Reverse engineering the kidney: modelling calcium oxalate monohydrate crystallization in the nephron
Crystallization of calcium oxalate monohydrate in a section of a single kidney nephron (distal convoluted tubule) is simulated using a model adapted from industrial crystallization. The nephron fluid dynamics is represented as a crystallizer/separator series with changing volume to allow for water r...
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| Veröffentlicht in: | Medical & biological engineering & computing 2010-07, Vol.48 (7), p.649-659 |
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| creator | Borissova, A Goltz, G. E Kavanagh, J. P Wilkins, T. A |
| description | Crystallization of calcium oxalate monohydrate in a section of a single kidney nephron (distal convoluted tubule) is simulated using a model adapted from industrial crystallization. The nephron fluid dynamics is represented as a crystallizer/separator series with changing volume to allow for water removal along the tubule. The model integrates crystallization kinetics and crystal size distribution and allows the prediction of the calcium oxalate concentration profile and the nucleation and growth rates. The critical supersaturation ratio for the nucleation of calcium oxalate crystals has been estimated as 2 and the mean crystal size as 1 μm. The crystal growth order, determined as 2.2, indicates a surface integration mechanism of crystal growth and crystal growth dispersion. The model allows the exploration of the effect of varying the input calcium oxalate concentration and the rate of water extraction, simulating real life stressors for stone formation such as dietary loading and dehydration. |
| doi_str_mv | 10.1007/s11517-010-0617-y |
| format | Article |
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The model allows the exploration of the effect of varying the input calcium oxalate concentration and the rate of water extraction, simulating real life stressors for stone formation such as dietary loading and dehydration.</description><identifier>ISSN: 0140-0118</identifier><identifier>EISSN: 1741-0444</identifier><identifier>DOI: 10.1007/s11517-010-0617-y</identifier><identifier>PMID: 20424925</identifier><language>eng</language><publisher>Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag</publisher><subject>Algorithms ; Bioengineering ; Biomedical and Life Sciences ; Biomedical Engineering and Bioengineering ; Biomedicine ; Calcium ; calcium oxalate ; Calcium Oxalate - urine ; Chemical engineering ; Chemical Engineering - methods ; Computer Applications ; Crystallization ; Crystals ; Human Physiology ; Humans ; Hydrodynamics ; Imaging ; Input output ; Kidney Calculi - metabolism ; Kidney diseases ; Kidney stones ; Kidney Tubules, Distal - metabolism ; kidneys ; Models, Biological ; Original Article ; Population balance ; Radiology ; Reverse engineering ; Simulation ; Studies ; Urine</subject><ispartof>Medical & biological engineering & computing, 2010-07, Vol.48 (7), p.649-659</ispartof><rights>International Federation for Medical and Biological Engineering 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-f085db0f17f077e44e859b64a35219d837ed50527e658f1691815bd1da854da3</citedby><cites>FETCH-LOGICAL-c426t-f085db0f17f077e44e859b64a35219d837ed50527e658f1691815bd1da854da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11517-010-0617-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11517-010-0617-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20424925$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Borissova, A</creatorcontrib><creatorcontrib>Goltz, G. E</creatorcontrib><creatorcontrib>Kavanagh, J. P</creatorcontrib><creatorcontrib>Wilkins, T. A</creatorcontrib><title>Reverse engineering the kidney: modelling calcium oxalate monohydrate crystallization in the nephron</title><title>Medical & biological engineering & computing</title><addtitle>Med Biol Eng Comput</addtitle><addtitle>Med Biol Eng Comput</addtitle><description>Crystallization of calcium oxalate monohydrate in a section of a single kidney nephron (distal convoluted tubule) is simulated using a model adapted from industrial crystallization. The nephron fluid dynamics is represented as a crystallizer/separator series with changing volume to allow for water removal along the tubule. The model integrates crystallization kinetics and crystal size distribution and allows the prediction of the calcium oxalate concentration profile and the nucleation and growth rates. The critical supersaturation ratio for the nucleation of calcium oxalate crystals has been estimated as 2 and the mean crystal size as 1 μm. The crystal growth order, determined as 2.2, indicates a surface integration mechanism of crystal growth and crystal growth dispersion. The model allows the exploration of the effect of varying the input calcium oxalate concentration and the rate of water extraction, simulating real life stressors for stone formation such as dietary loading and dehydration.