Systemic leukocyte filtration during cardiopulmonary bypass
Cardiopulmonary bypass (CPB) induces a whole body inflammatory response leading to postoperative lung dysfunction. Activated leukocytes may play a role in the pathogenesis of pulmonary dysfunction. We evaluated postoperative lung function after the use of leukocyte-depleting filters incorporated in...
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| Veröffentlicht in: | Perfusion 2001, Vol.16 (1_suppl), p.11-18 |
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| description | Cardiopulmonary bypass (CPB) induces a whole body inflammatory response leading to
postoperative lung dysfunction. Activated leukocytes may play a role in the
pathogenesis of pulmonary dysfunction. We evaluated postoperative lung function
after the use of leukocyte-depleting filters incorporated in the extracorporeal
circuit during CPB.From November 1997 to March 2000, 40 patients underwent isolated coronary artery
bypass grafting. Patients were randomly allocated to the leukocyte-depletion group
(group F, 20 patients) or to the control group (group C, 20 patients).There was no significant difference between the two groups with respect to age, sex,
weight, height, body surface area, haemoglobin and haematocrit levels, preoperative
left ventricular ejection fraction, cooling temperature, aortic crossclamping and
CBP duration. Blood samples were drawn preoperatively, at aortic declamping, 60 min
after CPB, after arriving at the intensive care unit (ICU) and 24 h after the
operation. We analysed blood cell count, elastase, interleukin-8 (IL-8) and tumour
necrosis factor (TNF-α) levels and continuous monitoring of arterial blood
gases in the intensive care unit (ICU).The analysis of total circulating white blood cells (WBCs) showed a significant
reduction of WBCs in both groups soon after aortic declamping [from the right
atrium: 6.4 109/l ± 1.4×109/l in group F
vs 10.3 ± 1.8×109/l in group C
(p |
| doi_str_mv | 10.1177/026765910101600i103 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_746232798</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_026765910101600i103</sage_id><sourcerecordid>1082158561</sourcerecordid><originalsourceid>FETCH-LOGICAL-c429t-14e9b55731329bda523586afdf0366c9953c54dcf3253f0e2d7cc94b8573d7283</originalsourceid><addsrcrecordid>eNp90ctKxDAYBeAgijOOPoEgRUFX1dzT4EoGbzDgQgV3JU3TIWNvJu2ib2_qDCiiQxbZfOfk8gNwjOAlQkJcQcwFZxLBsDiEFkGyA6aIChEjhN52wXQU8Ugm4MD7FYSQUkr2wQQhQiiGeAqunwffmcrqqDT9e6OHzkSFLTunOtvUUd47Wy8jrVxum7Yvq6ZWboiyoVXeH4K9QpXeHG32GXi9u32ZP8SLp_vH-c0i1hTLLkbUyIwxQRDBMssVw4QlXBV5AQnnWkpGNKO5LghmpIAG50JrSbMkRHKBEzIDF-ve1jUfvfFdWlmvTVmq2jS9TwXlmGAhR3m-XcIEU8pJgKe_4KrpXR1ekaJwISbxFzr7FyUJ4wlNEA-KrJV2jffOFGnrbBV-KUUwHQeV_jGokDrZdPdZZfLvzGYyAcA18Gppfhy8pfMTfWKZgw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>199559263</pqid></control><display><type>article</type><title>Systemic leukocyte filtration during cardiopulmonary bypass</title><source>MEDLINE</source><source>SAGE Complete A-Z List</source><creator>Fabbri, Alessandro ; Manfredi, Jacopo ; Piccin, Caterina ; Soffiati, Giuliano ; Carta, Maria Rosa ; Gasparotto, Edoardo ; Nardon, Giuseppe</creator><creatorcontrib>Fabbri, Alessandro ; Manfredi, Jacopo ; Piccin, Caterina ; Soffiati, Giuliano ; Carta, Maria Rosa ; Gasparotto, Edoardo ; Nardon, Giuseppe</creatorcontrib><description>Cardiopulmonary bypass (CPB) induces a whole body inflammatory response leading to
postoperative lung dysfunction. Activated leukocytes may play a role in the
pathogenesis of pulmonary dysfunction. We evaluated postoperative lung function
after the use of leukocyte-depleting filters incorporated in the extracorporeal
circuit during CPB.From November 1997 to March 2000, 40 patients underwent isolated coronary artery
bypass grafting. Patients were randomly allocated to the leukocyte-depletion group
(group F, 20 patients) or to the control group (group C, 20 patients).There was no significant difference between the two groups with respect to age, sex,
