPGzEYtKqiktL-hWpvPW3qt3clLumKpkiQoJTXzfKubXC6iVN7oyb_Hi8LuYIvnzXfzNiaASBDcIzS-bEcI4ZZjlhJxxgmFMKyLMa7D2B0WHwEI4g4zBmn98fgc4xLCKGgkH8CxxjSUiBORuBhsu5crZrOBKfabOa64JpsvnPa5AvTGhXd-iG78u3exMTJrA9Z92iyyquu33ib_Wy913nl112y6bFJ6Jx1Te93qQbj-AUc2TTM15d5Am5-nV1Xv_OL-fS8mlzkDSWiyHmNGSq4MIQgWyNssaAlUxorQoWwmpZEEw3rBFjEFCoIpJxSQQlFWheCnIDvg-8m-H_b9Ge5crExbavWxm-jFJRjwoqCv80kNCULCUvMYmA2wccYjJWb4FYq7CWCsu9DLmUfu-xjl30f8rkPuUvSby-PbOuV0QfhawGJcDoQ_rvW7N9tLCfzRbokeT7IXWpnd5Cr8FdyQQSTd7OpRFNc3cL7P_KKPAHHc6dy</recordid><startdate>201007</startdate><enddate>201007</enddate><creator>Seabra, Amedea B.</creator><creator>Martins, Dorival</creator><creator>Simões, Maíra M.S.G.</creator><creator>Da Silva, Regiane</creator><creator>Brocchi, Marcelo</creator><creator>De Oliveira, Marcelo G.</creator><general>Blackwell Publishing Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>201007</creationdate><title>Antibacterial Nitric Oxide-Releasing Polyester for the Coating of Blood-Contacting Artificial Materials</title><author>Seabra, Amedea B. ; 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| ispartof | Artificial organs, 2010-07, Vol.34 (7), p.E204-E214 |
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| subjects | Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacology Antibacterial action Biocompatible Materials - chemical synthesis Biocompatible Materials - chemistry Biocompatible Materials - pharmacology Biomaterials Blood-contacting artificial materials Catheter-related infections Catheters, Indwelling Nitric oxide Nitric Oxide - administration & dosage Nitric Oxide - pharmacology Polyesters - chemical synthesis Polyesters - chemistry Polyesters - pharmacology Polymethyl Methacrylate - chemical synthesis Polymethyl Methacrylate - chemistry Polymethyl Methacrylate - pharmacology Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Staphylococcus aureus Staphylococcus aureus - drug effects Sulfhydryl Compounds - chemical synthesis Sulfhydryl Compounds - chemistry Sulfhydryl Compounds - pharmacology |
| title | Antibacterial Nitric Oxide-Releasing Polyester for the Coating of Blood-Contacting Artificial Materials |
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