Aberrant Expression of CD8 in B-Cell Non-Hodgkin Lymphoma: A Multicenter Study of 951 Bone Marrow Samples With Lymphomatous Infiltration
T-cell antigen expression can be observed in B-cell non-Hodgkin lymphoma (B-NHL). Although CD5 is expressed in B-cell chronic lymphocytic leukemia (B-CLL) and mantle cell lymphoma, the presence of other T-cell antigens is less common. This article reports a retrospective multicenter analysis in whic...
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| Veröffentlicht in: | American journal of clinical pathology 2009-08, Vol.132 (2), p.186-190 |
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| creator | CARULLI, Giovanni STACCHINI, Alessandra CALLEGARI, Tiziana PETRINI, Mario MARINI, Alessandra MATILDE CIRIELLO, Maria ZUCCA, Alessandra CANNIZZO, Elisa ALIBERTI, Sabrina DEMURTAS, Anna NOVERO, Domenico CALCAGNO, Lara |
| description | T-cell antigen expression can be observed in B-cell non-Hodgkin lymphoma (B-NHL). Although CD5 is expressed in B-cell chronic lymphocytic leukemia (B-CLL) and mantle cell lymphoma, the presence of other T-cell antigens is less common. This article reports a retrospective multicenter analysis in which flow cytometry was used to evaluate aberrant CD8 expression on the pathologic B cells of 951 bone marrow samples from patients with various types of B-NHL. In a total of 18 patients, CD8 was coexpressed: 10 had B-CLL; 1, small lymphocytic lymphoma (SLL); 1, marginal zone lymphoma; 1, lymphoplasmacytic lymphoma; 2, diffuse large B-cell lymphoma; and 3, follicular lymphoma. There was a 1.89% overall frequency of CD8 coexpression in which B-CLL/SLL had a higher frequency (3.03%) than did the other B-cell neoplasms (1.18%). Most cases were characterized by a favorable outcome. |
| doi_str_mv | 10.1309/AJCPNCOHS92ARWRQ |
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Although CD5 is expressed in B-cell chronic lymphocytic leukemia (B-CLL) and mantle cell lymphoma, the presence of other T-cell antigens is less common. This article reports a retrospective multicenter analysis in which flow cytometry was used to evaluate aberrant CD8 expression on the pathologic B cells of 951 bone marrow samples from patients with various types of B-NHL. In a total of 18 patients, CD8 was coexpressed: 10 had B-CLL; 1, small lymphocytic lymphoma (SLL); 1, marginal zone lymphoma; 1, lymphoplasmacytic lymphoma; 2, diffuse large B-cell lymphoma; and 3, follicular lymphoma. There was a 1.89% overall frequency of CD8 coexpression in which B-CLL/SLL had a higher frequency (3.03%) than did the other B-cell neoplasms (1.18%). Most cases were characterized by a favorable outcome.</description><identifier>ISSN: 0002-9173</identifier><identifier>EISSN: 1943-7722</identifier><identifier>DOI: 10.1309/AJCPNCOHS92ARWRQ</identifier><identifier>PMID: 19605812</identifier><identifier>CODEN: AJCPAI</identifier><language>eng</language><publisher>Chicago, IL: American Society of Clinical Pathologists</publisher><subject>Antigens, CD19 - biosynthesis ; Biological and medical sciences ; Biomarkers, Tumor - analysis ; Bone Marrow - metabolism ; Bone Marrow - pathology ; CD5 Antigens - biosynthesis ; CD8 Antigens - biosynthesis ; Flow Cytometry ; Hematologic and hematopoietic diseases ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphoma, B-Cell - metabolism ; Lymphoma, B-Cell - pathology ; Medical sciences ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Retrospective Studies</subject><ispartof>American journal of clinical pathology, 2009-08, Vol.132 (2), p.186-190</ispartof><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21824328$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19605812$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CARULLI, Giovanni</creatorcontrib><creatorcontrib>STACCHINI, Alessandra</creatorcontrib><creatorcontrib>CALLEGARI, Tiziana</creatorcontrib><creatorcontrib>PETRINI, Mario</creatorcontrib><creatorcontrib>MARINI, Alessandra</creatorcontrib><creatorcontrib>MATILDE CIRIELLO, Maria</creatorcontrib><creatorcontrib>ZUCCA, Alessandra</creatorcontrib><creatorcontrib>CANNIZZO, Elisa</creatorcontrib><creatorcontrib>ALIBERTI, Sabrina</creatorcontrib><creatorcontrib>DEMURTAS, Anna</creatorcontrib><creatorcontrib>NOVERO, Domenico</creatorcontrib><creatorcontrib>CALCAGNO, Lara</creatorcontrib><title>Aberrant Expression of CD8 in B-Cell Non-Hodgkin Lymphoma: A Multicenter Study of 951 Bone Marrow Samples With Lymphomatous Infiltration</title><title>American journal of clinical pathology</title><addtitle>Am J Clin Pathol</addtitle><description>T-cell antigen expression can be observed in B-cell non-Hodgkin lymphoma (B-NHL). Although CD5 is expressed in B-cell chronic lymphocytic leukemia (B-CLL) and mantle cell lymphoma, the presence of other T-cell antigens is less common. This article reports a retrospective multicenter analysis in which flow cytometry was used to evaluate aberrant CD8 expression on the pathologic B cells of 951 bone marrow samples from patients with various types of B-NHL. In a total of 18 patients, CD8 was coexpressed: 10 had B-CLL; 1, small lymphocytic lymphoma (SLL); 1, marginal zone lymphoma; 1, lymphoplasmacytic lymphoma; 2, diffuse large B-cell lymphoma; and 3, follicular lymphoma. There was a 1.89% overall frequency of CD8 coexpression in which B-CLL/SLL had a higher frequency (3.03%) than did the other B-cell neoplasms (1.18%). Most cases were characterized by a favorable outcome.</description><subject>Antigens, CD19 - biosynthesis</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Bone Marrow - metabolism</subject><subject>Bone Marrow - pathology</subject><subject>CD5 Antigens - biosynthesis</subject><subject>CD8 Antigens - biosynthesis</subject><subject>Flow Cytometry</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphoma, B-Cell - metabolism</subject><subject>Lymphoma, B-Cell - pathology</subject><subject>Medical sciences</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. 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Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphoma, B-Cell - metabolism</topic><topic>Lymphoma, B-Cell - pathology</topic><topic>Medical sciences</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Antigens, CD19 - biosynthesis Biological and medical sciences Biomarkers, Tumor - analysis Bone Marrow - metabolism Bone Marrow - pathology CD5 Antigens - biosynthesis CD8 Antigens - biosynthesis Flow Cytometry Hematologic and hematopoietic diseases Humans Investigative techniques, diagnostic techniques (general aspects) Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, B-Cell - metabolism Lymphoma, B-Cell - pathology Medical sciences Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Retrospective Studies |
| title | Aberrant Expression of CD8 in B-Cell Non-Hodgkin Lymphoma: A Multicenter Study of 951 Bone Marrow Samples With Lymphomatous Infiltration |
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