weight, height, body surface area, haemoglobin and haematocrit levels, preoperative
left ventricular ejection fraction, cooling temperature, aortic crossclamping and
CBP duration. Blood samples were drawn preoperatively, at aortic declamping, 60 min
after CPB, after arriving at the intensive care unit (ICU) and 24 h after the
operation. We analysed blood cell count, elastase, interleukin-8 (IL-8) and tumour
necrosis factor (TNF-α) levels and continuous monitoring of arterial blood
gases in the intensive care unit (ICU).The analysis of total circulating white blood cells (WBCs) showed a significant
reduction of WBCs in both groups soon after aortic declamping [from the right
atrium: 6.4 109/l ± 1.4×109/l in group F
vs 10.3 ± 1.8×109/l in group C
(p<0.05); from the left atrium: 5.8 ±
1.3×109/l in group F vs 8.4 ±
1.9×109/l in group C (p<0.05)] and after 60 min
of CPB [7.1 ± 2.2×109/l in group F vs 10.4
± 1.8×109/l in group C (p<0.05)].The analysis of circulating neutrophils showed similar findings in both groups.Elastase levels increased during CPB in both groups with a peak at the end of CPB
without significant difference between the two groups (group C: 260 ± 148
μg/l vs group F: 371 ± 68 μg/l). The decrease of
plasmatic elestase levels was observed, for both groups, in the 24 h after CPB.There was no difference in intubation time between the two groups (16.4 h for group C
vs 11.2 h for group F).Pulmonary function tested by pulmonary respiratory index [RI = partial pressure of
oxygen/fraction of inspired oxygen (PaO2/FiO2 x 100)] did not
show significant difference between the two groups, either arriving in the ICU
(group C RI 265 vs group F RI 322), or after 3 h (group RI 304 vs group F RI 305) or
after 6 h (group C RI 292 vs group F RI 319).Leukocyte-depleting filters reduce with blood cells count during CPB, but, in this
study, WBC depletion did not significantly improve clinical conditions or laboratory finding.</description><identifier>ISSN: 0267-6591</identifier><identifier>EISSN: 1477-111X</identifier><identifier>DOI: 10.1177/026765910101600i103</identifier><identifier>PMID: 11334202</identifier><language>eng</language><publisher>Thousand Oaks, CA: SAGE Publications</publisher><subject>Aged ; Aorta ; Atrium ; Blood ; Blood circulation ; Bypasses ; Cardiopulmonary Bypass - adverse effects ; Cardiopulmonary Bypass - methods ; Cooling ; Coronary artery ; Depletion ; Elastase ; Female ; Filters ; Filtration ; Gases ; Heart ; Heart surgery ; Hematocrit ; Hemoglobin ; Humans ; Inflammation ; Inflammation - etiology ; Inflammation - prevention & control ; Inflammatory response ; Intensive care ; Interleukin 8 ; Interleukins ; Intubation ; Leukapheresis ; Leukocyte Count ; Leukocytes ; Leukocytes (neutrophilic) ; Lungs ; Male ; Middle Aged ; Neutrophils - cytology ; Oxygen ; Pancreatic Elastase - blood ; Partial pressure ; Pathogenesis ; Patients ; Respiratory function ; Respiratory Function Tests ; Temperature effects ; Time Factors ; Tumor necrosis factor ; Tumor necrosis factor-TNF ; Tumors ; Ventricle</subject><ispartof>Perfusion, 2001, Vol.16 (1_suppl), p.11-18</ispartof><rights>Copyright Sage Publications Ltd. Jan 2001</rights><rights>2001 SAGE Publications</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-14e9b55731329bda523586afdf0366c9953c54dcf3253f0e2d7cc94b8573d7283</citedby><cites>FETCH-LOGICAL-c429t-14e9b55731329bda523586afdf0366c9953c54dcf3253f0e2d7cc94b8573d7283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/026765910101600i103$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/026765910101600i103$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,4024,21819,27923,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11334202$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fabbri, Alessandro</creatorcontrib><creatorcontrib>Manfredi, Jacopo</creatorcontrib><creatorcontrib>Piccin, Caterina</creatorcontrib><creatorcontrib>Soffiati, Giuliano</creatorcontrib><creatorcontrib>Carta, Maria Rosa</creatorcontrib><creatorcontrib>Gasparotto, Edoardo</creatorcontrib><creatorcontrib>Nardon, Giuseppe</creatorcontrib><title>Systemic leukocyte filtration during cardiopulmonary bypass</title><title>Perfusion</title><addtitle>Perfusion</addtitle><description>Cardiopulmonary bypass (CPB) induces a whole body inflammatory response leading to