</description><subject>Algorithms</subject><subject>Bioengineering</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedicine</subject><subject>Calcium</subject><subject>calcium oxalate</subject><subject>Calcium Oxalate - urine</subject><subject>Chemical engineering</subject><subject>Chemical Engineering - methods</subject><subject>Computer Applications</subject><subject>Crystallization</subject><subject>Crystals</subject><subject>Human Physiology</subject><subject>Humans</subject><subject>Hydrodynamics</subject><subject>Imaging</subject><subject>Input output</subject><subject>Kidney Calculi - metabolism</subject><subject>Kidney diseases</subject><subject>Kidney stones</subject><subject>Kidney Tubules, Distal - metabolism</subject><subject>kidneys</subject><subject>Models, Biological</subject><subject>Original Article</subject><subject>Population balance</subject><subject>Radiology</subject><subject>Reverse engineering</subject><subject>Simulation</subject><subject>Studies</subject><subject>Urine</subject><issn>0140-0118</issn><issn>1741-0444</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkU1v1DAQhi0EokvhB3CBqBdOgRnHjr3cUFU-pEpIUM6WN57spiT2YieI8OvrkEIlDnDyyPPMO7Yexp4ivEQA9SohSlQlIJRQ52K-xzaoBJYghLjPNoAidxD1CXuU0jUAR8nFQ3bCQXCx5XLD3Cf6TjFRQX7feaLY-X0xHqj42jlP8-tiCI76frltbN9001CEH7a3I-WOD4fZxaVu4pxGm7mfduyCLzr_K8TT8RCDf8wetLZP9OT2PGVXby-uzt-Xlx_ffTh_c1k2gtdj2YKWbgctqhaUIiFIy-2uFraSHLdOV4qcBMkV1VK3WG9Ro9w5dFZL4Wx1yl6ssccYvk2URjN0qcmvt57ClIwSNa8k1Pr_ZFUtO4XK5Nlf5HWYos-_MBIqlELgEocr1MSQUqTWHGM32DgbBLOYMqspk02ZxZSZ88yz2-BpN5D7M_FbTQb4CqTjIoXi3eZ_pT5fh1objN3HLpkvnzlgBahlrVVd3QCz2Kf1</recordid><startdate>20100701</startdate><enddate>20100701</enddate><creator>Borissova, A</creator><creator>Goltz, G. 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E</au><au>Kavanagh, J. P</au><au>Wilkins, T. A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reverse engineering the kidney: modelling calcium oxalate monohydrate crystallization in the nephron</atitle><jtitle>Medical & biological engineering & computing</jtitle><stitle>Med Biol Eng Comput</stitle><addtitle>Med Biol Eng Comput</addtitle><date>2010-07-01</date><risdate>2010</risdate><volume>48</volume><issue>7</issue><spage>649</spage><epage>659</epage><pages>649-659</pages><issn>0140-0118</issn><eissn>1741-0444</eissn><abstract>Crystallization of calcium oxalate monohydrate in a section of a single kidney nephron (distal convoluted tubule) is simulated using a model adapted from industrial crystallization. The nephron fluid dynamics is represented as a crystallizer/separator series with changing volume to allow for water removal along the tubule. The model integrates crystallization kinetics and crystal size distribution and allows the prediction of the calcium oxalate concentration profile and the nucleation and growth rates. The critical supersaturation ratio for the nucleation of calcium oxalate crystals has been estimated as 2 and the mean crystal size as 1 μm. The crystal growth order, determined as 2.2, indicates a surface integration mechanism of crystal growth and crystal growth dispersion. The model allows the exploration of the effect of varying the input calcium oxalate concentration and the rate of water extraction, simulating real life stressors for stone formation such as dietary loading and dehydration.</abstract><cop>Berlin/Heidelberg</cop><pub>Berlin/Heidelberg : Springer-Verlag</pub><pmid>20424925</pmid><doi>10.1007/s11517-010-0617-y</doi><tpages>11</tpages></addata></record> |
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| subjects | Algorithms Bioengineering Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Calcium calcium oxalate Calcium Oxalate - urine Chemical engineering Chemical Engineering - methods Computer Applications Crystallization Crystals Human Physiology Humans Hydrodynamics Imaging Input output Kidney Calculi - metabolism Kidney diseases Kidney stones Kidney Tubules, Distal - metabolism kidneys Models, Biological Original Article Population balance Radiology Reverse engineering Simulation Studies Urine |
| title | Reverse engineering the kidney: modelling calcium oxalate monohydrate crystallization in the nephron |
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