Association between N-terminal pro-brain natriuretic peptide and acute ischemic stroke in patients on chronic hemodialysis
Background Plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) has been reported as a predictor for ischemic stroke in general population. However, predictive value of plasma NT-proBNP for acute ischemic stroke in patients on chronic hemodialysis has not been well established. The aim of thi...
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| Veröffentlicht in: | International urology and nephrology 2010-06, Vol.42 (2), p.537-543 |
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| creator | Kim, Yong Kyun Shin, Seok Joon Ihm, Sang-Hyun Park, Chan Seok Kim, Hee-Yeol Kim, Young-Du Shim, Dong Suk Song, Ho Cheol Yang, Chul Woo Kim, Yong-Soo Choi, Euy Jin |
| description | Background
Plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) has been reported as a predictor for ischemic stroke in general population. However, predictive value of plasma NT-proBNP for acute ischemic stroke in patients on chronic hemodialysis has not been well established. The aim of this study was to determine whether NT-proBNP could predict acute ischemic stroke in patients on chronic hemodialysis.
Methods
This study was designed prospectively. Clinical, laboratory, and echocardiographic variables were assessed in 72 patients on chronic hemodialysis. The plasma levels of NT-proBNP were measured by immunoassay.
Results
During the follow-up period of 45 months, 11 patients had an acute ischemic stroke. The Kaplan–Meier plot showed an increased frequency of acute ischemic stroke in patients with plasma levels of NT-proBNP above the median values compared to patients with lower concentrations (
P
= 0.028). The multivariate Cox proportional hazard models showed that the NT-proBNP was a significant independent predictor of acute ischemic stroke after adjustment for age, sex, mean blood pressure, diabetes, serum cholesterol levels, left ventricular mass index, and left ventricular fractional shortening (HR 6.66, 95% CI, 1.22–36.48,
P
= 0.029).
Conclusions
Our data suggest that plasma NT-proBNP levels predict the risk of acute ischemic stroke in patients on chronic hemodialysis. |
| doi_str_mv | 10.1007/s11255-009-9689-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_746234941</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2223193311</sourcerecordid><originalsourceid>FETCH-LOGICAL-c402t-64cec3e817b2b33bf014b129a746feb3c0fed4cc126b19ceefa7a8eb938c54f13</originalsourceid><addsrcrecordid>eNqNkUuLFTEQRoMoznX0B7iR4MZVNK_uTi-HwRcMutF1SNLVTsbupE3SyPjrrcsdFQTBVQh16lQlHyFPBX8pOB9eVSFk1zHORzb2ZmTmHjmIblBMdkbfJweuuGCil-qMPKr1hiNoOH9IziTnasTeA_lxUWsO0bWYE_XQvgMk-oE1KGtMbqFbycwXFxNNrpW4F2gx0A22FiegLk3Uhb0BjTVcw4ql2kr-ivdEN5RCapWiOVyXnLCKTJ6iW25rrI_Jg9ktFZ7cnefk85vXny7fsauPb99fXlyxoLlsrNcBggIjBi-9Un7mQnshRzfofgavAp9h0iEI2XsxBoDZDc6AH5UJnZ6FOicvTl58y7cdarMrbgvL4hLkvVr0SKVH_R-kUqpTph-QfP4XeZP3gh9WrZG4HA4_6sQJCiXXWmC2W4mrK7dWcHsM0J4CtJiLPQZoDfY8uxPvfoXpd8evxBCQJ6BiKX2B8mfyv60_ASzbqFs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>821299381</pqid></control><display><type>article</type><title>Association between N-terminal pro-brain natriuretic peptide and acute ischemic stroke in patients on chronic hemodialysis</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Kim, Yong Kyun ; Shin, Seok Joon ; Ihm, Sang-Hyun ; Park, Chan Seok ; Kim, Hee-Yeol ; Kim, Young-Du ; Shim, Dong Suk ; Song, Ho Cheol ; Yang, Chul Woo ; Kim, Yong-Soo ; Choi, Euy Jin</creator><creatorcontrib>Kim, Yong Kyun ; Shin, Seok Joon ; Ihm, Sang-Hyun ; Park, Chan Seok ; Kim, Hee-Yeol ; Kim, Young-Du ; Shim, Dong Suk ; Song, Ho Cheol ; Yang, Chul Woo ; Kim, Yong-Soo ; Choi, Euy Jin</creatorcontrib><description>Background
Plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) has been reported as a predictor for ischemic stroke in general population. However, predictive value of plasma NT-proBNP for acute ischemic stroke in patients on chronic hemodialysis has not been well established. The aim of this study was to determine whether NT-proBNP could predict acute ischemic stroke in patients on chronic hemodialysis.