postoperative lung dysfunction. Activated leukocytes may play a role in the
pathogenesis of pulmonary dysfunction. We evaluated postoperative lung function
after the use of leukocyte-depleting filters incorporated in the extracorporeal
circuit during CPB.From November 1997 to March 2000, 40 patients underwent isolated coronary artery
bypass grafting. Patients were randomly allocated to the leukocyte-depletion group
(group F, 20 patients) or to the control group (group C, 20 patients).There was no significant difference between the two groups with respect to age, sex,
weight, height, body surface area, haemoglobin and haematocrit levels, preoperative
left ventricular ejection fraction, cooling temperature, aortic crossclamping and
CBP duration. Blood samples were drawn preoperatively, at aortic declamping, 60 min
after CPB, after arriving at the intensive care unit (ICU) and 24 h after the
operation. We analysed blood cell count, elastase, interleukin-8 (IL-8) and tumour
necrosis factor (TNF-α) levels and continuous monitoring of arterial blood
gases in the intensive care unit (ICU).The analysis of total circulating white blood cells (WBCs) showed a significant
reduction of WBCs in both groups soon after aortic declamping [from the right
atrium: 6.4 109/l ± 1.4×109/l in group F
vs 10.3 ± 1.8×109/l in group C
(p<0.05); from the left atrium: 5.8 ±
1.3×109/l in group F vs 8.4 ±
1.9×109/l in group C (p<0.05)] and after 60 min
of CPB [7.1 ± 2.2×109/l in group F vs 10.4
± 1.8×109/l in group C (p<0.05)].The analysis of circulating neutrophils showed similar findings in both groups.Elastase levels increased during CPB in both groups with a peak at the end of CPB
without significant difference between the two groups (group C: 260 ± 148
μg/l vs group F: 371 ± 68 μg/l). The decrease of
plasmatic elestase levels was observed, for both groups, in the 24 h after CPB.There was no difference in intubation time between the two groups (16.4 h for group C
vs 11.2 h for group F).Pulmonary function tested by pulmonary respiratory index [RI = partial pressure of
oxygen/fraction of inspired oxygen (PaO2/FiO2 x 100)] did not
show significant difference between the two groups, either arriving in the ICU
(group C RI 265 vs group F RI 322), or after 3 h (group RI 304 vs group F RI 305) or
after 6 h (group C RI 292 vs group F RI 319).Leukocyte-depleting filters reduce with blood cells count during CPB, but, in this
study, WBC depletion did not significantly improve clinical conditions or laboratory finding.</description><subject>Aged</subject><subject>Aorta</subject><subject>Atrium</subject><subject>Blood</subject><subject>Blood circulation</subject><subject>Bypasses</subject><subject>Cardiopulmonary Bypass - adverse effects</subject><subject>Cardiopulmonary Bypass - methods</subject><subject>Cooling</subject><subject>Coronary artery</subject><subject>Depletion</subject><subject>Elastase</subject><subject>Female</subject><subject>Filters</subject><subject>Filtration</subject><subject>Gases</subject><subject>Heart</subject><subject>Heart surgery</subject><subject>Hematocrit</subject><subject>Hemoglobin</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation - etiology</subject><subject>Inflammation - prevention & control</subject><subject>Inflammatory response</subject><subject>Intensive care</subject><subject>Interleukin 8</subject><subject>Interleukins</subject><subject>Intubation</subject><subject>Leukapheresis</subject><subject>Leukocyte Count</subject><subject>Leukocytes</subject><subject>Leukocytes (neutrophilic)</subject><subject>Lungs</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neutrophils - cytology</subject><subject>Oxygen</subject><subject>Pancreatic