TNF polymorphisms in psoriasis: Association of psoriatic arthritis with the promoter polymorphism TNF‐857 independent of the PSORS1 risk allele

Objective Single‐nucleotide polymorphisms (SNPs) of the tumor necrosis factor gene TNF at positions −238 and −308 have been associated with psoriasis vulgaris and psoriatic arthritis (PsA). The strong linkage disequilibrium (LD) at chromosome region 6p21, a region known to harbor risk factors for ps...

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Veröffentlicht in:	Arthritis and rheumatism 2007-06, Vol.56 (6), p.2056-2064
Hauptverfasser:	Reich, Kristian, Hüffmeier, Ulrike, König, Inke R., Lascorz, Jesús, Lohmann, Jörg, Wendler, Jörg, Traupe, Heiko, Mössner, Rotraut, Reis, André, Burkhardt, Harald
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alleles Arthritis, Psoriatic - genetics Biological and medical sciences Case-Control Studies Dermatology Diseases of the osteoarticular system Genetic Predisposition to Disease Haplotypes Humans Inflammatory joint diseases Linkage Disequilibrium - genetics Medical sciences Middle Aged Polymorphism, Single Nucleotide - genetics Proteins - genetics Psoriasis. Parapsoriasis. Lichen Risk Factors Tumor Necrosis Factor-alpha - genetics
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