Methods
This study was designed prospectively. Clinical, laboratory, and echocardiographic variables were assessed in 72 patients on chronic hemodialysis. The plasma levels of NT-proBNP were measured by immunoassay.
Results
During the follow-up period of 45 months, 11 patients had an acute ischemic stroke. The Kaplan–Meier plot showed an increased frequency of acute ischemic stroke in patients with plasma levels of NT-proBNP above the median values compared to patients with lower concentrations (
P
= 0.028). The multivariate Cox proportional hazard models showed that the NT-proBNP was a significant independent predictor of acute ischemic stroke after adjustment for age, sex, mean blood pressure, diabetes, serum cholesterol levels, left ventricular mass index, and left ventricular fractional shortening (HR 6.66, 95% CI, 1.22–36.48,
P
= 0.029).
Conclusions
Our data suggest that plasma NT-proBNP levels predict the risk of acute ischemic stroke in patients on chronic hemodialysis.</description><identifier>ISSN: 0301-1623</identifier><identifier>EISSN: 1573-2584</identifier><identifier>DOI: 10.1007/s11255-009-9689-8</identifier><identifier>PMID: 20039125</identifier><identifier>CODEN: IURNAE</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Acute Disease ; Brain Ischemia - epidemiology ; Female ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Natriuretic Peptide, Brain - blood ; Nephrology ; Nephrology - Original Paper ; Peptide Fragments - blood ; Predictive Value of Tests ; Prospective Studies ; Renal Dialysis ; Risk Factors ; Stroke - epidemiology ; Urology</subject><ispartof>International urology and nephrology, 2010-06, Vol.42 (2), p.537-543</ispartof><rights>Springer Science+Business Media, B.V. 2009</rights><rights>Springer Science+Business Media, B.V. 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-64cec3e817b2b33bf014b129a746feb3c0fed4cc126b19ceefa7a8eb938c54f13</citedby><cites>FETCH-LOGICAL-c402t-64cec3e817b2b33bf014b129a746feb3c0fed4cc126b19ceefa7a8eb938c54f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11255-009-9689-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11255-009-9689-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20039125$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Yong Kyun</creatorcontrib><creatorcontrib>Shin, Seok Joon</creatorcontrib><creatorcontrib>Ihm, Sang-Hyun</creatorcontrib><creatorcontrib>Park, Chan Seok</creatorcontrib><creatorcontrib>Kim, Hee-Yeol</creatorcontrib><creatorcontrib>Kim, Young-Du</creatorcontrib><creatorcontrib>Shim, Dong Suk</creatorcontrib><creatorcontrib>Song, Ho Cheol</creatorcontrib><creatorcontrib>Yang, Chul Woo</creatorcontrib><creatorcontrib>Kim, Yong-Soo</creatorcontrib><creatorcontrib>Choi, Euy Jin</creatorcontrib><title>Association between N-terminal pro-brain natriuretic peptide and acute ischemic stroke in patients on chronic hemodialysis</title><title>International urology and nephrology</title><addtitle>Int Urol Nephrol</addtitle><addtitle>Int Urol Nephrol</addtitle><description>Background
Plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) has been reported as a predictor for ischemic stroke in general population. However, predictive value of plasma NT-proBNP for acute ischemic stroke in patients on chronic hemodialysis has not been well established. The aim of this study was to determine whether NT-proBNP could predict acute ischemic stroke in patients on chronic hemodialysis.