Elastase - blood</subject><subject>Partial pressure</subject><subject>Pathogenesis</subject><subject>Patients</subject><subject>Respiratory function</subject><subject>Respiratory Function Tests</subject><subject>Temperature effects</subject><subject>Time Factors</subject><subject>Tumor necrosis factor</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumors</subject><subject>Ventricle</subject><issn>0267-6591</issn><issn>1477-111X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp90ctKxDAYBeAgijOOPoEgRUFX1dzT4EoGbzDgQgV3JU3TIWNvJu2ib2_qDCiiQxbZfOfk8gNwjOAlQkJcQcwFZxLBsDiEFkGyA6aIChEjhN52wXQU8Ugm4MD7FYSQUkr2wQQhQiiGeAqunwffmcrqqDT9e6OHzkSFLTunOtvUUd47Wy8jrVxum7Yvq6ZWboiyoVXeH4K9QpXeHG32GXi9u32ZP8SLp_vH-c0i1hTLLkbUyIwxQRDBMssVw4QlXBV5AQnnWkpGNKO5LghmpIAG50JrSbMkRHKBEzIDF-ve1jUfvfFdWlmvTVmq2jS9TwXlmGAhR3m-XcIEU8pJgKe_4KrpXR1ekaJwISbxFzr7FyUJ4wlNEA-KrJV2jffOFGnrbBV-KUUwHQeV_jGokDrZdPdZZfLvzGYyAcA18Gppfhy8pfMTfWKZgw</recordid><startdate>2001</startdate><enddate>2001</enddate><creator>Fabbri, Alessandro</creator><creator>Manfredi, Jacopo</creator><creator>Piccin, Caterina</creator><creator>Soffiati, Giuliano</creator><creator>Carta, Maria Rosa</creator><creator>Gasparotto, Edoardo</creator><creator>Nardon, Giuseppe</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>2001</creationdate><title>Systemic leukocyte filtration during cardiopulmonary bypass</title><author>Fabbri, Alessandro ; Manfredi, Jacopo ; Piccin, Caterina ; Soffiati, Giuliano ; Carta, Maria Rosa ; Gasparotto, Edoardo ; Nardon, Giuseppe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-14e9b55731329bda523586afdf0366c9953c54dcf3253f0e2d7cc94b8573d7283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Aged</topic><topic>Aorta</topic><topic>Atrium</topic><topic>Blood</topic><topic>Blood circulation</topic><topic>Bypasses</topic><topic>Cardiopulmonary Bypass - adverse effects</topic><topic>Cardiopulmonary Bypass - methods</topic><topic>Cooling</topic><topic>Coronary artery</topic><topic>Depletion</topic><topic>Elastase</topic><topic>Female</topic><topic>Filters</topic><topic>Filtration</topic><topic>Gases</topic><topic>Heart</topic><topic>Heart surgery</topic><topic>Hematocrit</topic><topic>Hemoglobin</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammation - etiology</topic><topic>Inflammation - prevention & control</topic><topic>Inflammatory response</topic><topic>Intensive care</topic><topic>Interleukin 8</topic><topic>Interleukins</topic><topic>Intubation</topic><topic>Leukapheresis</topic><topic>Leukocyte Count</topic><topic>Leukocytes</topic><topic>Leukocytes (neutrophilic)</topic><topic>Lungs</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neutrophils - cytology</topic><topic>Oxygen</topic><topic>Pancreatic Elastase - blood</topic><topic>Partial pressure</topic><topic>Pathogenesis</topic><topic>Patients</topic><topic>Respiratory function</topic><topic>Respiratory Function Tests</topic><topic>Temperature effects</topic><topic>Time Factors</topic><topic>Tumor necrosis factor</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumors</topic><topic>Ventricle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fabbri, Alessandro</creatorcontrib><creatorcontrib>Manfredi, Jacopo</creatorcontrib><creatorcontrib>Piccin, Caterina</creatorcontrib><creatorcontrib>Soffiati, Giuliano</creatorcontrib><creatorcontrib>Carta, Maria Rosa</creatorcontrib><creatorcontrib>Gasparotto, Edoardo</creatorcontrib><creatorcontrib>Nardon, Giuseppe</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Perfusion</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fabbri, Alessandro</au><au>Manfredi, Jacopo</au><au>Piccin, Caterina</au><au>Soffiati, Giuliano</au><au>Carta, Maria Rosa</au><au>Gasparotto, Edoardo</au><au>Nardon, Giuseppe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Systemic leukocyte filtration during cardiopulmonary bypass</atitle><jtitle>Perfusion</jtitle><addtitle>Perfusion</addtitle><date>2001</date><risdate>2001</risdate><volume>16</volume><issue>1_suppl</issue><spage>11</spage><epage>18</epage><pages>11-18</pages><issn>0267-6591</issn><eissn>1477-111X</eissn><abstract>Cardiopulmonary bypass (CPB) induces a whole body inflammatory response leading to
