Abundant ribonucleotide incorporation into DNA by yeast replicative polymerases

Measurements of nucleoside triphosphate levels in Saccharomyces cerevisiae reveal that the four rNTPs are in 36- to 190-fold molar excess over their corresponding dNTPs. During DNA synthesis in vitro using the physiological nucleoside triphosphate concentrations, yeast DNA polymerase ε, which is imp...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-03, Vol.107 (11), p.4949-4954
Hauptverfasser:	Nick McElhinny, Stephanie A, Watts, Brian E, Kumar, Dinesh, Watt, Danielle L, Lundström, Else-Britt, Burgers, Peter M.J, Johansson, Erik, Chabes, Andrei, Kunkel, Thomas A
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biological Sciences Deoxyribonucleic acid Deoxyribonucleotides - metabolism DNA DNA polymerase DNA Replication DNA, Fungal - metabolism DNA-Directed DNA Polymerase - metabolism Gels Genomes Genomics Kinetics MEDICIN MEDICINE Nucleic acids Nucleotides Protein folding Protein synthesis Ribonucleotides Ribonucleotides - metabolism RNA Saccharomyces cerevisiae Saccharomyces cerevisiae - enzymology Substrate Specificity Templates, Genetic Yeast Yeasts
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