Methods
This study was designed prospectively. Clinical, laboratory, and echocardiographic variables were assessed in 72 patients on chronic hemodialysis. The plasma levels of NT-proBNP were measured by immunoassay.
Results
During the follow-up period of 45 months, 11 patients had an acute ischemic stroke. The Kaplan–Meier plot showed an increased frequency of acute ischemic stroke in patients with plasma levels of NT-proBNP above the median values compared to patients with lower concentrations (
P
= 0.028). The multivariate Cox proportional hazard models showed that the NT-proBNP was a significant independent predictor of acute ischemic stroke after adjustment for age, sex, mean blood pressure, diabetes, serum cholesterol levels, left ventricular mass index, and left ventricular fractional shortening (HR 6.66, 95% CI, 1.22–36.48,
P
= 0.029).
Conclusions
Our data suggest that plasma NT-proBNP levels predict the risk of acute ischemic stroke in patients on chronic hemodialysis.</description><subject>Acute Disease</subject><subject>Brain Ischemia - epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Natriuretic Peptide, Brain - blood</subject><subject>Nephrology</subject><subject>Nephrology - Original Paper</subject><subject>Peptide Fragments - blood</subject><subject>Predictive Value of Tests</subject><subject>Prospective Studies</subject><subject>Renal Dialysis</subject><subject>Risk Factors</subject><subject>Stroke - epidemiology</subject><subject>Urology</subject><issn>0301-1623</issn><issn>1573-2584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkUuLFTEQRoMoznX0B7iR4MZVNK_uTi-HwRcMutF1SNLVTsbupE3SyPjrrcsdFQTBVQh16lQlHyFPBX8pOB9eVSFk1zHORzb2ZmTmHjmIblBMdkbfJweuuGCil-qMPKr1hiNoOH9IziTnasTeA_lxUWsO0bWYE_XQvgMk-oE1KGtMbqFbycwXFxNNrpW4F2gx0A22FiegLk3Uhb0BjTVcw4ql2kr-ivdEN5RCapWiOVyXnLCKTJ6iW25rrI_Jg9ktFZ7cnefk85vXny7fsauPb99fXlyxoLlsrNcBggIjBi-9Un7mQnshRzfofgavAp9h0iEI2XsxBoDZDc6AH5UJnZ6FOicvTl58y7cdarMrbgvL4hLkvVr0SKVH_R-kUqpTph-QfP4XeZP3gh9WrZG4HA4_6sQJCiXXWmC2W4mrK7dWcHsM0J4CtJiLPQZoDfY8uxPvfoXpd8evxBCQJ6BiKX2B8mfyv60_ASzbqFs</recordid><startdate>20100601</startdate><enddate>20100601</enddate><creator>Kim, Yong Kyun</creator><creator>Shin, Seok Joon</creator><creator>Ihm, Sang-Hyun</creator><creator>Park, Chan Seok</creator><creator>Kim, Hee-Yeol</creator><creator>Kim, Young-Du</creator><creator>Shim, Dong Suk</creator><creator>Song, Ho Cheol</creator><creator>Yang, Chul Woo</creator><creator>Kim, Yong-Soo</creator><creator>Choi, Euy Jin</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20100601</creationdate><title>Association between N-terminal pro-brain natriuretic peptide and acute ischemic stroke in patients on chronic hemodialysis</title><author>Kim, Yong Kyun ; Shin, Seok Joon ; Ihm, Sang-Hyun ; Park, Chan Seok ; Kim, Hee-Yeol ; Kim, Young-Du ; Shim, Dong Suk ; Song, Ho Cheol ; Yang, Chul Woo ; Kim, Yong-Soo ; Choi, Euy Jin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-64cec3e817b2b33bf014b129a746feb3c0fed4cc126b19ceefa7a8eb938c54f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Acute Disease</topic><topic>Brain Ischemia - epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Natriuretic Peptide, Brain - blood</topic><topic>Nephrology</topic><topic>Nephrology - Original Paper</topic><topic>Peptide Fragments - blood</topic><topic>Predictive Value of Tests</topic><topic>Prospective Studies</topic><topic>Renal Dialysis</topic><topic>Risk Factors</topic><topic>Stroke - epidemiology</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Yong