postoperative lung dysfunction. Activated leukocytes may play a role in the
pathogenesis of pulmonary dysfunction. We evaluated postoperative lung function
after the use of leukocyte-depleting filters incorporated in the extracorporeal
circuit during CPB.From November 1997 to March 2000, 40 patients underwent isolated coronary artery
bypass grafting. Patients were randomly allocated to the leukocyte-depletion group
(group F, 20 patients) or to the control group (group C, 20 patients).There was no significant difference between the two groups with respect to age, sex,
weight, height, body surface area, haemoglobin and haematocrit levels, preoperative
left ventricular ejection fraction, cooling temperature, aortic crossclamping and
CBP duration. Blood samples were drawn preoperatively, at aortic declamping, 60 min
after CPB, after arriving at the intensive care unit (ICU) and 24 h after the
operation. We analysed blood cell count, elastase, interleukin-8 (IL-8) and tumour
necrosis factor (TNF-α) levels and continuous monitoring of arterial blood
gases in the intensive care unit (ICU).The analysis of total circulating white blood cells (WBCs) showed a significant
reduction of WBCs in both groups soon after aortic declamping [from the right
atrium: 6.4 109/l ± 1.4×109/l in group F
vs 10.3 ± 1.8×109/l in group C
(p<0.05); from the left atrium: 5.8 ±
1.3×109/l in group F vs 8.4 ±
1.9×109/l in group C (p<0.05)] and after 60 min
of CPB [7.1 ± 2.2×109/l in group F vs 10.4
± 1.8×109/l in group C (p<0.05)].The analysis of circulating neutrophils showed similar findings in both groups.Elastase levels increased during CPB in both groups with a peak at the end of CPB
without significant difference between the two groups (group C: 260 ± 148
μg/l vs group F: 371 ± 68 μg/l). The decrease of
plasmatic elestase levels was observed, for both groups, in the 24 h after CPB.There was no difference in intubation time between the two groups (16.4 h for group C
vs 11.2 h for group F).Pulmonary function tested by pulmonary respiratory index [RI = partial pressure of
oxygen/fraction of inspired oxygen (PaO2/FiO2 x 100)] did not
show significant difference between the two groups, either arriving in the ICU
(group C RI 265 vs group F RI 322), or after 3 h (group RI 304 vs group F RI 305) or
after 6 h (group C RI 292 vs group F RI 319).Leukocyte-depleting filters reduce with blood cells count during CPB, but, in this
study, WBC depletion did not significantly improve clinical conditions or laboratory finding.</abstract><cop>Thousand Oaks, CA</cop><pub>SAGE Publications</pub><pmid>11334202</pmid><doi>10.1177/026765910101600i103</doi><tpages>8</tpages></addata></record> |
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| ispartof | Perfusion, 2001, Vol.16 (1_suppl), p.11-18 |
| issn | 0267-6591 1477-111X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_746232798 |
| source | MEDLINE; SAGE Complete A-Z List |
| subjects | Aged Aorta Atrium Blood Blood circulation Bypasses Cardiopulmonary Bypass - adverse effects Cardiopulmonary Bypass - methods Cooling Coronary artery Depletion Elastase Female Filters Filtration Gases Heart Heart surgery Hematocrit Hemoglobin Humans Inflammation Inflammation - etiology Inflammation - prevention & control Inflammatory response Intensive care Interleukin 8 Interleukins Intubation Leukapheresis Leukocyte Count Leukocytes Leukocytes (neutrophilic) Lungs Male Middle Aged Neutrophils - cytology Oxygen Pancreatic Elastase - blood Partial pressure Pathogenesis Patients Respiratory function Respiratory Function Tests Temperature effects Time Factors Tumor necrosis factor Tumor necrosis factor-TNF Tumors Ventricle |
| title | Systemic leukocyte filtration during cardiopulmonary bypass |
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