Kyun</creatorcontrib><creatorcontrib>Shin, Seok Joon</creatorcontrib><creatorcontrib>Ihm, Sang-Hyun</creatorcontrib><creatorcontrib>Park, Chan Seok</creatorcontrib><creatorcontrib>Kim, Hee-Yeol</creatorcontrib><creatorcontrib>Kim, Young-Du</creatorcontrib><creatorcontrib>Shim, Dong Suk</creatorcontrib><creatorcontrib>Song, Ho Cheol</creatorcontrib><creatorcontrib>Yang, Chul Woo</creatorcontrib><creatorcontrib>Kim, Yong-Soo</creatorcontrib><creatorcontrib>Choi, Euy Jin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>International urology and nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Yong Kyun</au><au>Shin, Seok Joon</au><au>Ihm, Sang-Hyun</au><au>Park, Chan Seok</au><au>Kim, Hee-Yeol</au><au>Kim, Young-Du</au><au>Shim, Dong Suk</au><au>Song, Ho Cheol</au><au>Yang, Chul Woo</au><au>Kim, Yong-Soo</au><au>Choi, Euy Jin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between N-terminal pro-brain natriuretic peptide and acute ischemic stroke in patients on chronic hemodialysis</atitle><jtitle>International urology and nephrology</jtitle><stitle>Int Urol Nephrol</stitle><addtitle>Int Urol Nephrol</addtitle><date>2010-06-01</date><risdate>2010</risdate><volume>42</volume><issue>2</issue><spage>537</spage><epage>543</epage><pages>537-543</pages><issn>0301-1623</issn><eissn>1573-2584</eissn><coden>IURNAE</coden><abstract>Background
Plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) has been reported as a predictor for ischemic stroke in general population. However, predictive value of plasma NT-proBNP for acute ischemic stroke in patients on chronic hemodialysis has not been well established. The aim of this study was to determine whether NT-proBNP could predict acute ischemic stroke in patients on chronic hemodialysis.
Methods
This study was designed prospectively. Clinical, laboratory, and echocardiographic variables were assessed in 72 patients on chronic hemodialysis. The plasma levels of NT-proBNP were measured by immunoassay.
Results
During the follow-up period of 45 months, 11 patients had an acute ischemic stroke. The Kaplan–Meier plot showed an increased frequency of acute ischemic stroke in patients with plasma levels of NT-proBNP above the median values compared to patients with lower concentrations (
P
= 0.028). The multivariate Cox proportional hazard models showed that the NT-proBNP was a significant independent predictor of acute ischemic stroke after adjustment for age, sex, mean blood pressure, diabetes, serum cholesterol levels, left ventricular mass index, and left ventricular fractional shortening (HR 6.66, 95% CI, 1.22–36.48,
P
= 0.029).
Conclusions
Our data suggest that plasma NT-proBNP levels predict the risk of acute ischemic stroke in patients on chronic hemodialysis.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>20039125</pmid><doi>10.1007/s11255-009-9689-8</doi><tpages>7</tpages></addata></record> |
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| subjects | Acute Disease Brain Ischemia - epidemiology Female Humans Male Medicine Medicine & Public Health Middle Aged Natriuretic Peptide, Brain - blood Nephrology Nephrology - Original Paper Peptide Fragments - blood Predictive Value of Tests Prospective Studies Renal Dialysis Risk Factors Stroke - epidemiology Urology |
| title | Association between N-terminal pro-brain natriuretic peptide and acute ischemic stroke in patients on chronic hemodialysis |
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